Drug-loaded medical device and preparation method thereof

A medical device and drug-loading technology, which is applied in the field of drug-loaded medical devices and its preparation, can solve problems such as difficult preparation of macrolide crystals, poor drug transfer effect, weak interaction force, etc., to improve adhesion performance , extend the concentration, improve the effect of transfer speed
CN112546414BActive Publication Date: 2021-06-08SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
Publication Date
2021-06-08

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Abstract

The present invention relates to the field of medicine technology, in particular to a drug-loaded medical device, comprising a medical device body and at least one drug coating, the drug coating is attached to at least one side of the surface of the medical device body, and The main components of the drug coating include macrolide drugs, the drug coating includes long columnar crystals with more than three ribs, and / or the drug coating includes long columnar crystals with more than three ribs Crystal clusters formed by crystals, the aspect ratio of the long columnar crystals is (1-40):1. The drug-loaded medical device can effectively improve the transfer of the drug to the blood vessel wall and prolong the concentration of the drug in the tissue.
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Description

technical field

[0001] The invention relates to the technical field of medical devices, in particular to a drug-loaded medical device and a preparation method thereof. Background technique

[0002] In recent years, a variety of interventional or implantable medical devices containing drug coatings have been developed for various mechanisms of intravascular restenosis. Drug-coated balloons and drug-eluting stents are essentially derived from the concept of a catheter-based local drug delivery device, which inhibits intimal hyperplasia by carrying drugs, but the way of carrying the drug and the local drug action time are different. The concept of "intervention without implantation" of drug-coated balloons has attracted more and more attention. A number of clinical trials have confirmed that it has satisfactory efficacy and safety in various coronary artery stenosis lesions, small vessel lesions, and bifurcation lesions. The surface of the drug-coated balloon is uniformly coa...

Claims

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