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Mesoporous bioactive glass/chitosan composite hemostatic sponge and preparation method thereof

A technology of bioactive glass and hemostatic sponge, which is applied in the field of medical devices, achieves the effect of simple method, broad application prospect and wide source

Active Publication Date: 2021-04-09
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to address the structural defects of existing sponges, to provide a bioactive glass / chitosan composite sponge with a hierarchical pore structure and a preparation method thereof, and to obtain a composite sponge with good hemostatic properties. sponge

Method used

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  • Mesoporous bioactive glass/chitosan composite hemostatic sponge and preparation method thereof
  • Mesoporous bioactive glass/chitosan composite hemostatic sponge and preparation method thereof
  • Mesoporous bioactive glass/chitosan composite hemostatic sponge and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0046] A mesoporous bioactive glass / chitosan composite hemostatic sponge and a preparation method thereof, the preparation method of which is as follows:

[0047] (1) Preparation steps of mesoporous bioactive glass powder:

[0048] 1) Dissolve 0.6g of urea and 2g of cetylpyridinium bromide (CPB) in 150ml of deionized water, and stir evenly;

[0049] 2) After adding 42ml of cyclohexane, add 0.84g of isopropanol as a surfactant, and stir vigorously to form a uniform emulsion;

[0050] 3) Use a syringe pump to add 4.8g tetraethyl orthosilicate (TEOS) dropwise at a rate of 2ml / min. After reacting at room temperature for 30 minutes, add 0.6g triethyl phosphate (TEP) dropwise, and react for 30 minutes and then heat up to Continue to react for 12 hours at 70°C under the conditions of oil bath and condensing reflux, then add 3.112g of calcium nitrate tetrahydrate (CN), continue to react for 4 hours, cool to room temperature, and age for 18 hours;

[0051] 4) Centrifuge at 10,000r / mi...

Embodiment 2

[0058] A mesoporous bioactive glass / chitosan composite hemostatic sponge and a preparation method thereof, the preparation method of which is as follows:

[0059] (1) Preparation steps of mesoporous bioactive glass powder:

[0060] 1) Dissolve 1.6g of urea and 8g of cetylpyridinium bromide (CPB) in 192ml of deionized water, and stir well;

[0061] 2) After adding 128ml of cyclohexane, add 2g of isopropanol as a surfactant, and stir vigorously to form a uniform emulsion;

[0062] 3) Use a syringe pump to add 14.5g tetraethyl orthosilicate (TEOS) dropwise at a speed of 2ml / min. After reacting at room temperature for 30 minutes, add 0.483g triethyl phosphate (TEP) dropwise, and heat up to Continue to react for 12 hours at 70°C under the conditions of oil bath and condensing reflux, then add 2.507g of calcium nitrate tetrahydrate (CN), continue to react for 4 hours, cool to room temperature, and age for 24 hours;

[0063] 4) Centrifuge at 10,000r / min for 20min, wash with acetone...

Embodiment 3

[0070] A mesoporous bioactive glass / chitosan composite hemostatic sponge and a preparation method thereof, the preparation method of which is as follows:

[0071] (1) Preparation steps of mesoporous bioactive glass powder:

[0072] 1) Dissolve 1.333g of urea and 8g of cetylpyridinium bromide (CPB) in 200ml of deionized water, and stir evenly;

[0073] 2) After adding 120ml of cyclohexane, add 1.5g of isopropanol as a surfactant, and stir vigorously to form a uniform emulsion;

[0074] 3) Use a syringe pump to add 13.33g tetraethyl orthosilicate (TEOS) dropwise at a rate of 2ml / min. After reacting at room temperature for 30 minutes, add 0.256g triethyl phosphate (TEP) dropwise, and react for 60 minutes and then heat up to Continue to react for 12 hours at 75°C under the conditions of oil bath and condensing reflux, then add 1.329g of calcium nitrate tetrahydrate (CN), continue to react for 5 hours, cool to room temperature, and age for 24 hours;

[0075] 4) Centrifuge at 10,0...

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Abstract

The invention discloses mesoporous bioactive glass / chitosan composite hemostatic sponge and a preparation method thereof. The method comprises the following steps of preparing mesoporous bioactive glass by using a bicontinuous microemulsion technology in combination with a sol-gel template method, blending a chitosan solution, a polyvinyl alcohol solution and the mesoporous bioactive glass, performing uniform dispersing, adding a cross-linking agent for a reaction, pouring a reaction product into a mold, performing pre-freezing and molding, and performing freeze-drying to obtain the mesoporous bioactive glass / chitosan composite hemostatic sponge. The composite sponge is simple in preparation process; red blood cells are agglutinated through the combination of polycations of a chitosan material and anions on the surface of a blood red cell membrane, platelet aggregation is activated, and thrombin is activated; the mechanical strength, porosity and water absorption rate of the sponge are improved due to the addition of the mesoporous bioactive glass; when being in contact with a wound, the sponge can rapidly absorb liquid, so that the aggregation of platelets and red blood cells is accelerated, blood clots are rapidly formed and accumulated in a sponge network structure with hierarchical pores, and finally the hemostatic effect is achieved; and the sponge has a good application prospect in the field of hemostatic materials.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a mesoporous bioactive glass / chitosan composite hemostatic sponge and a preparation method thereof. Background technique [0002] At present, the research on hemostatic materials at home and abroad mainly focuses on how to apply them to the local hemostasis of the human body, and it must not only be efficient and rapid, but also have certain biological safety, including degradability in the body, and no pain when removing the hemostatic material. Secondary bleeding, no toxic effects on tissues and organisms, etc. In addition, it also needs to have certain characteristics, including low cost, plasticity, portability, simple method of use, stable performance, and does not affect tissue healing. [0003] The hemostatic materials are mainly divided into two categories: biological type and chemical type. Biological hemostatic materials mainly include fibrin glue and collagen, etc., bu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/02A61L24/08A61L24/06A61L24/00
CPCA61L24/0036A61L24/02A61L24/08A61L24/06A61L24/001A61L2400/04C08L5/08C08L29/04
Inventor 陈晓峰戴翔王刚
Owner SOUTH CHINA UNIV OF TECH
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