Codonopsis pilosula alkyne glycoside sustained-release micro-capsule preparation and preparation method thereof

A technology of Codonopside and sustained-release, which is applied in the field of Codonopside sustained-release microcapsule preparation and its preparation, can solve the problem of not finding a patent for sustained-release preparation, and achieve the advantages of adaptability, reduce the number of doses, and shorten the half-life. Effect

Active Publication Date: 2021-01-29
SHANGHAI NUOCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] So far, no patents on sustained-release prep...

Method used

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  • Codonopsis pilosula alkyne glycoside sustained-release micro-capsule preparation and preparation method thereof
  • Codonopsis pilosula alkyne glycoside sustained-release micro-capsule preparation and preparation method thereof
  • Codonopsis pilosula alkyne glycoside sustained-release micro-capsule preparation and preparation method thereof

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preparation example Construction

[0052] The embodiment of the present invention relates to a slow-release microcapsule preparation and a preparation method of a tangshenoside compound, in terms of weight percentage, comprising:

[0053] Codonopsis: 10%-40%;

[0054] Capsule material: 60%-90%;

[0055] The ratio of the capsule material to the styoside is 4:1-6:1;

[0056] The capsule material is a positively and / or negatively charged carrier material;

[0057] The capsule material also includes curing cross-linking agent, wetting agent, pH regulator and deionized water.

[0058] The capsule material is gelatin or one or more combinations of gum arabic, peach gum, psyllium seed gum, cellulose acetate phthalate, sodium carboxymethyl cellulose and alginate.

[0059] Among them, gelatin is a positively charged capsule material.

[0060] Among them, gum arabic, peach gum, psyllium seed gum, cellulose acetate phthalate, sodium carboxymethyl cellulose, and alginate are negatively charged capsule materials.

[00...

Embodiment 1

[0078]

[0079] Add gelatin to 1% calcium chloride solution, add hydrochloric acid solution dropwise to adjust the pH value to 6.1, and obtain the first capsule material solution; prepare sodium alginate into a 3 mg / ml solution, add tangshenoside, stir and mix, And keep the solution temperature at 50° C. to obtain the second capsule material solution. Place the first capsule material solution on a magnetic stirrer, set the stirring speed at 300rpm under the condition of 50°C, slowly add the above-mentioned second capsule material solution into capsule material solution 1, stir for 30 minutes, cool down, and let it stand After settling, the supernatant was decanted, washed with water, filtered, and the obtained microcapsules were vacuum-dried at 50°C. bottling. The yield of tangshenoside sustained-release microcapsules was 90.8%, the encapsulation rate was 74.3%, the drug loading was 21.7%, the cumulative release rate in 4 hours was 45.5%, and the cumulative release rate in...

Embodiment 2

[0081]

[0082] Dissolve gelatin in a water bath at 50°C to prepare a 30 mg / ml solution to obtain capsule material solution 1; weigh tangshenoside and gum arabic, slowly add a small amount of water at 50°C, grind evenly, transfer to a beaker, add water To a sufficient amount of 835ml, put it on a magnetic stirrer, set the stirring speed to 500rpm, and the temperature to 50°C; slowly add the gelatin solution, and stir for 30 minutes. Acetic acid solution was added dropwise to adjust the pH value to 3.8, and stirring was continued for 20 minutes. After forming capsules, add water to dilute 2 times, and then rapidly cool down to below 10°C in an ice bath. Add formaldehyde solution, adjust the pH value to 8.6 with 20% sodium carbonate solution, stir for 10 minutes, let it settle, pour off the supernatant, filter, wash with water, and the obtained microcapsules are vacuum-dried at 50°C. bottling. The yield of tangshenoside sustained-release microcapsules was 89.4%, the encapsu...

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Abstract

The invention relates to the technical field of preparation of compounds and particularly relates to a codonopsis pilosula alkyne glycoside sustained-release microcapsule and a preparation method thereof. The codonopsis pilosula alkyne glycoside sustained-release microcapsule comprises the following components of codonopsis pilosula alkyne glycoside and a capsule wall material. A wetting agent, acuring cross-linking agent and a pH regulator are also used in the encapsulation process. The preparation process comprises the following steps of dissolving a capsule material in water to obtain a capsule material solution, wetting the capsule material solution with a wetting agent, and regulating the pH value to 3.5-4.5 with a pH regulator at the solution temperature of 35-70 DEG C; the codonopsis pilosula alkyne glycoside sustained-release micro-capsule provided by the invention is better in component ratio, the prepared sustained-release micro-capsule is good in sustained-release effect and good in dispersion performance in water, stability of the medicine is improved, compliance of a patient is enhanced, and the codonopsis pilosula alkyne glycoside sustained-release micro-capsule is used for treating acute injury of gastric mucosa.

Description

technical field [0001] The embodiment of the present invention relates to a herbal drug extract, more specifically to a tangshenoside sustained-release microcapsule preparation and a preparation method thereof. Background technique [0002] Codonopsis pilosula has the functions of invigorating the spleen and lungs, nourishing blood and promoting body fluid. It is used for deficiency of spleen and lung qi, fatigue due to lack of food, cough and shortness of breath, deficiency of qi and blood, pale complexion, palpitation, shortness of breath, thirsty body fluid wound, internal heat and quenching thirst. Studies have shown that Codonopsis decoction has effects on the central nervous system, blood and hematopoietic system, digestive system, endocrine system and immune system. Modern research shows that Codonopsis decoction can prevent coronary heart disease, treat hyperlipidemia, treat hypotension, treat hematopoietic dysfunction caused by chemotherapy, treat dysfunctional ute...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61K9/62A61K9/26A61P1/04A61P9/12A61P13/08A61P25/20A61P29/00A61P31/04A61P35/00A61K47/36A61K47/38
CPCA61K31/7032A61P35/00A61P31/04A61P29/00A61P25/20A61P9/12A61P13/08A61P1/04A61K9/5084A61K9/2081A61K9/5042A61K9/5036A61K9/5047Y02A50/30
Inventor 胡炜
Owner SHANGHAI NUOCHENG PHARMA
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