30results about How to "Suitable for magnification" patented technology

The invention discloses a high-capacity carbon-silicon negative electrode active material and preparation and application methods thereof. The high-capacity carbon-silicon negative electrode active material achieves a specific capacity of 800-1500 mAh / g and is formed by mixing carbon-silicon materials and graphite materials, wherein the carbon-silicon materials are microspherical particles prepared by performing ball milling spray-drying and thermal treatment processes on nanosilicon, crystalline flake graphite, carbon nanotubes and a carbon source, the nanosilicon is dispersed on the surfaceof the crystalline flake graphite, the carbon nanotubes are inserted into pores formed between the carbon nanotubes and the crystalline flake graphite, pyrolytic carbon of the carbon source is coatedon the surface of the nanosilicon and the surface and pores of the spherical particles formed by the nanosilicon, the crystalline flake graphite and the carbon nanotubes; the weight of silicon-carbonmaterials is 25%-80% of the total weight of the high-capacity carbon-silicon negative electrode active material. When uniformly mixed with conducting agent and bonding agent, the high-capacity carbon-silicon negative electrode active material can be coated or deposited onto copper foils, foamed nickel, foamed copper or carbon fiber paper as the negative electrode of a lithium ion battery. The preparation method of the high-capacity carbon-silicon negative electrode active material is simple in process, low in cost, applicable to amplified preparation of long-circulation carbon-silicon materials.

The invention relates to methanol-to-gasoline catalysts, in particular to a ZSM-5 / MCM-48 composite molecular sieve, a preparation method and application thereof. The composite molecular sieve adopts a ZSM-5 microporous molecular sieve as the seed crystal, on the surface of which a MCM-48 mesoporous structure composite molecular sieve that is chemically interlinked at a mesoporous and micropore interface is obtained by overgrowth. The composite molecular sieve undergoes acidification, and then is mixed with a binder to undergo molding and roasting, and the product is used as a catalyst for methanol-to-gasoline (MTG) reaction. The catalyst provided by the invention is used for overgrowth of the mesoporous molecular sieve on the microporous molecular sieve surface, integrates the advantages of the microporous material and the mesoporous material so as to develop the strong points and avoid the weak points and reach a synergistic effect. The catalyst shows good catalytic properties to the methanol-to-gasoline (MTG) reaction, has high selectivity to gasoline products and a low aromatic hydrocarbon content, and extends the carbon chain length. More importantly, the problems of high reaction temperature, high aromatic hydrocarbon content in oil products, and limitation of hydrocarbon compounds only to less than C11 in traditional MTG technologies are solved.

The invention relates to a docetaxel liposome sterile lyophilized preparation and preparation method thereof, and the docetaxel liposome sterile lyophilized preparation comprises docetaxel, natural lecithin, PEG-DSPE, cholesterol, a protective agent for lyophilization, and buffer salts. The natural lecithin, PEG-DSPE, cholesterol, and docetaxel are dissolved in a organic solvent; a buffer solution containing the protective agent for lyophilization is added into mixed solution; the solution is incubated for 10-60 min for decreasing the average particle size of the liposome to 50-200 nm; and the preparation is obtained after bacilli-eliminated filtration and lyophilization. The docetaxel liposome prepared by the invention has the advantages of less toxic and side effect and higher curative effect when compared with commercially available ordinary injections at present. The preparation method of the invention is simple and practical, and is applicable to industrial production; and the prepared docetaxel liposome has high encapsulation efficiency and good stability.

The invention discloses a polymer microsphere and preparation method and application thereof. Polystyrene is used for making a base sphere with the surface comprising a condensed-nuclei aromatic structure in pi-pi interaction with fullerene, and the structure is obtained by substituting a hydrogen atom on a benzene ring contained in the base sphere by chloromethyl and reacting with condensed-nuclei aromatics. The method includes: using a monodispersed polystyrene microsphere as the base sphere, mixing with catalyst SnCl4, adding aliphatic halogenate varsol, slowly dripping chloromethylation reagent while stirring for substitution reaction, allowing the reacted microsphere to react with the condensed-nuclei aromatics, and washing and drying the obtained microsphere to obtain a polymer microsphere with a fullerene separated liquid chromatographic stationary phase serving as a mobile phase. The preparation method of the surface modified polystyrene polymer microsphere only needs two steps, is simple in process, easy to repeat, suitable for massive production of fullerene and has the advantages of high separation efficiency and effectiveness.

The invention discloses a method for preparing benzalacetone under the supercritical condition. According to the conventional synthetic method, reaction is realized by an autoclave, and is intermittent, low in space time yield of the reaction and high in energy consumption. According to the method, the benzalacetone is prepared by performing the one-step condensation reaction of benzaldehyde and acetone which serve as raw materials under the supercritical condition, wherein the conversion rate of the benzaldehyde is over 99 percent, and the reaction yield of the benzaldehyde is over 92 percent. According to method, other solvents and acid or base catalysts are not needed to be added, the residual acetone can be recycled directly, so the method has the advantages of environment friendliness, no pollution, high selectivity and the like.

The invention relates to a 2-amino-N-(2-chloro-6-methyl phenyl)thiazole-5-carboxamide synthesis method, wherein the compound 2-amino-N-(2-chloro-6-methyl phenyl)thiazole-5-carboxamide is a key intermediate for synthesizing dasatinib. The synthesis method comprises that: 1) trichloroacetyl chloride and ethyl vinyl ether are subjected to a nucleophilic substitution and hydrolysis reaction one-pot method to synthesize 3-ethoxyacrylic acid; 2) 3-ethoxyacrylic acid is subjected to an acyl chlorination and amidation reaction one-pot method to synthesize N-(2-chloro-6-methyl phenyl)-3-ethoxy acrylamide; and 3) N-(2-chloro-6-methyl phenyl)-3-ethoxy acrylamide, NBS and thiourea are subjected to a reaction to obtain 2-amino-N-(2-chloro-6-methyl phenyl)thiazole-5-carboxamide. The synthesis method has characteristics of yield increase, cost reduction, operation simplifying, and high implementation value.

The invention provides a synthesis method of 2-bromo-9,9-diphenylfluorene and belongs to the technical field of organic synthesis. The synthesis method comprises steps as follows: (1), after 2-bromo-9-phenyl-fluorene-9-ol and benzene are mixed, reaction gas is introduced for a reaction at the temperature of 61-66 DEG C while the components are stirred, the temperature is increased and backflow is performed after gas introduction is finished, and water is separated while backflow is performed; (2), a catalyst is added in 0.5-1 h after a system obtained from the step (1) is cooled, the temperature is increased to 35-50 DEG C, and the mixture reacts for 3.5-5 h; (3), 2-bromo-9,9-diphenylfluorene is obtained through separation and purification. The synthesis method of 2-bromo-9,9-diphenylfluorene is low in cost, especially when hydrogen chloride and hydrogen bromide are utilized; with the adoption of an aluminum trichloride anhydrous and ferric chloride anhydrous mixed catalysis mode, the catalysis effect is good, the reaction time is short, and the yield is high; the operation is simple, the process is reliable, and scale-up is facilitated.

The invention belongs to the field of hydrogen production and chemical equipment, and in particular, relates to a heat-exchange sulfuric acid catalytic decomposition reactor comprising a shell, a gasguide plate, a bayonet tube internal heat exchange type sulfuric acid decomposition assembly, a heat insulation layer and a feeding and discharging part; the gas guide plate forms a heat exchange chamber; an annular gap is formed between the gas guide plate and the shell; the lower end of the gas guide plate abuts against the heat-insulating layer; the lower end of the gas guide plate communicateswith the annular gap; the annular gap communicates with the heating gas outlet; the feeding and discharging part is connected with the bottom end of the shell and provided with a sulfuric acid feeding port and a product outlet; the bayonet tube internal heat exchange type sulfuric acid decomposition assembly penetrates through the heat insulation layer to communicate with the feeding and discharging part, an annular gap between an inner tube and an outer tube of the bayonet tube internal heat exchange type sulfuric acid decomposition assembly communicates with the sulfuric acid feeding port,and an inner tube of the reaction tube communicates with the product outlet. According to the heat-exchange sulfuric acid catalytic decomposition reactor, high-temperature gas can be used as a heatingmedium to realize efficient catalytic decomposition of sulfuric acid.

The invention discloses a synthesis method of rosuvastatin tert-butyl ester. The synthesis method comprises the following steps: reacting 5-bromomethyl-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methanesulfonyl)amino]pyrimidine with a substance A under the action of a first base catalyst to obtain a substance B; oxidizing the substance B with an oxidizing agent to obtain a substance C; then, reacting the substance C with tert-butyl (4R-Cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetate under the action of a second base catalyst to obtain a substance D; and finally, performing acid deprotection toobtain the rosuvastatin tert-butyl ester. The method disclosed by the invention is green and environment-friendly, mild and controllable in reaction condition, convenient and simple to operate, good in stereoselectivity and high in yield, and the prepared rosuvastatin tert-butyl ester is good in purity.

The invention discloses a micro-nano structure Al-FeF3 compound fuel and a preparation method thereof. The method includes the steps: adding aluminum powder, additives FeF3 and stearic acid into a planetary ball mill, and performing high-energy ball milling according to the ratio of grinding media to materials and process parameters; taking out materials, adding organic solvents, and naturally drying the materials to achieve passivation of the materials; cleaning the materials by the organic solvents, drying the cleaned materials, and packaging the dried materials. In the aspects of a structure and a form, the prepared micro-nano structure Al-FeF3 compound fuel has the advantages that the aluminum powder has a micron-sized form and accounts for 95% or more of the weight of the compound fuel, the additives FeF3 have a nano-sized form and are uniformly embedded into surface layers and the inside of the aluminum powder, the additives FeF3 can serve as metal fuels for solid rocket propellants to replace the aluminum powder, so that an ignition point of the aluminum powder can be reduced, low-temperature oxidation performance of the aluminum powder is improved, and two-phase loss of a rocket nozzle is reduced. A preparation process of the compound fuel is simple, preparation devices are mature, and industrial amplification can be achieved under a certain scale.

The invention discloses a high-capacity silicon-carbon negative electrode active material and its preparation method and application. The high-capacity silicon-carbon negative electrode active material has a specific capacity of 800-1500mAh / g, and is formed by mixing silicon-carbon materials and graphite materials. Silicon carbon material is prepared from nano-silicon, flake graphite, carbon nanotubes and carbon source through ball milling, spray drying and heat treatment to obtain microspherical particles, in which nano-silicon is dispersed on the surface of flake graphite, and carbon nanotubes are interspersed between carbon nanotubes and flake graphite In the formed pores, pyrolytic carbon from carbon sources is coated on the surface of nano-silicon, and the surface and pores of spherical particles formed by nano-silicon, flake graphite and carbon nanotubes; silicon-carbon materials account for the total of high-capacity silicon-carbon negative electrode active materials. 25% to 80% of the mass. The active material is uniformly mixed with a conductive agent and a binder, and coated or deposited on copper foil, nickel foam, copper foam or carbon fiber paper to be used as a negative electrode of a lithium ion battery. The preparation method of the invention has simple process, low cost and is suitable for large-scale preparation of long-cycle and silicon-carbon materials.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a lyophilized preparation of metabolic modulatory fusion protein. The lyophilized preparation is a freeze-dried FGF21 Fc fusion protein preparation which takes a composition of hydroxyethyl starch and sodium glutamate as a protective agent, and is good in stability, full in appearance and uniform in texture. In addition, a preparation method of the lyophilized preparation is simple in process, suitable for amplification, controllable in quality, and good in drying effect; and the lyophilized preparation prepared by the preparation method is low in water content, as well as convenient to store and transport.

The invention relates to a one-pot method for preparing 2-bromo-9,9-diphenylfluorene and belongs to the technical field of organic synthesis. The method comprises steps shown in the specification. The reaction can be finished in one reactor, particularly for a chlorination reaction, intermediate products are not required to be separated out, a subsequent reaction of replacement of chlorine atoms with benzene rings is performed after a system reactant and a catalyst are directly added, the whole operation is simple, and the technology is reliable and suitable for enlargement; besides, by means of the used catalyst, side reactions can be effectively reduced, the product yield is increased to be higher than 90%, meanwhile, separation can be realized through filtration after the reaction due to the fact that the catalyst is a solid catalyst, and the after-treatment process is simplified.

The invention discloses a preparation method for a novel ZIFs membrane containing zinc adopting sandwich structure and supported by a high temperature resistant zinc oxide nanorod. According to the invention, by introducing a layer of zinc oxide nanorod on a porous carrier as a bridge to connect the carrier and the ZIFs membrane to construct to form the sandwich structural membrane supported by the zinc oxide nanorod. The zinc oxide nanorod has the following functions: 1, modifying the carrier surface to facilitate the uniform growth of the ZIFs membrane; 2, acting as homogeneous phase induction nucleation growing point of the continuous growth of the ZIFs membrane to guarantee the complete formation of the membrane with high sieving property; acting as bridging liking effect between the carrier and the membrane layer to solve the combination problem between the membrane and the carrier and guarantee high stability of the membrane. Compared with a traditional preparation method of a ZIFs membrane, the membrane prepared by the invention not only has high separating property, high temperature resistance, but also has simple process, good repeatability, convenience in amplification of large-scale preparation, and wide application prospect.

The invention discloses a method for preparing raspberry ketone under a supercritical condition. P-hydroxy benzaldehyde and acetone are used as raw materials, an aromatic solvent is used as a solvent,a condensation reaction is conducted continuously in a pipeline reactor, p-hydroxybenzal vinylmethylketone is obtained in the absence of a catalyst, then, a methanol solution of p-hydroxybenzal vinylmethylketone and hydrogen are subjected to a hydrogenation reduction reaction in a tank reactor under the action of a nickel catalyst to produce raspberry ketone. The preparation method solves the environmental protection problem, has the advantages that the process is simple, acid or base catalysts are not used, few three wastes are produced, the yield is high and enlargement is easy and has higher industrial application values.

The invention relates to methanol-to-gasoline catalysts, in particular to a ZSM-5 / MCM-48 composite molecular sieve, a preparation method and application thereof. The composite molecular sieve adopts a ZSM-5 microporous molecular sieve as the seed crystal, on the surface of which a MCM-48 mesoporous structure composite molecular sieve that is chemically interlinked at a mesoporous and micropore interface is obtained by overgrowth. The composite molecular sieve undergoes acidification, and then is mixed with a binder to undergo molding and roasting, and the product is used as a catalyst for methanol-to-gasoline (MTG) reaction. The catalyst provided by the invention is used for overgrowth of the mesoporous molecular sieve on the microporous molecular sieve surface, integrates the advantages of the microporous material and the mesoporous material so as to develop the strong points and avoid the weak points and reach a synergistic effect. The catalyst shows good catalytic properties to the methanol-to-gasoline (MTG) reaction, has high selectivity to gasoline products and a low aromatic hydrocarbon content, and extends the carbon chain length. More importantly, the problems of high reaction temperature, high aromatic hydrocarbon content in oil products, and limitation of hydrocarbon compounds only to less than C11 in traditional MTG technologies are solved.

The invention provides a synthesis method of 2-bromo-9,9-diphenylfluorene and belongs to the technical field of organic synthesis. The synthesis method comprises steps as follows: (1), after 2-bromo-9-phenyl-fluorene-9-ol and benzene are mixed, reaction gas is introduced for a reaction at the temperature of 61-66 DEG C while the components are stirred, the temperature is increased and backflow is performed after gas introduction is finished, and water is separated while backflow is performed; (2), a catalyst is added in 0.5-1 h after a system obtained from the step (1) is cooled, the temperature is increased to 35-50 DEG C, and the mixture reacts for 3.5-5 h; (3), 2-bromo-9,9-diphenylfluorene is obtained through separation and purification. The synthesis method of 2-bromo-9,9-diphenylfluorene is low in cost, especially when hydrogen chloride and hydrogen bromide are utilized; with the adoption of an aluminum trichloride anhydrous and ferric chloride anhydrous mixed catalysis mode, the catalysis effect is good, the reaction time is short, and the yield is high; the operation is simple, the process is reliable, and scale-up is facilitated.

The invention relates to an iron-loaded graphene-based tungsten disulfide nano lubricant additive and a preparation method thereof. The preparation method comprises the following steps of adding a tungsten source and a sulfur source into water to be dissolved, then mixing a tungsten source aqueous solution and a sulfur source aqueous solution according to a certain proportion, and adjusting the mixed solution to be acidic, adding graphene oxide into the solution, carrying out ultrasonic treatment, and reacting under the conditions that the temperature is 170-200 DEG C and the pressure is 2-4 MPa, cooling the reaction liquid, and then centrifugally washing and freeze-drying to obtain the graphene oxide-based tungsten disulfide composite nanomaterial, adding the graphene oxide-based tungsten disulfide composite nanomaterial into a soluble ferric salt solution, carrying out ultrasonic treatment, heating to 80-100 DEG C, adding a strong alkali solution under a stirring condition to adjust the mixed solution to be neutral or alkaline, and carrying out a reflux reaction, after the reaction liquid is cooled, centrifugal washing and drying, finally, heating a dried product to 300-400 DEG C under the protection of nitrogen for calcination, and preparing the iron-loaded graphene-based tungsten disulfide nano lubricant additive.

The invention discloses a micro-nano structure Al-FeF3 compound fuel and a preparation method thereof. The method includes the steps: adding aluminum powder, additives FeF3 and stearic acid into a planetary ball mill, and performing high-energy ball milling according to the ratio of grinding media to materials and process parameters; taking out materials, adding organic solvents, and naturally drying the materials to achieve passivation of the materials; cleaning the materials by the organic solvents, drying the cleaned materials, and packaging the dried materials. In the aspects of a structure and a form, the prepared micro-nano structure Al-FeF3 compound fuel has the advantages that the aluminum powder has a micron-sized form and accounts for 95% or more of the weight of the compound fuel, the additives FeF3 have a nano-sized form and are uniformly embedded into surface layers and the inside of the aluminum powder, the additives FeF3 can serve as metal fuels for solid rocket propellants to replace the aluminum powder, so that an ignition point of the aluminum powder can be reduced, low-temperature oxidation performance of the aluminum powder is improved, and two-phase loss of a rocket nozzle is reduced. A preparation process of the compound fuel is simple, preparation devices are mature, and industrial amplification can be achieved under a certain scale.

The invention discloses a method for preparing benzalacetone under the supercritical condition. According to the conventional synthetic method, reaction is realized by an autoclave, and is intermittent, low in space time yield of the reaction and high in energy consumption. According to the method, the benzalacetone is prepared by performing the one-step condensation reaction of benzaldehyde and acetone which serve as raw materials under the supercritical condition, wherein the conversion rate of the benzaldehyde is over 99 percent, and the reaction yield of the benzaldehyde is over 92 percent. According to method, other solvents and acid or base catalysts are not needed to be added, the residual acetone can be recycled directly, so the method has the advantages of environment friendliness, no pollution, high selectivity and the like.

The invention provides a porous carbon supported trimanganese tetraoxide nanoparticle composite material and a preparation method thereof. The composite material is prepared from, by weight, 50%-80% of trimanganese tetraoxide nanoparticles and 20%-50% of three-dimensional porous carbon material stent prepared from ginkgo leaves. When the composite material is prepared, manganese acetate and potassium hydroxide are added into the three-dimensional porous carbon material stent according to the stoichiometric ratio of carbon to trimanganese tetroxide, and the composite material is obtained after reacting is conducted. According to the porous carbon supported trimanganese tetraoxide nanoparticle composite material, the reversible capacity of the composite material can reach 500 mAh / g or above after charging and discharging are conducted 50 times under the electric current density of 100 mA.g<-1>.

The invention relates to a 2-amino-N-(2-chloro-6-methyl phenyl)thiazole-5-carboxamide synthesis method, wherein the compound 2-amino-N-(2-chloro-6-methyl phenyl)thiazole-5-carboxamide is a key intermediate for synthesizing dasatinib. The synthesis method comprises that: 1) trichloroacetyl chloride and ethyl vinyl ether are subjected to a nucleophilic substitution and hydrolysis reaction one-pot method to synthesize 3-ethoxyacrylic acid; 2) 3-ethoxyacrylic acid is subjected to an acyl chlorination and amidation reaction one-pot method to synthesize N-(2-chloro-6-methyl phenyl)-3-ethoxy acrylamide; and 3) N-(2-chloro-6-methyl phenyl)-3-ethoxy acrylamide, NBS and thiourea are subjected to a reaction to obtain 2-amino-N-(2-chloro-6-methyl phenyl)thiazole-5-carboxamide. The synthesis method has characteristics of yield increase, cost reduction, operation simplifying, and high implementation value.

The invention relates to a docetaxel liposome sterile lyophilized preparation and preparation method thereof, and the docetaxel liposome sterile lyophilized preparation comprises docetaxel, natural lecithin, PEG-DSPE, cholesterol, a protective agent for lyophilization, and buffer salts. The natural lecithin, PEG-DSPE, cholesterol, and docetaxel are dissolved in a organic solvent; a buffer solution containing the protective agent for lyophilization is added into mixed solution; the solution is incubated for 10-60 min for decreasing the average particle size of the liposome to 50-200 nm; and the preparation is obtained after bacilli-eliminated filtration and lyophilization. The docetaxel liposome prepared by the invention has the advantages of less toxic and side effect and higher curative effect when compared with commercially available ordinary injections at present. The preparation method of the invention is simple and practical, and is applicable to industrial production; and the prepared docetaxel liposome has high encapsulation efficiency and good stability.

The invention belongs to the technical field of protein and polypeptide drugs, and particularly relates to a freeze-dried powder preparation of metabolic regulation fusion protein, which comprises FGF21-Fc fusion protein, a protective agent, a buffer agent and a solubilizer, the preparation method of the preparation, particularly a freeze-drying process, is optimized to obtain the stable FGF21-Fcfusion protein freeze-dried preparation. The freeze-dried preparation prepared by the invention has few auxiliary materials, the potential safety hazard of clinical medication is further reduced, andthe obtained preparation is full in appearance, uniform in texture, rapid in redissolution, good in stability and convenient to store and transport, and the moisture content is lower than 1%.

The invention belongs to the technical field of plant pesticides, and particularly provides a celastrus angulatus active compound, an emulsion in water and a preparation method thereof. The celastrusangulatus active compound is prepared through cooking, degreasing and column chromatography, and after the celastrus angulatus active compound and an organic solvent are mixed and stirred through a phase transformation method, water, a non-ionic surfactant, a thickening agent, an anti-freezing agent and a defoaming agent are added with stirring at a controlled temperature, and ultrasonic homogenization and crushing are performed to finally obtain the celastrus angulatus emulsion in water. The emulsion in water comprises the following components in percentage by mass: 2-5% of celastrus angulatus active compound, 5-15% of an organic solvent, 5-10% of a nonionic surfactant, 0.1-0.5% of a colloid protective agent, 2-6% of a freezing inhibitor, 0.1-0.3% of an organic silicon anti-foaming agentand the balance of water. The celastrus angulatus active compound is simple and easy to operate, high in content of effective active ingredients, small in use amount of an emulsion in water solvent, almost odorless, good in dispersity and good in stability, and is not caked or layered after passing a hot and cold storage test.