12 results about "Tryptophan methyl ester" patented technology

The present invention provides a method for preparing a premixed feed from a tryptophan fermentation broth, belonging to the technical field of animal feeds. The preparation method includes preparing modified corncobs, preparing methyl tryptophan, transesterification reaction, and granulation. The method for the transesterification reaction is to add methyl tryptophan, modified corncobs, and catalyst K 2 CO 3 into a reactor, mix them evenly, heat up to 110-140 °C, and then carry out a constant-temperature reaction for 7-9 h. During the reaction process, the reaction by-product methanol is distilled out simultaneously. After the reaction is completed, glacial acetic acid is added to neutralize catalyst K 2 CO 3 , and then deionized water is added. After standing and separating layers, the upper-layer product is washed clean and dried to obtain a modified corncob / tryptophan complex. The premixed feed of the present invention has good stability, no tryptophan crystals precipitate within 30 days, and has a high tryptophan content of 19.5-21%.

The invention discloses a preparation method and application of a compound with a cold sensing regulation effect, which comprises the following steps: dissolving tryptophan in methanol, adding concentrated sulfuric acid, esterifying the acid to protect carboxyl so as to obtain tryptophan methyl ester, dissolving the obtained tryptophan methyl ester and aromatic carboxylic acid substances in N, N-dimethylformamide, and reacting to obtain the compound with the cold sensing regulation effect. The method comprises the following steps: catalyzing 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethylurea hexafluorophosphate and N, N-diisopropylethylamine, dissolving a catalyzed product in ethanol (98%), adding into a NaOH solution, stirring, carrying out rotary evaporation treatment, slowly dropwise adding a 0.5 mol / L hydrochloric acid solution, adjusting the pH value of a reaction system to 3-4, and finally obtaining the tryptophan derivative compound with the yield of 70%. The invention provides a potential medicine for improving the working ability and cold injury in the cold environment for people living and working in the cold environment, and is developed into a medicine for effectively improving neuropathic pain diseases in the cold environment.

The invention belongs to the technical field of medicines, and particularly relates to a beta-elemene tryptophan methyl ester derivative and application thereof in preparation of antitumor drugs. According to the beta-elemene tryptophan methyl ester derivative with the structure as shown in the formula (I), on the basis of maintaining a beta-elemene structural framework, a tryptophan methyl ester group is introduced to the 13th site of beta-elemene, and unsubstituted C3-7 heterocycloalkyl, substituted C3-7 heterocycloalkyl, unsubstituted C5-11 hetero-spirocycloalkyl or substituted C5-11 hetero-spirocycloalkyl is introduced to the 14th site of beta-elemene, so that the beta-elemene tryptophan methyl ester derivative with the structure as shown in the formula (I) is obtained. The water solubility and the pharmacokinetic property of the compound are effectively improved. Experimental results show that the anti-tumor activity of the beta-elemene tryptophan methyl ester derivative with the structure as shown in the formula (I) provided by the invention is obviously enhanced compared with that of beta-elemene. Formula (I).

The invention discloses a preparation method and application of starwort alkali A. Belongs to the technical field of organic synthesis. The invention provides a synthesis method of a compound starwort alkali A. The method comprises the following steps: carrying out a cyclization condensation reaction on L-tryptophan methyl ester hydrochloride and methylglyoxal under the catalysis of acid by adopting a Pictet-Spengula reaction, and carrying out an ammonolysis reaction to obtain a target compound. The method has the following advantages: the reaction steps are simple, complicated separation and purification are not needed, and the operation convenience is improved; the reaction selectivity is relatively high, a target compound with relatively high purity can be obtained, and the synthesis efficiency is improved; reaction reagents are low in price, so that the synthesis cost is reduced. The anti-anxiety activity of the stelline A is researched for the first time, and the action mechanism of the stelline A is clarified.

The invention provides a method for preparing a premixed feed from tryptophan fermentation broth, and belongs to the technical field of animal feeds, the preparation method comprises the following steps: preparing modified corncob, preparing tryptophan methyl ester, carrying out transesterification and granulating, and the transesterification method comprises the following steps: adding the tryptophan methyl ester, the modified corncob and a catalyst K2CO3 into a reactor, uniformly mixing, adding the modified corncob and the catalyst K2CO3 into the reactor, and granulating to obtain the premixed feed. The preparation method comprises the following steps: heating to 110-140 DEG C, then carrying out constant-temperature reaction for 7-9 hours, simultaneously steaming out a reaction byproduct methanol in the reaction process, after the reaction is finished, adding glacial acetic acid and a neutralization catalyst K2CO3, then adding deionized water, standing for layering, and then cleaning and drying an upper-layer product to obtain a modified corncob / tryptophan compound; the premix feed disclosed by the invention is good in stability, colorless tryptophan crystals are separated out within 30 days, and the content of tryptophan is high and is 19.5-21%.

The invention discloses a preparation method of a tryptophan derivative, and relates to the field of pharmaceutical chemicals. Comprising the following steps: taking Boc-L-tryptophan methyl ester as a raw material, and introducing methyl through methyl iodide to generate Boc-L-tryptophan (1-Me) methyl ester; the method comprises the following steps: carrying out methyl ester removal on Boc-L-tryptophan (1-Me) methyl ester under an alkaline condition to generate Boc-L-tryptophan (1-Me); boc of Boc-L-tryptophan (1-Me) is removed under the acidic condition, and L-tryptophan (1-Me) is generated; adding a protecting group on the amino group of the L-tryptophan (1-Me) to generate amino-protected L-tryptophan (1-Me); according to the route mode, the side reaction that tryptophan main chain amino or carboxyl is protected is avoided, the yield is high, the reaction temperature is relatively simple, the production cost is relatively low, the refining process is simplified, the yield is also improved, and the production benefit is relatively high.

The present invention provides a fusidic acid derivative, a preparation method and an application thereof. By connecting 1-carboxy-2-(β-indolyl)ethylamine (or L-tryptophan methyl ester fragment) to the carboxyl group at the C-21 position of fusidic acid, the introduction of 1-carboxy-2-(β-indolyl)ethylamine can promote the interaction of the fusidic acid derivative with the receptor, thereby improving the anti-tumor activity of the fusidic acid derivative, and it has good selectivity for normal cells. Finally, a fusidic acid derivative with a specific structure, excellent anti-tumor activity and good selectivity for normal cells is obtained. The present invention performs structural modification and optimization on the basis of the natural product fusidic acid, improves its physicochemical properties, enhances its pharmacological activity and improves its drug-likeness. The preparation method of the fusidic acid derivative provided by the present invention has the advantages of rich raw material sources, mild reaction conditions, simple operation in the reaction process, and cheap and easily available reagents.

The application relates to the technical field of organic synthesis, and discloses a method for preparing tadalafil or epi-tadalafil, which comprises the following steps: reacting N-(1,3-benzodioxol-5-methyl)-D-tryptophan methyl ester with Fomc-Ala-Cl to prepare compound IIa or compound IIb; and performing a deprotection / aminolysis reaction and a cyclization reaction on the compound IIa or the compound IIb in the presence of methylamine to prepare tadalafil or epi-tadalafil. Through the selection of a specific (Fomc-Ala-Cl) acylation reagent, the purity and / or yield of the compound IIa or the compound IIb are improved, so that the yield and / or purity of the tadalafil and / or epi-tadalafil are improved.

The invention relates to the technical field of perovskite light-emitting device production, in particular to an efficient all-inorganic tin-based near-infrared perovskite light-emitting diode and a preparation method thereof. Comprising the following steps: mixing a poly (4-sodium p-styrenesulfonate) solution with PEDOT: PSS to obtain a modified hole transport layer solution; spin-coating the modified hole transport layer solution on an ITO substrate, and heating and annealing to form a modified hole transport layer; the preparation method comprises the following steps: dissolving CsI, SnI2, L-tryptophan methyl ester hydrochloride and RbSCN in a DMSO solvent, then adding tin powder, and stirring to obtain a perovskite precursor solution; spin-coating the modified hole transport layer with a perovskite precursor solution, and forming a perovskite thin film layer after heating and annealing; and sequentially evaporating TPBi, LiF and Al on the perovskite thin film layer under a vacuum condition to obtain the all-inorganic tin-based perovskite light-emitting diode. According to the invention, the dependence of the tin-based perovskite light-emitting diode preparation process on a tin compensation agent is overcome, and high-efficiency near-infrared light emitting is realized.

The invention relates to a tetrahydro-beta-carboline derivative with optical activity and a preparation method thereof, and the preparation method comprises the following steps: S1, mixing D-tryptophan methyl ester hydrochloride with an organic solvent to obtain a mixed system; s2, adding an aldehyde compound into the mixed system to obtain a reaction system; s3, the reaction system is heated to reflux, a reaction is carried out under the reflux condition, the tetrahydro-beta-carboline derivative is obtained, and the tetrahydro-beta-carboline derivative is of a cis-configuration or a trans-configuration. According to the method, D-tryptophan methyl ester hydrochloride and an aldehyde compound are subjected to a reaction under the reflux condition, the tetrahydro-beta-carboline derivative with optical activity is obtained, the preparation method is simple, no catalyst needs to be used, the reaction condition is mild, the obtained reaction product is of a single cis-configuration or trans-configuration, and the method is suitable for industrial production. Column chromatography separation is not needed, and post-treatment is simple.

This invention discloses a method for preparing siliceous alkaloid A and its application. It belongs to the field of organic synthesis technology. This invention provides a method for synthesizing the compound siliceous alkaloid A, which employs a Pictet-Spengular reaction, causing L-tryptophan methyl ester hydrochloride to undergo a cyclization condensation reaction with methylglyoxal under acid catalysis, followed by ammonolysis to obtain the target compound. This method has the following advantages: simple reaction steps, eliminating the need for complex separation and purification, improving operational convenience; high reaction selectivity, yielding a high-purity target compound, improving synthesis efficiency; and low-cost reagents, reducing synthesis costs. This invention is the first to study the anti-anxiety activity of siliceous alkaloid A and elucidate its mechanism of action.

The invention discloses a novel nanofiltration concentration separation flux stabilizer and a preparation method thereof, and relates to the field of water treatment. The novel nanofiltration concentration separation flux stabilizer is prepared using a metal compound, an organic acid, an inorganic oxidant, and an organic oxidant, and has a good calcium ion removal effect, so that the nanofiltration membrane can maintain good flux stability. In addition, sodium alginate modified with D-tryptophan methyl ester hydrochloride is added during the preparation process, so that the prepared novel nanofiltration concentration separation flux stabilizer has a better calcium ion removal effect and COD removal effect, and the nanofiltration membrane has a better flux stability.