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Preparation method of polydopamine/polylactic acid/nano-copper composite fiber membrane with photo-thermal/copper synergistic antibacterial function

A technology of composite fibrous membrane and polylactic acid fiber, which can be applied in fiber type, fiber treatment, biochemical fiber treatment, etc., can solve the problems of increasing surgical risk and developing drug resistance, and achieves the promotion of osteogenesis and angiogenesis, and promotes bone tissue repair. , rapid and long-lasting anti-bacterial effect

Pending Publication Date: 2021-03-30
XINJIANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current common treatment methods for bone infection are debridement and systemic antibiotic therapy, but long-term or excessive use of antibiotics will increase the risk of surgery and produce drug resistance

Method used

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  • Preparation method of polydopamine/polylactic acid/nano-copper composite fiber membrane with photo-thermal/copper synergistic antibacterial function
  • Preparation method of polydopamine/polylactic acid/nano-copper composite fiber membrane with photo-thermal/copper synergistic antibacterial function
  • Preparation method of polydopamine/polylactic acid/nano-copper composite fiber membrane with photo-thermal/copper synergistic antibacterial function

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Experimental program
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Effect test

Embodiment 1

[0033] The invention provides a method for preparing a polydopamine / polylactic acid / nano-copper composite fiber membrane with photothermal / copper synergistic antibacterial function, comprising the following steps:

[0034] (1) Dissolve 1.44 g of polylactic acid in 9 mL of trifluoroethanol, and use mechanical stirring at a speed of 1300r / min for 16 h to completely dissolve it to obtain a uniform electrospinning solution of polylactic acid;

[0035] (2) Electrospinning was carried out with the polylactic acid electrospinning solution obtained in step (1) as the raw material. The parameters were high-voltage electrostatic field voltage 15kv, spinning receiving distance 13 cm, and syringe advancing speed 3 mL / h. Polylactic acid fiber membrane on the surface of the foil collector;

[0036] (3) The polylactic acid fiber membrane obtained in step (2) was vacuum-dried at 70°C for 72 h to completely remove the residual solvent, and then the obtained fiber membrane was cut into 2 cm×2 c...

Embodiment 2

[0043] The invention provides a method for preparing a polydopamine / polylactic acid / nano-copper composite fiber membrane with photothermal / copper synergistic antibacterial function, comprising the following steps:

[0044] (1) Dissolve 1.81 g of polylactic acid in 15 mL of dimethyl sulfoxide, and use mechanical stirring at a speed of 1000r / min for 20 h to completely dissolve it to obtain a uniform electrospinning solution of polylactic acid;

[0045] (2) Electrospinning was carried out using the polylactic acid electrospinning solution obtained in step (1) as a raw material. The parameters were high-voltage electrostatic field voltage 12kv, spinning receiving distance 15 cm, and syringe advancing speed 2 mL / h. Polylactic acid fiber membrane on the surface of the foil collector;

[0046] (3) The polylactic acid fiber membrane obtained in step (2) was vacuum-dried at 80°C for 96 h to completely remove the residual solvent, and then the obtained fiber membrane was cut into 4 cm×4...

Embodiment 3

[0052] The invention provides a method for preparing a polydopamine / polylactic acid / nano-copper composite fiber membrane with photothermal / copper synergistic antibacterial function, comprising the following steps:

[0053] (1) Dissolve 6.56 g of polylactic acid in 36 mL of an equal proportion mixed solution of hexafluoroisopropanol and chloroform, and use a mechanical stirrer at a speed of 1500r / min for 12 h to completely dissolve it to obtain a uniform electrospun polylactic acid silk solution;

[0054] (2) Electrospinning was carried out with the polylactic acid electrospinning solution obtained in step (1) as raw material. The parameters were high-voltage electrostatic field voltage 18kv, spinning receiving distance 14 cm, and syringe advancing speed 4 mL / h. Polylactic acid fiber membrane on the surface of the foil collector;

[0055] (3) The polylactic acid fiber membrane obtained in step (2) was vacuum-dried at 80°C for 96 h to completely remove the residual solvent, and...

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Abstract

The invention discloses a preparation method of a polydopamine / polylactic acid / nano-copper composite fiber membrane with a photo-thermal / copper synergistic antibacterial function. According to the method, the respective characteristics of good biocompatibility and degradability of polylactic acid, chelation and reducibility of polydopamine to metal ions, and broad-spectrum antibacterial property,bacterial drug resistance, responsiveness to near-infrared light and the like of copper nanoparticles, and the unique advantages of an electrostatic spinning technology in the aspect of constructing abionic fiber structure with controllable morphology are integrated, the prepared composite fiber membrane can simulate a natural extracellular matrix in vivo, accelerate angiogenesis and stimulate bone formation; and through photo-thermal / nano-copper synergistic bacterial infection resistance, bone tissue repair is promoted, and the bone repair material can be widely applied to the fields of boneinjury repair and bone defect treatment.

Description

technical field [0001] The invention relates to a preparation method of a medical polymer composite material, in particular to a preparation method of a polydopamine / polylactic acid / nano-copper composite fiber film with photothermal / copper synergistic antibacterial functions. Background technique [0002] Millions of patients around the world suffer from bone diseases or bone defects. The research and development of bone repair materials is an urgent problem to be solved. The ideal artificial bone synthetic biomaterial should have good biocompatibility, bioactivity, osteoinductivity and antibacterial sex. [0003] Polylactic acid (PLLA) has been approved for clinical application by the US Food and Drug Administration (FDA) due to its good biocompatibility, biodegradability, and non-toxicity. Bone tissue regeneration, drug delivery, soft tissue repair, etc. are currently one of the research hotspots of artificial bone biomedical materials, but the lack of osteoinductive and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M11/83D06M15/37D04H1/728D04H1/435D01D5/00A61L27/18A61L27/04A61L27/54A61L27/58D06M101/32
CPCD06M11/83D06M15/37D06M16/00A61L27/18A61L27/047A61L27/54A61L27/58D04H1/728D04H1/435D01D5/0092D01D5/0076D01D5/003D06M2101/32A61L2300/102A61L2300/404A61L2300/412A61L2400/12A61L2430/02C08L67/04C08L79/04
Inventor 王英波刘菲菲高雅粟智
Owner XINJIANG NORMAL UNIVERSITY
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