Heterocyclic substituted 1, 3, 4-oxadiazole hydrazide compound and preparation method and application thereof

A technology of oxadiazole hydrazide and compounds, applied in the field of medicinal chemistry, can solve the problems of farmers' economic losses, quality reduction, and crop yield decline
CN112608307APending Publication Date: 2021-04-06GUIZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUIZHOU UNIV
Publication Date
2021-04-06

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Abstract

The invention relates to heterocyclic substituted 1, 3, 4-oxadiazole hydrazide compounds and a preparation method and application thereof. The compound has a structure shown as a general formula (I). The compound has a relatively good inhibition effect on pathogenic fungi and bacteria; and the compound has good inhibition effects onfusarium graminearum, potato late blight bacteria, blueberry root rot bacteria, pepper fusarium wilt, sclerotinia sclerotiorum, colletotrichum gloeosporioides, botryosphaeria dothidea, rhizoctonia solani, xanthomonas oryzae pv., ralstonia solannacearum, Xanthomonas citri, kiwi canker bacteria, Xanthomonas oryzae cucumber, Xanthomonas oryza konjak, Botryosphaeria dothidea, tomato canker pathogens, apple canker pathogens and the like.
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Description

technical field

[0001] The invention relates to the technical field of medicinal chemistry, in particular to a 1,3,4-oxadiazole hydrazide compound containing an N heterocyclic group or a 1,3,4-oxadiazole hydrazide group substitution and a preparation method thereof and application. Background technique

[0002] In recent years, plant fungi and bacteria have seriously affected the yield and quality of crops around the world. Plant fungal diseases directly cause crop yield and quality reduction, and bring huge economic losses to farmers. For example, Gibberellazeae. Retch is a filamentous ascomycete, which is caused by a variety of Fusarium infection and occurs on wheat. The pathogen can cause wheat seedling rot, stalk rot, stem rot and ear rot, and it brings at least 10-20% yield reduction to wheat-growing countries every year. In addition, rice bacterial blight (Xanthomonas oryzaepv.Oryzae) is a rod-shaped Gram-negative bacterium, which can cause the leaves of rice to with...

Claims

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