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Antibacterial hemostatic membrane as well as preparation method and application thereof

A technology of hemostatic film and thin film, applied in pharmaceutical formulation, pharmaceutical science, drug delivery, etc., can solve the problems of susceptibility to infection, loss of microsphere material, and difficulty of hemostatic microspheres to deal with large-area wounds, etc., and achieves short hemostasis time and rapid degradation. Speed, low-value effects

Inactive Publication Date: 2021-04-02
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chinese patent CN 110755672 A discloses an antibacterial hemostatic sponge and its preparation method. Its main raw materials are polylactic acid, oxidized cellulose and chitosan, which solves the problems of large wound bleeding and easy infection
However, hemostatic microspheres are difficult to deal with large-area trauma, and blood flow is likely to cause loss of microsphere materials, reduce the contact between hemostatic microspheres and wound bleeding, and affect the hemostatic performance of hemostatic microspheres. Other auxiliary materials need to be fixed to ensure more good hemostatic effect

Method used

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  • Antibacterial hemostatic membrane as well as preparation method and application thereof
  • Antibacterial hemostatic membrane as well as preparation method and application thereof
  • Antibacterial hemostatic membrane as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Preparation of matrix solution: Add 6 g of sodium alginate, 3 g of carboxymethyl chitosan, 0.15 g of collagen and 45 mL of glycerin to 555 ml of water for dissolving, and let stand at room temperature for 12 hours to remove bubbles inside the solution. Make 3 parts matrix solution.

[0038] 2. Cross-linking: Prepare 60 mL of calcium chloride solution with a mass concentration of 2%, and slowly pour the prepared matrix solution into an aluminum alloy container, spray the calcium chloride aqueous solution evenly with a watering can, carry out cross-linking reaction, and let stand After 15 min, transfer to a 37 °C incubator and let it stand for 48 h.

[0039] 3. Storage: Take a plastic template, cut it into several square films with a size of 10 cm×10 cm and a thickness of 1-2 mm, pack it in aluminum paper, weigh and seal it, and store it in a refrigerator at 4 °C.

Embodiment 2

[0041] 1. Preparation of matrix solution: Add 8 g sodium alginate, 4 g carboxymethyl chitosan, 0.2 g collagen, 0.12 g berberine hydrochloride and 60 mL glycerin to 740 ml water for dissolution, and let stand at room temperature for 12 h. Used to remove air bubbles inside the solution to make 4 parts of matrix solution.

[0042] 2. Cross-linking: Prepare 80 mL of calcium chloride solution with a mass concentration of 2%, and slowly pour the prepared matrix solution into an aluminum alloy container, spray the calcium chloride aqueous solution evenly with a watering can, carry out cross-linking reaction, and let stand After 15 min, transfer to a 37 °C incubator and let it stand for 48 h.

[0043] 3. Storage: Take a plastic template, cut it into several square films with a size of 10 cm×10 cm and a thickness of 1-2 mm, pack it in aluminum paper, weigh and seal it, and store it in a refrigerator at 4 °C.

Embodiment 3

[0045] 1. Preparation of matrix solution: 8 g sodium alginate, 4 g carboxymethyl chitosan, 0.2 g collagen, 0.36 g berberine hydrochloride and 60 mL glycerin were dissolved in 740 ml water respectively, and allowed to stand at room temperature for 12 h. Used to remove air bubbles inside the solution to make 4 parts of matrix solution.

[0046] 2. Cross-linking: Prepare 80 mL of calcium chloride solution with a mass concentration of 2%, and slowly pour the prepared matrix solution into an aluminum alloy container, spray the calcium chloride aqueous solution evenly with a watering can, carry out cross-linking reaction, and let stand After 15 min, transfer to a 37 °C incubator and let it stand for 48 h.

[0047] 3. Storage: Take a plastic template, cut it into several square films with a size of 10 cm×10 cm and a thickness of 1-2 mm, pack it in aluminum paper, weigh and seal it, and store it in a refrigerator at 4 °C.

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Abstract

The invention relates to an antibacterial hemostatic membrane as well as preparation and application thereof. According to the antibacterial hemostatic membrane, sodium alginate, carboxymethyl chitosan, collagen and berberine hydrochloride are taken as raw materials, and the biological composite hemostatic membrane is prepared by adding a humectant and adding calcium chloride droplets in an atomizing manner to serve as a cross-linking agent. The hemostatic membrane can quickly stop bleeding of local large-area wounds and prevent bacterial infection of the wounds; and the hemostatic membrane isgood in biocompatibility, free of hemolysis, rapid and efficient in degradation and free of influence on wound healing.

Description

technical field [0001] The invention relates to an antibacterial hemostatic membrane containing berberine hydrochloride, a preparation method and related applications thereof. [0002] Background of the invention [0003] The skin is the body's first barrier against external stimuli and damage. There are always people with skin damage due to mechanical damage, burns, surgery and war. These wounds are often accompanied by bleeding and bacterial infection. The loss of blood can lead to a series of systemic reactions in the human body, even shock and death. Nearly half of trauma victims are caused by uncontrollable bleeding. Wound infection is a pathological reaction in which pathogenic microorganisms invade the human body through the wound, grow and reproduce in the body, and cause local changes in the human body or systemic poisoning. Therefore, the key to preventing bleeding death lies in safe and effective rapid hemostasis. [0004] With the development of the times, mater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/009A61L26/0052A61L2300/404A61L2300/204A61L2300/604A61L2400/04C08L5/04C08L5/08
Inventor 叶飞金甲王磊徐明张文平舒建洪吕正兵
Owner ZHEJIANG SCI-TECH UNIV
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