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Conductive nerve repair system filled with double drug-loaded nanofibers and preparation method of conductive nerve repair system

A nanofiber, nerve repair technology, applied in pharmaceutical formulations, fibrous chemical characteristics, drug delivery, etc., can solve problems such as limited application and inability to degrade, and achieve the effect of reducing dosage, facilitating adhesion and growth, and helping repair

Active Publication Date: 2021-02-26
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polypyrrole cannot be degraded in the human body, which limits its application in tissue engineering

Method used

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  • Conductive nerve repair system filled with double drug-loaded nanofibers and preparation method of conductive nerve repair system
  • Conductive nerve repair system filled with double drug-loaded nanofibers and preparation method of conductive nerve repair system
  • Conductive nerve repair system filled with double drug-loaded nanofibers and preparation method of conductive nerve repair system

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0042] Such as figure 1 As shown, the present invention provides a kind of preparation method of filling double drug-loaded nanofiber conductive nerve repair system, comprising the following steps:

[0043] 1) Preparation of PPy nanospheres

[0044] Weigh 2.49g of sodium dodecyl sulfate (SDS) and dissolve it in 140mL of deionized water, stir for 30min, then add 2mL of pyrrole (Py) monomer that has been distilled under reduced pressure twice into the SDS solution, stir for 1h, and weigh 8.58 g FeCl 3 Dissolve in 40mL deionized water and stir for 30min. FeCl 3 The solution was added to the SDS solution, reacted at a constant temperature of 10°C for 10h, filtered out the solid product, washed with deionized water, and dried in a vacuum oven at 60°C for 24h to obtain black powder polypyrrole (PPy) nanospheres.

[0045] 2) Preparation of PPy / PLA nerve guide

[0046] Dissolve 1 g of polylactic acid (PLA) with a molecular weight of 150,000 in 10 mL of dichloromethane, stir for 1...

Embodiment 2

[0058] This example is basically the same as Example 1, except that the amount of the soft templating agent SDS in step 1) is changed from 2.49g to 1.85g.

Embodiment 3

[0060] This example is basically the same as Example 1, except that the amount of PPy nanospheres added in step 2) is 0.03 g.

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Abstract

The invention discloses a conductive nerve repair system filled with double drug-loaded nanofibers and a preparation method of the conductive nerve repair system. The conductive nerve repair system comprises double drug-loaded coaxial nanofibers and a hollow polypyrrole / polylactic acid nerve conduit, wherein the polypyrrole / polylactic acid nerve conduit is filled with the double drug-loaded coaxial nanofibers; in the polypyrrole / polylactic acid nerve conduit, polypyrrole nanospheres are uniformly dispersed in polylactic acid; and in each double drug-loaded coaxial nanofiber, a polylactic acid / vascular endothelial growth factor is used as a shell layer, and chitosan / paeoniflorin is used as a core layer. The preparation method comprises the following steps: preparing a polypyrrole / polylacticacid film, and curling the film into a tube to obtain the polypyrrole / polylactic acid nerve conduit; and then obtaining double drug-loaded coaxial nanofibers with a coaxial electrostatic spinning technology, and filling the nerve conduit with the double drug-loaded coaxial nanofibers. The preparation method is simple and high in operability, and the obtained conductive nerve repair system has excellent biocompatibility, mechanical property, degradation property and conductivity and is wide in application prospect.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a conductive nerve repair system filled with double drug-loaded nanofibers and a preparation method thereof. Background technique [0002] Peripheral nerves are distributed on the surface of the whole body of the human body and are easily injured. Peripheral nerve injury (Peripheral Nerve Injury, PNI) generally does not threaten the patient's life safety, but if appropriate treatment measures are not taken in time, neuroma or scar tissue will form at the distal end of the injured nerve, which will hinder nerve regeneration, lead to interruption of nerve channels, and cause Various harmful consequences, such as sensory loss, chronic pain, disability, deformity, etc., seriously affect the normal life and physical and mental health of patients. The regenerative ability of injured peripheral nerves is limited, especially when the defect length is greater than 5mm, the a...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/20A61L27/50A61L27/54A61L27/58D01F8/14D01F8/18D01F1/10
CPCA61L27/18A61L27/20A61L27/50A61L27/54A61L27/58D01F8/14D01F8/18D01F1/10A61L2400/12A61L2430/32A61L2300/414A61L2300/216A61L2300/602C08L79/04C08L67/04C08L5/08
Inventor 徐海星闫秀美许沛虎杨海霞许润天李政吕忆菲黄志军
Owner WUHAN UNIV OF TECH