Tumor microenvironment-responsive black phosphorus nanogel drug as well as preparation method and application thereof

A tumor microenvironment and nanogel technology, applied in the field of bio-nano medicine, can solve the problems of easy degradation of black phosphorus and black phosphorus nano-drug carriers, single types and functions of anti-tumor drugs, and low loading rate of non-ionic drugs. Achieve the effect of good anti-tumor effect in vitro, low cost and uniform particle size

Active Publication Date: 2020-12-18
深圳市泰韦尔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the present invention provides a tumor microenvironment-responsive black phosphorus nanogel drug, and the present invention also provides a method for preparing a tumor microenvironment-responsive black phosphorus nanogel drug, and the present invention also provides the The application of black phosphorus nanogel drugs that respond to the tumor microenvironment in the preparation of anti-tumor drugs to solve the problem of single types and functions of existing anti-tumor drugs. Black phosphorus and black phosphorus nano-drug carriers are easy to degrade and difficult to modify the surface. Defects such as low drug loading rate

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  • Tumor microenvironment-responsive black phosphorus nanogel drug as well as preparation method and application thereof
  • Tumor microenvironment-responsive black phosphorus nanogel drug as well as preparation method and application thereof
  • Tumor microenvironment-responsive black phosphorus nanogel drug as well as preparation method and application thereof

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[0036] In the second aspect, the present invention also provides a method for preparing a black phosphorus nanogel drug responsive to the tumor microenvironment, comprising the following steps:

[0037]Preparation of dextran-polyacrylate nanogel carrier solution: provide dextran aqueous solution, initiator aqueous solution, dimethyl sulfoxide solution of crosslinking agent and dimethyl sulfoxide solution of acrylate monomer, under inert gas Under protection, add the initiator aqueous solution to the dextran aqueous solution, stir and adjust the pH to acidic, then add the dimethyl sulfoxide solution of acrylate monomer to the dextran aqueous solution, stir and mix Finally, add the dimethyl sulfoxide solution of the cross-linking agent to the aqueous dextran solution, stir and react for 4 to 24 hours, then dialyze to obtain a dextran-polyacrylate nanogel carrier solution;

[0038] Prepare black phosphorus nanoparticle solution: provide black phosphorus powder and disperse it in ...

Embodiment 1

[0052] A method for preparing a black phosphorus nanogel drug responsive to the tumor microenvironment, comprising the following steps:

[0053] Raw material preparation: Dissolve 1.5 grams of dextran (molecular weight: 40,000 Da) in 30 milliliters of water and stir until fully dissolved to form an aqueous solution of dextran. 0.67 g of ceric ammonium nitrate was dissolved in water to prepare an aqueous solution of ceric ammonium nitrate. A dimethyl sulfoxide solution of diallyl disulfide was prepared by dissolving 0.144 g of diallyl disulfide crosslinking agent in 0.5 ml of dimethyl sulfoxide solution. A dimethyl sulfoxide solution of methyl acrylate monomer was prepared by dissolving 0.75 ml of methyl acrylate monomer in 2.5 ml of dimethyl sulfoxide.

[0054] Preparation of dextran-polyacrylate nanogel carrier solution: deoxidize with nitrogen for 1 hour, add an aqueous solution containing 0.67 g of ammonium cerium nitrate to the dextran aqueous solution under nitrogen prot...

Embodiment 2

[0060] A method for preparing a black phosphorus nanogel drug responsive to the tumor microenvironment, comprising the following steps:

[0061] Raw material preparation: Dissolve 1.5 grams of dextran (molecular weight: 40,000 Da) in 30 milliliters of water and stir until fully dissolved to form an aqueous solution of dextran. 0.67 g of ceric ammonium nitrate was dissolved in water to prepare an aqueous solution of ceric ammonium nitrate. A dimethyl sulfoxide solution of diallyl disulfide was prepared by dissolving 0.144 g of diallyl disulfide in 0.5 ml of dimethyl sulfoxide solution. 1.224 ml of glycidyl acrylate monomer was dissolved in 2.5 ml of dimethyl sulfoxide to prepare a dimethyl sulfoxide solution of glycidyl acrylate monomer.

[0062] Preparation of dextran-polyacrylate nanogel carrier solution: deoxidize with nitrogen for 1 hour, add an aqueous solution containing 0.67 g of ammonium cerium nitrate to the dextran aqueous solution under nitrogen protection and unifo...

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Abstract

The invention provides a tumor microenvironment-responsive black phosphorus nanogel drug. The tumor microenvironment-responsive black phosphorus nanogel drug comprises a glucan-polyacrylate nanogel carrier, a black phosphorus nanomaterial and an anti-cancer drug, wherein the black phosphorus nanomaterial and the anti-cancer drug are wrapped in the glucan-polyacrylate nanogel carrier; and the hydrodynamic diameter of the tumor microenvironment-responsive black phosphorus nanogel drug in an aqueous solution is less than or equal to 400 nm. The tumor microenvironment-responsive black phosphorus nanogel drug has the advantages of uniform particle size, good stability, excellent photothermal performance and the like, has good biocompatibility, has better in-vitro anti-tumor effect than non-tumor microenvironment-responsive black phosphorus nanogel drugs, and has wide application prospects in the field of photothermal chemotherapy combined treatment of cancers. The invention also provides apreparation method and application of the tumor microenvironment-responsive black phosphorus nanogel drug.

Description

technical field [0001] The invention relates to the technical field of bio-nano medicine, in particular to a black phosphorus nanogel drug responsive to the tumor microenvironment, and the invention also relates to a preparation method of the black phosphorus nanogel drug responsive to the tumor microenvironment and the tumor microenvironment responsive drug. The application of the black phosphorus nanogel drug in the preparation of antitumor drugs. Background technique [0002] In recent years, photothermal therapy has become one of the most promising cancer treatment methods due to its advantages of non-invasiveness, high efficiency, simple procedure, fast recovery and few complications. Common photothermal materials cannot meet clinical needs due to their poor water solubility, degradability, long-term biological safety, low tissue penetration and photothermal conversion efficiency (Biomaterials 2018, 155, 217, Chem Soc Rev 2018 ,47,2280). In addition, commonly used ino...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K31/7048A61K31/337A61K31/475A61K31/7068A61K38/14A61K9/06A61K47/36A61K47/32A61P35/00
CPCA61K41/0052A61K31/704A61K31/7048A61K31/337A61K31/475A61K31/7068A61K38/14A61K9/06A61K47/36A61K47/32A61P35/00A61K2300/00
Inventor 张晗赵军罗小玲王灏张家宜
Owner 深圳市泰韦尔生物科技有限公司
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