30 results about "Secondary amenorrhea" patented technology

The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypertension, cerebral disorders, chronic pain, acromegaly, hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.

The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of these compounds are related to contraception, the treatment and / or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minication of side effects of cyclid menstrual bleeding. Additional uses of the invention include stimulation of food intake.

The invention discloses a traditional Chinese medicine composition for treating secondary amenorrhea, comprising angelica, rehmannia glutinosa, rehmannia glutinosa, white peony root, American ginseng, antler, dodder seed, chrysanthemum seed, amomum seed, medlar fruit, cornus officinalis, cypress seed, atractylodes macrocephala, Cyperus cyperi . The raw materials of the present invention are coordinated together to maximize the efficacy of the drug, to nourish the liver and kidney, to nourish blood and replenish essence, to soothe the liver and stimulate the menstrual flow, to regulate yin and yang, and to treat both symptoms and root causes.

The invention discloses a new medicine for dredging water and regulating menstruation. Chinese medicine, raw and cooked rehmannia root, safflower, Chinese yam, angelica, and leeches are used as raw materials. During preparation, the above-mentioned traditional Chinese medicine is soaked in water, decocted to obtain juice, after distillation, reflux, filtration, and clarification, the supernatant is autoclaved and bottled. into oral liquid. The medicine of the invention has the advantages of good curative effect and high cure rate when treating women with less menstrual flow and secondary amenorrhea.

The invention provides a preparation route for a vilazodone hydrochloride crystal form XI: vilazodone hydrochloride with the crystal form XI is obtained by a series of operations such as dilution, pHregulation, crystallization and drying, and the problem that the crystal form XI cannot be obtained by the route of the prior patent. The drug is used for treating or preventing depression, anxiety, bipolar disorder, mania, dementia, mental disorders associated with psychoactive substances, sexual dysfunction, eating disorder, obesity, fibromyalgia, sleep disorder, psychosis-like mental disorders,cerebral infarction, tension, side effects in hypertension treatment, brain diseases, chronic pain, acromegaly, hypogonadism, secondary amenorrhea and premenstrual syndrome.

The invention relates to a modulator of nonsteroidal progesterone receptor with a structure of the general formula I or an acceptable salt on pharmacy and a preparation method thereof. The invention also relates to drug combination including compounds of the general formula I or an acceptable salt on pharmacy thereof and the antagonist activity of progesterone receptor which is provided by the compounds of the general formula I or the acceptable salt on pharmacy thereof; therefore, the invention can be used for preparing nonsteroidal drugs to prevent and (or) or treat symptoms or diseases such as secondary amenorrhea, functional bleeding disorder, uterine fibroids, endometriosis, polycystic ovary syndrome, breast cancer, contraceptive, induced labor, and termination of pregnancy, etc.

The invention provides a progesterone ethosome. Progesterone is encapsulated in an ethosome. The progesterone ethosome comprises the following components in percentage by weight: 0.1 to 1 percent of progesterone, 1 to 8 percent of lipid materials, 0 to 0.6 percent of cholesterol, 20 to 50 percent of short-chain alcohols, 0 to 3 percent of nonionic surfactant and the balance of water. The preparation method comprises the following steps of: mixing and dissolving the progesterone, the lipid materials, the cholesterol and the short-chain alcohols to prepare an alcohol phase; with stirring, adding the alcohol phase into a nonionic surfactant-containing aqueous phase to prepare primary emulsion under the condition of stirring; homogenizing the primary emulsion under a high pressure to obtain asuspension; stirring the ethosome suspension for 15 to 30 minutes to perform emulsification for the second time; and curing the suspension by cooling the suspension at 0 to 4 DEG C to obtain the progesterone ethosome. Because the high-pressure homogenization method is adopted to prepare the progesterone ethosome, the progesterone ethosome is low in stimulation to skin and high in transdermal delivery ability, and metal ion pollution which is easy to cause by the probe ultrasound method of the traditional homogenization method is avoided. Therefore, the progesterone ethosome is suitable for industrial production. The progesterone ethosome can be prepared into a transdermal drug delivery system, a mucosal drug delivery system, and topical dosage forms, such as a paster, a gel and the like. The progesterone ethosome is mainly applied to hormone replacement therapy, secondary amenorrhea, functional aplastic bleeding, premenstrual syndrome and the like clinically.

The invention discloses a traditional Chinese medicine for treating female infertility, which is prepared from the following raw materials in the weight ratio: 20-25 parts of rehmannia glutinosa, 10-15 parts of Codonopsis pilosula, 9-12 parts of angelica, and 5-7 parts of chuanxiong , 8-10 parts of Radix Paeoniae Alba, 8-10 parts of Morinda officinalis, 12-16 parts of Cyperus cyperi, 5-7 parts of fennel, 8-10 parts of psoralen, 3-5 parts of licorice, 8-10 parts of Wang Buliuxing 8-10 parts of medlar. The present invention selects 12 traditional Chinese medicines, which are scientifically compatible, have comprehensive medicinal effects, and have remarkable curative effects. The synergistic action of each raw material plays the role of enriching blood, promoting blood circulation and removing stasis, promoting qi circulation and unblocking stagnation, and is effective for secondary amenorrhea and poor ovulation. At the same time, it can nourish the kidney and yang, nourish the spleen and Qi, warm the kidney and nourish the liver, regulate menstruation and help pregnancy, and is effective for infertility due to kidney deficiency. The medicine of the invention treats both the symptoms and root causes, has good therapeutic effect, low cost and no toxic and side effects.

The invention discloses a traditional Chinese medicine composition for treating secondary amenorrhea. The traditional Chinese medicine composition is prepared from radix angelicae sinensis, radix rehmanniae, radix rehmanniae preparata, radix paeoniae alba, American ginseng, cornu cervi pantotrichum, semen cuscutae, flatstem milkvetch seeds, fructus amomi, fructus lycii, fructus corni, motherwort fruits, rhizoma atractylodis macrocephalae and rhizoma cyperi. The raw material medicines are mutually coordinated together, so that the medicine effect can be exerted to the greatest extent, the effects of tonifying liver and kidney, nourishing blood and replenishing essence, soothing liver and stimulating menstrual flow, regulating yin and yang and treating both symptoms and root causes are achieved, the use is convenient, and the electuary can be taken.