50 results about "Methylamine hydrochloride" patented technology

Production of N-methyl-3,5-bistriflumethylaniline is carried out by oximation reacting 3,5-bistriflutoluyl aldehyde with methylamine hydrochloride, catalyzing and reducing the products. It yields more and is cheap.

The invention discloses a preparation method of galanthamine key intermediate -N-methyl(4-leptodactyline)-2-bromo-5-hydroxyl-4-methoxybenzylamine. The preparation method comprises the following steps: by taking 2-bromo-5-benzyloxy-4-methoxybenzaldehyde, benzyloxyphenyl ethanol and methylamine hydrochloride as raw materials, condensing, degrading and performing debenylation reaction to prepare N-methyl(4-leptodactyline)-2-bromo-5-hydroxyl-4-methoxybenzylamine. Cheap and easily available raw materials are adopted in the method, so that the production cost can be effectively controlled, the operation is simple, and the reaction conditions are mild. The intermediate is used for industrial synthesis of galanthamine, and the problem that the yield from the industrial production of galanthamine is low can be effectively solved.

The invention discloses a method for synthesizing 1-nitroso-3,5,7-trinitro-1,3,5,7-tetraazacyclooctane. Its steps are: first at low temperature 3,7-dinitro-1,3,5,7-tetraazabicyclo [3.3.1] nonane in methylamine hydrochloride and mass fraction of 96% fume Carry out nitrolysis reaction and nitrolysis reaction in nitric acid system; slowly add water dropwise, filter, wash with water, and dry to obtain 1‑nitroso‑3,5,7‑trinitroso‑1,3,5,7‑tetraaza Cyclooctane. The method avoids the use of ammonium nitrate, the obtained product has high purity, and the yield reaches 78.5%; it also avoids the use of sodium nitrite or dinitrogen tetroxide, etc., which simplifies the production process, reduces production costs, and reduces environmental pollution; improves production safety .

The invention concretely relates to a vonoprazan fumarate preparation method, and belongs to the field of medicines and chemical engineering. The method comprises the following steps: 1, carrying out condensation on 2-fluoroacetophenone used as an initial raw material and allylamine to obtain a compound IV; 2, carrying out a ring closing reaction on the compound IV under the catalysis of a copper catalyst in the presence of a ligand in order to obtain a compound V; 3, carrying out a sulfoamidation reaction on the compound V and pyridine-3-sulfonyl chloride to generate a compound VII; 4, carrying out a bromination reaction on the compound VII by using N-bromosuccimide in order to generate a compound VIII; 5, carrying out an amination reaction on the compound VIII and methylamine hydrochloride under the action of a catalyst and an alkali in order to obtain vonoprazan alkali; and 6, carrying out salt formation on the vonoprazan alkali and fumaric acid in order to obtain vonoprazan fumarate. The preparation method has the advantages of simplicity in operation, mild reaction conditions, high yield and high purity of the product, and easiness in industrial production.