Thermoseed containing self-temperature-control magnetic nanowire for magnetic thermal therapy and manufacturing method thereof

A magnetic nanometer and manufacturing method technology, applied in X-ray/γ-ray/particle irradiation therapy, radiotherapy, treatment, etc., can solve the problems of inability to realize automatic temperature control, low heat production efficiency of metal or alloy magnetic heat seeds, etc., to achieve Easy to promote, good biocompatibility and corrosion resistance, good performance consistency

Active Publication Date: 2021-04-02
HARBIN ENG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem that the current metal or alloy magnetic thermal seeds have low heat production efficiency and cannot realize automatic temperature control, the present invention provides a thermal seed for magnetic hyperthermia containing self-temperature-controlling magnetic nanowires and a manufacturing method thereof

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  • Thermoseed containing self-temperature-control magnetic nanowire for magnetic thermal therapy and manufacturing method thereof
  • Thermoseed containing self-temperature-control magnetic nanowire for magnetic thermal therapy and manufacturing method thereof

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Embodiment 1

[0032] This embodiment provides a heat seed for magnetic hyperthermia containing self-temperature-controlling magnetic nanowires, including a titanium alloy shell 3, a surface modification layer 4 coated on the outside of the shell, and self-temperature-controlling magnetic nanowires sealed in the shell. Wire suspension; the self-temperature-controlling magnetic nanowires are zinc-cobalt-chromium ferrite magnetic nanowires, and their Curie temperature is 42-45°C.

Embodiment 2

[0034] This embodiment provides a heat seed for magnetic hyperthermia containing self-temperature-controlling magnetic nanowires, including a titanium alloy shell 3, a surface modification layer 4 coated on the outside of the shell, and self-temperature-controlling magnetic nanowires sealed in the shell. Wire suspension; the Curie temperature point of the self-temperature-controlling magnetic nanowire is 42-45°C.

[0035] In this embodiment, the titanium alloy casing 3 is an hourglass-shaped rotating body with a length of 3 to 15 mm. The diameters of the cross sections at both ends of the casing are 0.7 to 2.5 mm. The diameter ratio of the section is 1:0.5~0.9, and the shell thickness is 0.05mm. The material used for the titanium alloy shell is the existing medical titanium alloy with the grades: TA1ELI, TA1, TA2, TA3, TA4, TC4, TC4ELI or TC20.

[0036] Compared with the traditional cylindrical thermal seeds, the thermal seeds provided in this embodiment are hourglass-shaped ro...

Embodiment 3

[0038] This embodiment provides a heat seed for magnetic hyperthermia containing self-temperature-controlling magnetic nanowires, including a titanium alloy shell 3, a surface modification layer 4 coated on the outside of the shell, and self-temperature-controlling magnetic nanowires sealed in the shell. Wire suspension; the Curie temperature point of the self-temperature-controlling magnetic nanowire is 42-45°C. The titanium alloy shell 3 is an hourglass-shaped rotating body with a length of 3 to 15 mm. The diameters of the cross sections at both ends of the shell are 0.7 to 2.5 mm. The ratio of the diameter of the cross sections at both ends of the shell to the diameter of the smallest cross section in the center It is 1:0.5~0.9, and the shell thickness is 0.06mm.

[0039] In this embodiment, the surface modification layer coated on the outer surface of the titanium alloy shell is a hydroxyapatite coating or a silicon dioxide coating, with a thickness of 0.5-25 μm. Both hyd...

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Abstract

The invention relates to a thermoseed containing a self-temperature-control magnetic nanowire for magnetic thermal therapy and a manufacturing method thereof, and belongs to the technical field of tumor magnetic induction thermal therapy. In order to solve the problems that an existing metal or alloy magnetic thermoseed is low in heat production efficiency and cannot achieve automatic temperaturecontrol, the thermoseed containing the self-temperature-control magnetic nanowire for magnetic thermal therapy comprises a sand clock type rotating body titanium alloy shell, a surface modification layer coating the shell and a self-temperature-control magnetic nanowire turbid liquid sealed in the shell; the self-temperature-control magnetic nanowire is a zinc-cobalt-chromium ferrite magnetic nanowire, and the Curie point temperature of the self-temperature-control magnetic nanowire is 42-45 DEG C. According to the thermoseed containing the self-temperature-control magnetic nanowire for magnetic thermal therapy and the manufacturing method thereof, automatic temperature control of the thermoseed between 42 DEG C and 45 DEG C is achieved on the basis of the self-temperature-control magneticnanowire, the heat production rate of the thermoseed is high, heat distribution is uniform, good biocompatibility is achieved, the thermoseed can be accurately positioned in tumor tissue, the movingand wandering phenomenon is not prone to occurring, and the thermoseed can be used for targeted therapy of tumors when used in cooperation with a magnetic thermal therapy instrument.

Description

technical field [0001] The invention belongs to the technical field of tumor magnetic induction hyperthermia, and in particular relates to a thermoseed for magnetic hyperthermia containing self-temperature-controlling magnetic nanowires and a manufacturing method thereof. Background technique [0002] The methods of treating tumors at home and abroad mainly include surgery, radiation therapy, chemical drug therapy, biological therapy and hyperthermia. Tumor hyperthermia technology has developed rapidly, and compared with chemotherapy and radiotherapy, it has fewer side effects and can be used repeatedly. It is called "green therapy" for tumor treatment. Medical research has proved that increasing the temperature can cause protein denaturation, damage tumor cell membranes and enzymes, inhibit DNA, RNA and protein synthesis, inhibit tumor cell proliferation, and directly lead to tumor cell apoptosis. [0003] Magnetic induction therapy technology is an advanced technology wit...

Claims

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Application Information

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IPC IPC(8): A61N5/10C23C4/134C23C4/04C23C18/42C23C28/00
CPCA61N5/1002A61N5/1007C23C4/134C23C4/04C23C18/42C23C28/322C23C28/34A61N2005/1024
Inventor 张洪泉张凯
Owner HARBIN ENG UNIV
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