Celastrus angulatus active compound, emulsion in water and preparation method thereof

A technology of picroderm and water emulsion, applied in the field of plant pesticides, can solve the problems of low content of active ingredients, single preparation, large pollution, etc., and achieve the effect of simple operation, simple process and reduced usage

Pending Publication Date: 2021-01-22
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the defects of low content of active ingredients, single preparation and relatively large pollution of the existing botanical insecticide phalanthin, the present invention provides a high-content phalaetanin and a new low-pollution phalaetum plain water emulsion

Method used

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  • Celastrus angulatus active compound, emulsion in water and preparation method thereof
  • Celastrus angulatus active compound, emulsion in water and preparation method thereof
  • Celastrus angulatus active compound, emulsion in water and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) Preparation of the original drug of phareidin

[0049] Weigh 20g of bitter bark root bark from Gansu, crush it through a 30-mesh sieve, put it into a 500mL reaction bottle, add 125g of toluene, 135g of xylene, heat to 90°C and stir for 5 hours, cool and filter, collect the filtrate, repeat the operation three times to combine The filtrate was evaporated and desolvated to obtain 2.01g of extract, added 4g of silica gel (fineness: about 300 mesh, the same below) to absorb, put it into a chromatographic column (1.5×30cm, filled with 30g of silica gel), rinsed with 300mL of absolute ethanol, The eluents were combined, and 1.76 g of solids were obtained by desolventization. Add 3 g of silica gel for adsorption and put them into a chromatographic column (1.5 × 30 cm, filled with 30 g of silica gel) for chromatographic separation. Use petroleum ether-ethyl acetate system, 10:1 (volume ratio, the same below) to collect 1 to 3 copies (20 mL each, the same below); 8:1 to coll...

Embodiment 2

[0078] The preparation method and stability analysis of the original medicine of picroderm and emulsion in water

[0079] (1) Paretinin original drug

[0080] Weigh 100g of vine roots and bark purchased from Hubei, crush them through a 30-mesh sieve, put them into a 2000mL reaction bottle, add 250g of toluene, 350g of xylene, heat to 90°C and reflux for 4 hours, cool and filter, collect the filtrate, repeat the operation three times to combine The filtrate was evaporated and desolvated to obtain 12.6g of extract, added 20g of silica gel (fineness is about 300 mesh, the same below) to absorb, put it into a chromatographic column (3×60cm, filled with 100g of silica gel), rinsed with 500mL of absolute ethanol, The eluents were combined, and 11.2 g of solids were obtained by desolventization. After being absorbed by 15 g of silica gel, they were loaded into a chromatographic column (3×60 cm, filled with 100 g of silica gel) for chromatographic separation, using petroleum ether-eth...

Embodiment 3

[0109] Screening of Surfactants for Erythrocetin in Water Emulsion

[0110] Take 3.72g of the homemade phaelopedin original drug, add 21.2g of surfactant, heat to 51°C, stir (1500r / min) for 10 minutes to obtain an organic phase, mix 4.8g of ethylene glycol, 0.25g of xanthan gum, 0.1g silicone antifoam agent, make up tap water to 120g and combine to obtain the water phase, at a temperature of 55°C, under stirring (2500r / min), slowly and evenly add the water phase (3 drops per second) to the organic phase, drop Continue to stir for 20 minutes after the addition to obtain an emulsion, and ultrasonicate the emulsion on a high-speed ultrasonic homogenizer (frequency 20KHz) for 8 minutes to obtain a phaevalin aqueous emulsion.

[0111] The surfactants used are as shown in the figure below, and the emulsion stability test is carried out according to GB-T1603-2001; the low-temperature stability test is carried out according to GB-T19137-2003; the high-temperature storage stability tes...

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Abstract

The invention belongs to the technical field of plant pesticides, and particularly provides a celastrus angulatus active compound, an emulsion in water and a preparation method thereof. The celastrusangulatus active compound is prepared through cooking, degreasing and column chromatography, and after the celastrus angulatus active compound and an organic solvent are mixed and stirred through a phase transformation method, water, a non-ionic surfactant, a thickening agent, an anti-freezing agent and a defoaming agent are added with stirring at a controlled temperature, and ultrasonic homogenization and crushing are performed to finally obtain the celastrus angulatus emulsion in water. The emulsion in water comprises the following components in percentage by mass: 2-5% of celastrus angulatus active compound, 5-15% of an organic solvent, 5-10% of a nonionic surfactant, 0.1-0.5% of a colloid protective agent, 2-6% of a freezing inhibitor, 0.1-0.3% of an organic silicon anti-foaming agentand the balance of water. The celastrus angulatus active compound is simple and easy to operate, high in content of effective active ingredients, small in use amount of an emulsion in water solvent, almost odorless, good in dispersity and good in stability, and is not caked or layered after passing a hot and cold storage test.

Description

technical field [0001] The invention belongs to the technical field of plant pesticides, and in particular relates to an insecticide pectin, an emulsion in water and a preparation method thereof. Background technique [0002] In recent years, with the growing calls for environmental protection, the use of highly toxic pesticides has drawn widespread attention. With the accumulation of time, more and more people realize that chemically developed pesticides will have pesticide residues that are difficult to remove and will also pose a threat to birds and animals that are not harmful to crops. More importantly, the abuse of chemical pesticides It will cause irreversible damage to the ecological environment. Therefore, pesticide workers from all over the world are devoting themselves to the development of new pesticides with high efficiency, low toxicity and low residue. [0003] Botanical pesticides refer to a class of plant pesticides prepared by extracting active ingredient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/94A01N25/04A01N43/12A01P7/04
CPCC07D307/94A01N25/04A01N43/12
Inventor 徐德锋王秦胡航
Owner CHANGZHOU UNIV
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