30 results about "Secondary amenorrhea" patented technology

The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypertension, cerebral disorders, chronic pain, acromegaly, hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.

The invention provides a progesterone ethosome. Progesterone is encapsulated in an ethosome. The progesterone ethosome comprises the following components in percentage by weight: 0.1 to 1 percent of progesterone, 1 to 8 percent of lipid materials, 0 to 0.6 percent of cholesterol, 20 to 50 percent of short-chain alcohols, 0 to 3 percent of nonionic surfactant and the balance of water. The preparation method comprises the following steps of: mixing and dissolving the progesterone, the lipid materials, the cholesterol and the short-chain alcohols to prepare an alcohol phase; with stirring, adding the alcohol phase into a nonionic surfactant-containing aqueous phase to prepare primary emulsion under the condition of stirring; homogenizing the primary emulsion under a high pressure to obtain asuspension; stirring the ethosome suspension for 15 to 30 minutes to perform emulsification for the second time; and curing the suspension by cooling the suspension at 0 to 4 DEG C to obtain the progesterone ethosome. Because the high-pressure homogenization method is adopted to prepare the progesterone ethosome, the progesterone ethosome is low in stimulation to skin and high in transdermal delivery ability, and metal ion pollution which is easy to cause by the probe ultrasound method of the traditional homogenization method is avoided. Therefore, the progesterone ethosome is suitable for industrial production. The progesterone ethosome can be prepared into a transdermal drug delivery system, a mucosal drug delivery system, and topical dosage forms, such as a paster, a gel and the like. The progesterone ethosome is mainly applied to hormone replacement therapy, secondary amenorrhea, functional aplastic bleeding, premenstrual syndrome and the like clinically.

The invention provides a Chinese medicine for treating secondary amenorrhea. The Chinese medicine comprises the following components in part by weight: 12 to 18 parts of fluorite, 9 to 15 parts of purple salvia miltiorrhiza, 12 to 18 parts of Chinese sage herb, 3 to 7 parts of amber powder, 25 to 35 parts of Huai wheat, 8 to 12 parts of albizia julibrissin, 9 to 15 parts of platycladi seed, 9 to 15 parts of curcuma wenyujin, and 9 to 15 parts of raw tamariskoid spikemoss herb. Compared with the prior art, the Chinese medicine for treating secondary amenorrhea can treat secondary amenorrhea by differentiation of symptoms aiming at the internal pathogenic factors of secondary amenorrhea, has quick response, is low in cost, does not have toxic or side effects and can achieve effects of addressing both the symptoms and root causes.

The invention relates to a modulator of nonsteroidal progesterone receptor with a structure of the general formula I or an acceptable salt on pharmacy and a preparation method thereof. The invention also relates to drug combination including compounds of the general formula I or an acceptable salt on pharmacy thereof and the antagonist activity of progesterone receptor which is provided by the compounds of the general formula I or the acceptable salt on pharmacy thereof; therefore, the invention can be used for preparing nonsteroidal drugs to prevent and (or) or treat symptoms or diseases such as secondary amenorrhea, functional bleeding disorder, uterine fibroids, endometriosis, polycystic ovary syndrome, breast cancer, contraceptive, induced labor, and termination of pregnancy, etc.

The invention discloses a traditional Chinese medicine for treating infertility, which is prepared from the following raw materials in parts by weight: 20-25 parts of prepared rehmannia root, 10-15 parts of root of hairy asiabell, 9-12 parts of Angelica sinensis, 5-7 parts of Rhizoma Chuanxiong, 8-10 parts of white paeony root, 8-10 parts of Morinda officinalis, 12-16 parts of rhizoma cyperi, 5-7 parts of fennel, 8-10 parts of fructus psoraleae, 3-5 parts of licorice root, 8-10 parts of seed of cowherb and 8-10 parts of fruit of Chinese wolfberry. According to the invention, 12 kinds of traditional Chinese medicines are selected and scientifically matched, pharmaceutical effects are synthesized and curative effect is remarkable. All medicinal raw materials cooperates with each other to enrich blood, activate blood circulation to dissipate stasis and promote the circulation of qi and eliminate sluggish, is effective to secondary amenorrhea and poor ovulation. Meanwhile, the traditional Chinese medicine can reinforce kidneys to strengthen yang, tonify spleen, benefit vital energy, warm kidneys and nurse liver, can regulate menstruation and facilitate fertilization, and is effective to the patients with infertility caused by deficiency of the kidney. The medicine provided by the invention treats both symptoms and root causes, the treatment effect is good, the cost is low and toxic and side effects are avoided.

The invention discloses a traditional Chinese medicine for treatment of female sterility infertility. The traditional Chinese medicine is prepared from the following raw materials by weight: 20-25 parts of radix rehmanniae preparata, 10-15 parts of codonopsis pilosula, 9-12 parts of Chinese angelica, 5-7 parts of Ligusticum wallichii, 8-10 parts of white paeony root, 8-10 parts of morinda officinalis, 12-16 parts of cyperus rotundus, 8-10 parts of Psoralea corylifolia, 3-5 parts of licorice, and 8-10 parts of Chinese wolfberry. The traditional Chinese medicine provided by the invention is directed at treatment of female sterility infertility caused by ovulatory dysfunction, menstrual disorder, dual depletion of qi and blood and other problems, and treatment is based on menstruation regulation and ovulation induction. According to the invention, 10 drugs are selected for scientific compatibility, and the efficacy is integrated to reach a significant curative effect. All the bulk drugs cooperate to achieve the effects of replenishing blood, activating blood circulation to dissipate stasis, promoting flow of qi and removing stagnancy, and are effective to secondary amenorrhea and unsmooth ovulation. At the same time, the traditional Chinese medicine can reinforce kidney and strengthen yang, tonify spleen and benefit qi, warm the kidney and nourish liver, regulate menstruation and assist pregnancy, and is effective for sterility due to kidney deficiency. The drug provided by the invention has the advantages of treatment of both causes and symptoms, good treatment effect, low cost, and no toxic or side effect, and has an effective rate up to 95% or more.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating infertility and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-20 parts of wine-fried radix paeoniae alba, 5-20 parts of radix paeoniae rubra, 5-20 parts of rhizoma corydalis, 5-20 parts of poria, 10-30 parts of herba cistanche, 10-30 parts of fructus corni, 10-30 parts of herba leonuri, 5-20 parts of rhizoma chuanxiong, 5-20 parts of vinegar-porcessed rhizoma cyperi, 5-20 parts of rehmanniae vaporata, 5-20 parts of radix angelicae sinensis, 5-20 parts of radix salviae miltiorrhizae, 5-20 parts of herba epimedii, 10-30 parts of stir-baked rhizoma dioscoreae, 5-20 parts of rhizoma curculiginis and 5-20 parts of vinegar-calcined actinolite. The traditional Chinese medicine composition is less in taste number, small in quantity and quick in effect taking, and can immediately recover development of endometrium, regulate irregular menstruation to be normal, enable a fallopian tube to be smooth, promote ovarian ovulation and quicken early pregnancy. The traditional Chinese medicine composition can regulate menstruation and enrich blood and regulate and treat infrequent menstruation, inaccurate menstrual period and secondary amenorrhea, solves the problems of poor luteal function, long-time infertility, anovulation and the like, can promote ovary smoothness and quick development of the fallopian tube.

The invention discloses a traditional Chinese medicine preparation for treating amenorrhea. The traditional Chinese medicine preparation comprises the following raw medicinal materials in parts by weight: 30 parts of Chinese angelica, 30 parts of beautiful sweetgum fruits, 30 parts of leonurus, 15 parts of hiraute shiny bugleweed herbs, 15 parts of combined spicebush roots, 15 parts of nutgrass galingale rhizome, 15 parts of oriental waterplantain rhizome, 15 parts of white paeony roots, 15 parts of wenchow turmeric root tuber 15 parts of corydalis tubers, 20 parts of Szechuan lovage rhizomes and 20 parts of red flower. The preparation can be prepared into pills, capsule preparations, oral liquid preparations, tablets and powders by using the traditional preparation process or the modern preparation process. The combination of the selected medicinal materials has the efficacies of invigorating circulation of blood, eliminating stasis, clearing away heat and toxic materials, soothing the liver and regulating the flow of vital energy. The traditional Chinese medicine preparation improves the immune functions of organisms through oral administration, and has good treatment effect on primary amenorrhea and secondary amenorrhea. Clinic applications show that the traditional Chinese medicine preparation has the advantages of quick action, obvious treatment effect, good tolerance, low cost and no toxic or side effect.

The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of these compounds are related to contraception, the treatment and / or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minication of side effects of cyclid menstrual bleeding. Additional uses of the invention include stimulation of food intake.

The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of these compounds are related to contraception, the treatment and / or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minication of side effects of cyclid menstrual bleeding. Additional uses of the invention include stimulation of food intake.

The invention discloses traditional Chinese medicine for treating female infertility. The traditional Chinese medicine is prepared from, by weight, 20-25 parts of prepared rehmannia roots, 10-15 parts of codonopsis pilosula, 9-12 parts of angelica sinensis, 5-7 parts of ligusticum wallichii, 8-10 parts of radix paeoniae alba, 8-10 parts of morinda officinalis, 12-16 parts of cyperus rotundus, 8-10 parts of fructus psoraleae, 3-5 parts of raw liquorice and 8-10 parts of fructus lycii. The medicine has the effects of replenishing blood, activating blood circulation to dissipate stasis and prompting circulation of qi to remove stagnation and is effective for secondary amenorrhea and unsmooth ovulation. The traditional Chinese medicine can reinforce the kidney to strengthen yang, tonify the spleen to benefit qi, warm the kidney to nourish the liver and regulate menstruation to promote gestation, and is effective for kidney-deficiency sterile people. The medicine treats both causes and symptoms, and is good in treatment effect, low in cost and free of toxic and side effects.

The invention discloses a radix ginseng and cortex cinnamomi amenorrhea plaster which comprises the following raw materials in parts by weight: 23-49 parts of alcohol processed radix angelica sinensis, 13-28 parts of cortex cinnamomi, 3-9 parts of fried licorice roots, 6-19 parts of radix ginseng, 8-21 parts of motherwort, 7-14 parts of fennel, 5-18 parts of asarum, 3-9 parts of radix paeoniae rubra, 2-17 parts of rhizoma atractylodis, 3-20 parts of dried tangerine or orange peel, 5-30 parts of medicinal cyathula roots, 5-21 parts of fructus crataegi, 4-20 parts of copperas, 1-23 parts of mirabilite, 5-30 parts of radix clematidis, 3-29 parts of almonds, 5-30 parts of aluminite, 2-27 parts of radix sophorae flavescentis, 2-26 parts of fructus cnidii, 1 parts of Vaseline, 1 part of laurocapram, 1 part of glycerinum, 1 part of paraffin and 1 part of wool fat. The radix ginseng and cortex cinnamomi amenorrhea plaster is capable of treating female irregular menstruation such as scanty menstruation, delayed menstruation, premature menstruation, irregular menstruation and dysmenorrheal, and is capable of treating primary and secondary amenorrhea of females.

The menstruation regulating medicine is prepared with diverse wormwood herb, burreed rhizome, cowherb seed, pinellia tuber, haw and other ten kinds of Chinese medicinal materials. During preparation, the said Chinese medicinal materials are soaked in water, decocted, distilled, refluxed, filtered and clarified to obtain supernatant, which is bottled as the oral medicine liquid. The medicine of the present invention is used in treating oligomenorrhea and secondary amenorrhea, and has high curative effect.

The invention provides a traditional Chinese medicine formula for treating amenorrhea. The traditional Chinese medicine formula is characterized by comprising, by weight, 20 g of purple quartz, 15 g of salvia miltiorrhiza, 15 g of salvia chinensis benth, 15 g ofamber, 30 g of wheat, 15 g of albizia flowers, 12 g of platycladi seeds, 12 g of curcuma aromatica and 12 g of selaginella tamariscina. The traditional Chinese medicine formula for treating amenorrhea activates blood and regulates menstruation, moistens dryness and clams the mind and is mainly used for treating secondary amenorrhea, menelipsis lasting for three months and longer, dry stool, inquietude of sleeping, thin tongue fur, dark red tongue, fine pulse and the like.

The invention discloses a traditional Chinese medicine composition for treating secondary amenorrhea, comprising angelica, rehmannia glutinosa, rehmannia glutinosa, white peony root, American ginseng, antler, dodder seed, chrysanthemum seed, amomum seed, medlar fruit, cornus officinalis, cypress seed, atractylodes macrocephala, Cyperus cyperi . The raw materials of the present invention are coordinated together to maximize the efficacy of the drug, to nourish the liver and kidney, to nourish blood and replenish essence, to soothe the liver and stimulate the menstrual flow, to regulate yin and yang, and to treat both symptoms and root causes.

The invention discloses a decoction for treating secondary amenorrhea after benzene poisoning and a preparation method of the decoction. The decoction comprises the following components in parts by mass: 1-3 parts of angelica sinensis, 1-3 parts of parched white peony roots, 1-3 parts of semen cuscutae, 1-3 parts of ligusticum wallichii, 1-3 parts of radix rehmanniae preparata, 1-3 parts of rhizoma curculiginis, 1-3 parts of wolfberry, 1-3 parts of herba epimedii, 1-3 parts of semen plantaginis, 1-3 parts of raspberries, 1-3 parts of radix achyranthis bidentatae and 1-3 parts of schisandra chinensis. The preparation method of the decoction comprises the following steps of selecting the first-grade angelica sinensis, parched white peony roots, semen cuscutae, ligusticum wallichii, radix rehmanniae preparata, rhizoma curculiginis, wolfberry, herba epimedii, semen plantaginis, raspberries, radix achyranthis bidentatae and schisandra chinensis, and respectively removing impurities and dust to obtain drugs for later use; and placing the drugs into a cloth bag and sealing the cloth bag, then, soaking the drugs in purified water for about half an hour, then, simultaneously placing the soaked drugs and a clarified liquid of the soaked drugs into a drug decocting machine according to the standard that medicine tissues are permeated, injecting cold boiled water 35mm more than the volumes of the drugs to decoct for the first time for 35 minutes, filtering the liquid medicine, then, injecting micro-warm boiled water again to decoct for the second time for 30 minutes, mixing and concentrating to form 1200ml of liquid traditional Chinese medicine with the concentration of 50%.

The invention discloses a traditional Chinese medicine composition for treating female infertility. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-18 parts of radix rehmanniae praeparata, 10-12 parts of codonopsis pilosula, 9-12 parts of angelica sinensis, 6-10 parts of ligusticum wallichii, 8-10 parts of white peony root, 10-12 parts of morinda officinalis, 10-15 parts of cyperus rotundus, 8-10 parts of fructus psoraleae, 5-8 parts of liquorice, 8-10 parts of wolfberries, 8-10 parts of cassia twig and 5-8 parts of cinnamon. The drug has the effects of enriching blood, activating blood circulation, removing stasis, promoting the qi circulation and dredging retention, and is effective for secondary amenorrhea and ovulation drainage, is capable of tonifying the kidneys, reinforcing yang, invigorating the spleen, replenishing qi, warming the kidneys, nourishing the liver, regulating mnstruation and helping pregnancy, and is effective for an infertility patient with kidney deficiency. The drug is capable of treating both cause and symptoms, and is good in treatment effect, low in cost and free of toxic or side effect, and the effective rate reaches over 95%.

The invention discloses a new medicine for dredging water and regulating menstruation. Chinese medicine, raw and cooked rehmannia root, safflower, Chinese yam, angelica, and leeches are used as raw materials. During preparation, the above-mentioned traditional Chinese medicine is soaked in water, decocted to obtain juice, after distillation, reflux, filtration, and clarification, the supernatant is autoclaved and bottled. into oral liquid. The medicine of the invention has the advantages of good curative effect and high cure rate when treating women with less menstrual flow and secondary amenorrhea.

The invention provides a preparation route for a vilazodone hydrochloride crystal form XI: vilazodone hydrochloride with the crystal form XI is obtained by a series of operations such as dilution, pHregulation, crystallization and drying, and the problem that the crystal form XI cannot be obtained by the route of the prior patent. The drug is used for treating or preventing depression, anxiety, bipolar disorder, mania, dementia, mental disorders associated with psychoactive substances, sexual dysfunction, eating disorder, obesity, fibromyalgia, sleep disorder, psychosis-like mental disorders,cerebral infarction, tension, side effects in hypertension treatment, brain diseases, chronic pain, acromegaly, hypogonadism, secondary amenorrhea and premenstrual syndrome.

The invention discloses an orally-taken drug for treating secondary amenorrhea and a preparation method thereof. The orally-taken drug is prepared from the following components in parts by mass: 1-3 parts of crude Chinese yam, 1-3 parts of roasted rhizoma atractylodis macrocephalae, 1-3 parts of raw chicken's gizzard-membrane, 1-3 parts of Chinese angelica and 1-3 parts of white peony roots. The preparation method for the drug comprises the following steps: selecting high-quality and clean primary crude Chinese yam, roasted rhizoma atractylodis macrocephalae raw chicken's gizzard-membrane, Chinese angelica and white peony roots in parts by mass, respectively picking out impurities and dust for later use; putting the drugs into a drug bag and tying, soaking in pure water for about half an hour (until the drug textures are penetrated), then, putting the soaked drugs and the clear liquor for soaking the drugs into a boiling machine, injecting cold boiled water which soaks the drugs by 36 mm to perform boiling for 35 times for a first time, filtrating the decoction, injecting slightly warm boiled water which soaks the drugs by 32 mm to perform boiling for 30 minutes for a second time, mixing and concentrating the decoction into 1200 ml of 50% traditional Chinese medicine liquor twice, packaging into bags and sealing, putting into a refrigerator, and retaining freshness for later use.

The invention relates to a modulator of nonsteroidal progesterone receptor with a structure of the general formula I or an acceptable salt on pharmacy and a preparation method thereof. The invention also relates to drug combination including compounds of the general formula I or an acceptable salt on pharmacy thereof and the antagonist activity of progesterone receptor which is provided by the compounds of the general formula I or the acceptable salt on pharmacy thereof; therefore, the invention can be used for preparing nonsteroidal drugs to prevent and (or) or treat symptoms or diseases such as secondary amenorrhea, functional bleeding disorder, uterine fibroids, endometriosis, polycystic ovary syndrome, breast cancer, contraceptive, induced labor, and termination of pregnancy, etc.

The invention discloses a menstruation-regulating and miscarriage-preventing traditional Chinese medicine composition which comprises a capsule and an efficacy-enhancing ingredient, wherein the capsule comprises the following raw materials: rheum officinale, Hannai agilawood, sangusis draconis, defatted croton seed powder, baked ginger, saffron crocus, angelica sinensis, ligusticum waliichii, rhizoma corydalis, peach kernels, colla corii asini, dried rhizome of rehmannia, pericarpium citri reticulatae, dendrobium and fingered citron; the efficacy-enhancing ingredient comprises the following raw materials: hematoxylon, costus roots, stigma croci, motherwort, salvia miltiorrhiza and brown sugar. The menstruation-regulating and miscarriage-preventing traditional Chinese medicine composition is scientifically compatible with traditional Chinese medicines, good in treatment effect, quick in effect, safe and reliable and free from toxic and side effects, realizes the effects of enriching blood, activating blood circulation to dissipate stasis, generating new blood, breaking extravagated blood, promoting the circulation of Qi and dredging stagnation, is effective for secondary amenorrhea and poor ovulation and can treat the female infertility caused by ovulatory dysfunction, tubal nowhere, menstrual disorder, dual depletion of Qi and blood and other problems.

The invention belongs to the field of traditional Chinese medicine and discloses a medicinal preparation for treating secondary amenorrhea caused by intrauterine adhesion. The medicinal preparation is prepared from, by weight, 15-25 parts of Chinese dodder seeds, 20-40 parts of Chinese wolfberry fruits, 10-20 parts of prepared rehmannia roots, 20-35 parts of abrus cantoniensis, 10-15 parts of euonymus oxyphyllus, 20-30 parts of conic gymnadenia tuber, 5-15 parts of licorice roots, 8-18 parts of cynanchum wilfordii, 10-20 parts of stellaria yunnanensis, 10-20 parts of Korean raspberry roots, 3-10 parts of bidentate achyranthes roots, 5-15 parts of nutgrass galingale rhizomes and 5-15 parts of fructus liquidambaris. The medicinal preparation has the effects of tonifying the kidney, nourishing the liver, promoting blood circulation to remove blood stasis and regulating thoroughfare and conception vessels, tonification and purgation are conducted in combination, and the curative effect is remarkable.

The invention relates to a traditional Chinese medicine for treating secondary amenorrhea. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 18-22 parts of radices trichosanthis, 10-14 parts of buffalo horn, 13-17 parts of cortex lycii radicis, 18-22 parts of radix ophiopogonis, 5-7 parts of cinnamon, 28-32 parts of semen plantaginis, 13-17 parts of radix polygonati officinalis, 9-11 parts of lotus plumule, 18-22 parts of herba lycopi and 28-32 parts of herba leonuri. The traditional Chinese medicine has the advantages of rich raw materials, low price, safe administration, no toxic or side effect and good using effect.

The invention provides a progesterone ethosome. Progesterone is encapsulated in an ethosome. The progesterone ethosome comprises the following components in percentage by weight: 0.1 to 1 percent of progesterone, 1 to 8 percent of lipid materials, 0 to 0.6 percent of cholesterol, 20 to 50 percent of short-chain alcohols, 0 to 3 percent of nonionic surfactant and the balance of water. The preparation method comprises the following steps of: mixing and dissolving the progesterone, the lipid materials, the cholesterol and the short-chain alcohols to prepare an alcohol phase; with stirring, adding the alcohol phase into a nonionic surfactant-containing aqueous phase to prepare primary emulsion under the condition of stirring; homogenizing the primary emulsion under a high pressure to obtain asuspension; stirring the ethosome suspension for 15 to 30 minutes to perform emulsification for the second time; and curing the suspension by cooling the suspension at 0 to 4 DEG C to obtain the progesterone ethosome. Because the high-pressure homogenization method is adopted to prepare the progesterone ethosome, the progesterone ethosome is low in stimulation to skin and high in transdermal delivery ability, and metal ion pollution which is easy to cause by the probe ultrasound method of the traditional homogenization method is avoided. Therefore, the progesterone ethosome is suitable for industrial production. The progesterone ethosome can be prepared into a transdermal drug delivery system, a mucosal drug delivery system, and topical dosage forms, such as a paster, a gel and the like. The progesterone ethosome is mainly applied to hormone replacement therapy, secondary amenorrhea, functional aplastic bleeding, premenstrual syndrome and the like clinically.

The invention discloses a traditional Chinese medicine for treating female infertility, which is prepared from the following raw materials in the weight ratio: 20-25 parts of rehmannia glutinosa, 10-15 parts of Codonopsis pilosula, 9-12 parts of angelica, and 5-7 parts of chuanxiong , 8-10 parts of Radix Paeoniae Alba, 8-10 parts of Morinda officinalis, 12-16 parts of Cyperus cyperi, 5-7 parts of fennel, 8-10 parts of psoralen, 3-5 parts of licorice, 8-10 parts of Wang Buliuxing 8-10 parts of medlar. The present invention selects 12 traditional Chinese medicines, which are scientifically compatible, have comprehensive medicinal effects, and have remarkable curative effects. The synergistic action of each raw material plays the role of enriching blood, promoting blood circulation and removing stasis, promoting qi circulation and unblocking stagnation, and is effective for secondary amenorrhea and poor ovulation. At the same time, it can nourish the kidney and yang, nourish the spleen and Qi, warm the kidney and nourish the liver, regulate menstruation and help pregnancy, and is effective for infertility due to kidney deficiency. The medicine of the invention treats both the symptoms and root causes, has good therapeutic effect, low cost and no toxic and side effects.

The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of these compounds are related to contraception, the treatment and / or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minication of side effects of cyclid menstrual bleeding. Additional uses of the invention include stimulation of food intake.

The invention discloses a traditional Chinese medicine composition for treating secondary amenorrhea. The traditional Chinese medicine composition is prepared from radix angelicae sinensis, radix rehmanniae, radix rehmanniae preparata, radix paeoniae alba, American ginseng, cornu cervi pantotrichum, semen cuscutae, flatstem milkvetch seeds, fructus amomi, fructus lycii, fructus corni, motherwort fruits, rhizoma atractylodis macrocephalae and rhizoma cyperi. The raw material medicines are mutually coordinated together, so that the medicine effect can be exerted to the greatest extent, the effects of tonifying liver and kidney, nourishing blood and replenishing essence, soothing liver and stimulating menstrual flow, regulating yin and yang and treating both symptoms and root causes are achieved, the use is convenient, and the electuary can be taken.

The invention discloses an oral marrow and Chinese date porridge for treating secondary amenorrhea and a preparation method thereof. The oral marrow and Chinese date porridge comprises the following components in parts by mass: 1-3 parts of porcine bone marrow, 1-3 parts of longan, 1-3 parts of Chinese date, 1-3 parts of pseudo-ginseng powder, and 1-3 parts of Chinese yam powder. The preparation method of the marrow and Chinese date porridge comprises the following steps: A, selecting high-quality, clean and first-grade porcine bone marrow, longan, Chinese date, pseudo-ginseng powder and Chinese yam powder in parts by mass, and respectively removing impurities and dust for standby application; B, placing the longan and Chinese date in a pot to be well stewed firstly, then, adding the porcine bone marrow, stewing for about ten minutes to enable the mixture to become pasty, adding the pseudo-ginseng powder and Chinese yam powder, uniformly stirring, insulating the mixture from a fire source, cooling to obtain 900 mL of the marrow and Chinese date porridge, and placing the marrow and Chinese date porridge into a refrigerator to be preserved for standby application.