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Method for improving surface loading capacity of rare earth fluoride nano material

A technology of rare earth fluorides and nanomaterials, applied in chemical instruments and methods, luminescent materials, nanotechnology, etc., can solve the problem of difficult to achieve particle size and uniform particle preparation, large changes in particle size of rare earth fluoride nanoparticles, adverse biological Problems such as metabolism and excretion can be improved to achieve the effect of improving the overall fluorescence intensity, uniform properties, and enhanced fluorescence intensity

Active Publication Date: 2021-02-12
SOUTH CHINA NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current methods for enhancing the surface loading capacity of rare earth fluoride nanomaterials mainly include: 1. By coating a layer of silicon dioxide, or further processing it into a mesoporous structure; Coating a thinner silica layer usually leads to an increase in the diameter of the nanoparticles by at least 10nm, and silica is easy to simultaneously coat two or more rare earth fluoride nanoparticles together, causing A sharp increase in particle size
The increase in particle size is not conducive to the metabolism and excretion in the body when it is used in the body, thus causing stronger biological toxicity.
2. Increase the loading surface by synthesizing a hollow structure; however, there are many steps in this technology, and because of the hollow structure, it is difficult to synthesize small-sized nanoparticles, which is not conducive to the metabolism and excretion of biological extraction
The particle size of rare earth fluoride nanoparticles prepared by this technology varies greatly, and it is difficult to realize the preparation of particles with uniform particle size and properties

Method used

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  • Method for improving surface loading capacity of rare earth fluoride nano material
  • Method for improving surface loading capacity of rare earth fluoride nano material
  • Method for improving surface loading capacity of rare earth fluoride nano material

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Weigh 1mmol lutetium oxide (Lu 2 o 3 ) was placed in a three-necked flask, and 5 mL of deionized water and 5 mL of trifluoroacetic acid (CF 3 COOH), stirred and heated to 98°C, after the rare earth oxide (lutetium oxide) was fully dissolved, the solution was evaporated to dryness (removing water and excess trifluoroacetic acid), and then cooled to room temperature to obtain lutetium trifluoroacetate (Lu( CF 3 COO) 3 ) crystallized for subsequent reactions. The 1mmol particle size is about 30nm hexagonal phase rare earth fluoride nanocrystalline NaYF 4 : Yb, Er2% are dispersed in 10mL cyclohexane, then 2mL of this solution, 10mL oleic acid (OA) and 10mL1-octadecene (ODE) are added in the above-mentioned three-necked flask containing trifluoroacetate, under nitrogen ( N 2 ) flow to 100°C, and stirred for 15 minutes at a constant temperature to remove cyclohexane and moisture in the system; then rapidly raised to 300°C, stopped heating after 2 hours of constant tempe...

Embodiment 2

[0036] Utilize the technical method described in embodiment 1 to obtain reaction product, the rare earth fluoride nanoparticle before and after the reaction is respectively dispersed in cyclohexane, then removes the oleic acid ligand on the nanoparticle surface with pH=1 hydrochloric acid solution (referring to Bogdan , N.; Vetrone, F.; Ozin, G.A.; Capobianco, J.A., Synthesis of Ligand-Free ColloidallyStable Water Dispersible Brightly Luminescent Lanthanide-Doped Upconverting Nanoparticles. Nano Lett. 2011, 11(2), 835-840.). At this time, the nanoparticles enter the water layer from the cyclohexane layer, and then the solution is transferred to a centrifuge tube and centrifuged at a speed of 15,000 rpm for 30 minutes to obtain the rare earth fluoride nanoparticles without ligands on the surface. Rare earth fluoride nanoparticles without oleic acid ligand before and after the reaction were redispersed in ionized water, and then phosphoethanolamine (O-phosphoethanolamine), polyet...

Embodiment 3

[0039] Utilize the technical method described in the embodiment 1 to obtain the reaction product, the rare earth fluoride nanoparticles before and after the reaction are respectively dispersed in cyclohexane, and then the oleic acid ligand on the surface of the nanoparticles is removed with pH=1 hydrochloric acid solution (same as the implementation Example 2), at this time, the nanoparticles enter the water layer from the cyclohexane layer, and then the solution is transferred to a centrifuge tube and centrifuged at a speed of 15,000 rpm for 30 minutes to obtain rare earth fluoride nanoparticles without ligands on the surface. Then take the same mass concentration of rare earth fluoride nanomaterials without ligands on the surface (rare earth fluoride nanoparticles before and after the reaction after deoleic acid treatment) and Rose Bengal (Rose Bengal, RB) organic dyes to react (refer to Muhr, V.; Würth, C.; Kraft, M.; Buchner, M.; Baeumner, A.J.; Resonance Energy Transfer ...

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Abstract

The invention discloses a method for improving the surface loading capacity of a rare earth fluoride nano material. According to the method, trifluoroacetic acid is used for modifying rare earth oxideto prepare rare earth trifluoroacetate, then the rare earth trifluoroacetate is used as a reaction reagent, oleic acid and 1-octadecene are added, the content of trivalent rare earth cations on the surfaces of the hexagonal phase rare earth fluoride nano particles is remarkably increased under the high-temperature reaction condition, so that the loading capacity of the hexagonal phase rare earthfluoride nano particles is enhanced. According to the method, the surface loading capacity of existing hexagonal phase rare earth fluoride nanocrystals is successfully improved by five times, the method is simple and easy to implement and good in repeatability, and the obtained target product is uniform in character.

Description

technical field [0001] The invention belongs to the technical field of inorganic up-conversion materials, and in particular relates to a method for improving the surface loading capacity of rare earth fluoride nanomaterials. Background technique [0002] In recent years, nano-fluorescent probes based on near-infrared excited rare earth upconversion and near-infrared second region (NIR-II) emission have shown important application value in the field of biomedicine. Among them, rare earth fluoride has the advantages of low phonon energy, high luminous efficiency, and good chemical stability, so it is considered to be the preferred host material for rare earth-doped nanofluorescent probes. In particular, rare earth fluoride upconversion nanomaterials have been widely discussed for applications in biomedical imaging, biosensing and detection, drug delivery, and photodynamic therapy. The realization of the above applications benefits from the excellent chemical coordination abil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85C09K11/02B82Y20/00B82Y40/00
CPCC09K11/7773C09K11/025B82Y20/00B82Y40/00
Inventor 魏嵬王梅凤
Owner SOUTH CHINA NORMAL UNIVERSITY
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