50 results about "Piperazine hydrochloride" patented technology

The invention discloses a preparation method for urapidil, and relates to an inverse phase transfer catalysis method for preparing urapidil, and belongs to the technical field of organic synthesis. The method comprises the following steps that: water is adopted as a solvent; an inorganic alkaline substance is adopted as an acid binding agent; 6-(3-chloropropyl)-1,3-dimethyluracil (I) reacts with 1-(2-methoxyphenyl)piperazine hydrochloride (II) in the presence of an inverse phase transfer catalyst to generate 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]-propyl]-amino]-1,3-dimethyl-uracil (III, urapidil). With the method, the high-selectivity and high-yield preparation of the urapidil can be realized; the prepared urapidil has high purity, wherein the purity of the urapidil is more than 99.5%;the conversion rate is high; the yield can reach 80%; the reaction conditions are mild; the selectivity is good; the post-treatment is simple; the method is environmental-friendly, and is suitable for the industrial production.

The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypertension, cerebral disorders, chronic pain, acromegaly, hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.

The invention includes the synthesis of aripiprazole from BBQ and DCP, and comprises mixing 7-(4-bromobutoxy)-3,4-dihydrocarbostyril (BBQ) and 1-(2,3-dichlorophenyl)piperazine hydrochloride (DCP) in the presence of at least one base and at least one organic solvent to form a reaction mixture; heating the reaction mixture for a sufficient amount of time to effect the reaction; and isolating aripiprazole. The invention also includes the use of phase transfer catalysts in synthesizing aripiprazole from BBQ and DCP.

1-chloroformyl-4-methylpiperazine hydrochloride is an important organic synthesis intermediate, and the present invention uses bis(trichloromethyl)carbonate and N-methylpiperazine as raw materials to react in an organic solvent have to. The chemical synthesis method eliminates safety hazards and sources of three wastes from the source of the process, and is a 1-chloroformyl-4-methylpiperazine with easy-to-obtain raw materials, safe and reliable production, high reaction yield, low production cost, and basically no three wastes Synthesis method of hydrochloride.

The invention discloses a detection method and application of brexpiprazole related substances. According to the detection method of the brexpiprazole related substances, the brexpiprazole related substances such as an intermediate 7-hydroxy-1H-quinoline-2-ketone (intermediate 1), 7-(4-chlorobutoxy)-1H-quinoline-2-ketone (intermediate 2) and 1-(benzo [b] thiophene-4-yl) piperazine hydrochloride (intermediate 3) and an impurity 1-bromo-4-chlorobutane can be detected at one time; the separation degree is good, the detection time is short, and the elution procedure is simple. The method is applied to preparation of brexpiprazole, the quality of each intermediate can be controlled, and the product quality can be more effectively controlled.

A fluorescence assay method for flavoxate hydrochloride comprises the following steps: preparing a sample solution of flavoxate hydrochloride tablets, drawing a series of concentration FX standard curves and measuring the sample concentration. When measuring the sample concentration, heat the diluted sample solution in a boiling water bath under a strong alkaline environment, and after cooling, use a fluorescence spectrophotometer to scan the fluorescence spectrum, measure the fluorescence intensity at λex / λem=302 / 410 nm, and calculate the sample solution Concentration of FX in . The invention uses a fluorescence measurement method to measure the FX content in the flavoxate hydrochloride tablets, has high sensitivity, fast analysis speed, simple and convenient test conditions, is environmentally friendly, and greatly reduces the amount of required samples.