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A kind of oral flora polymorphism regulator

A polymorphism and regulator technology, applied in antifungal agents, antibacterial agents, plant/algae/fungus/moss components, etc., can solve the relative balance, poor taste and safety issues affecting oral microbial diversity Can not be ignored and other issues, to achieve the effect of excellent maintenance of oral ecological diversity, sweet and refreshing taste, safe and non-toxic process

Active Publication Date: 2022-04-19
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the antibacterial components of the mouthwash are not selective, they will kill the beneficial bacteria in the oral cavity while inhibiting the pathogenic bacteria, affecting the diversity of oral microorganisms and the relative balance of the flora, which will have an adverse effect on oral health. Even become the cause of oral problems or cause problems to aggravate
[0004] Studies have shown that most of the oral gargles currently on the market focus on the killing of pathogenic bacteria, while ignoring the impact on probiotics in the oral cavity. Long-term repeated use may lead to the disorder of oral flora
In addition, western medicine mouthwashes and sprays, which are widely used in the market and clinically, have strong antibacterial and bactericidal effects, large side effects, easy to produce drug resistance, and poor taste
Exogenous supplementation of probiotics also has certain risks, and its potential safety issues cannot be ignored. It has been reported that the abuse of probiotic supplements may also cause infection, horizontal transfer of drug resistance, gastrointestinal ischemia, metabolic Disorders, allergic reactions, immune dysfunction and other adverse consequences

Method used

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  • A kind of oral flora polymorphism regulator
  • A kind of oral flora polymorphism regulator
  • A kind of oral flora polymorphism regulator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1: Screening of natural plant extracts

[0073] 1. Instruments and materials

[0074] 1.1 Instrument

[0075] HCB-900V vertical laminar flow clean bench (Qingdao Haier Special Electric Co., Ltd.); SW-CJ-JF ultra-clean bench (Suzhou purification plant); HPX-9052MBE electric heating constant temperature incubator (Shanghai Boxun Industrial Co., Ltd. Medical Equipment Factory); BSD-TX345 desktop shaker (Shanghai Boxun Industrial Co., Ltd. Medical Equipment Factory); infinite M200 PRO microplate reader (US TECAN company); EYELA N-1210B rotary evaporator (Shanghai Ailon Instrument Co., Ltd.); EYELA-1000S Circulating water vacuum pump (Tokyo Physical and Chemical Instrument Co., Ltd.); FA124 electronic balance (Tianjin Yinuo Scientific Instrument Co., Ltd.); LS-B 50L vertical pressure steam sterilizer (Shanghai Medical Nuclear Instrument Factory).

[0076] 1.2 Materials

[0077] Streptococcus salivarius (S.salivarius, ATCC13419) was purchased from Guangdong Micr...

Embodiment 2

[0098] Embodiment 2. extract extraction process and proportioning research

[0099] 1. Instruments and materials

[0100] 1.1 Instrument

[0101] HCB-900V vertical laminar flow clean bench (Qingdao Haier Special Electric Co., Ltd.); SW-CJ-JF ultra-clean bench (Suzhou purification plant); HPX-9052MBE electric heating constant temperature incubator (Shanghai Boxun Industrial Co., Ltd. Medical Equipment Factory); BSD-TX345 desktop shaker (Shanghai Boxun Industrial Co., Ltd. Medical Equipment Factory); infinite M200 PRO microplate reader (US TECAN company); FA124 electronic balance (Tianjin Yinuo Scientific Instrument Co., Ltd.); LS-B 50L vertical Pressure steam sterilizer (Shanghai Medical Nuclear Instrument Factory). Agilent1260 high performance liquid chromatography, Agilent20RBAX Eclipse Plus chromatographic column (250mm×4.6mm, 5μm), YP1001 electronic balance (Shanghai Qinghai Instrument Co., Ltd.), AX205 1 / 100,000 electronic balance (Switzerland METTLER TOLEDO company), Mi...

Embodiment 3

[0240] Embodiment 3. preparation active ingredient of the present invention

[0241] Take 15 g of Scutellaria baicalensis coarse powder, add 15 times the amount of purified water, reflux for extraction for 2 hours, centrifuge and filter until clarification, and concentrate the filtrate under reduced pressure at 60°C to a clear paste with a crude drug concentration of about 1g / mL

[0242] Take 15 g of eucommia leaves, add 20 times the amount of purified water, soak and extract at 60°C for 2 hours, centrifuge and filter until clarified, and concentrate the filtrate at 60°C under reduced pressure to a clear paste with a crude drug concentration of about 1 g / mL.

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Abstract

The invention relates to an oral flora polymorphism regulator, in particular to a composition for maintaining oral ecological diversity and regulating flora structure and its application, belonging to the technical fields of pharmaceutical preparations and oral health care products. An oral flora polymorphism regulator, the active ingredient of which is composed of scutellaria baicalensis extract and eucommia ulmoides leaf extract, and the mass ratio of the scutellaria baicalensis extract and eucommia ulmoides leaf extract to the crude drug is 1:16-16:1. The active ingredient of the present invention is a natural plant extract, the quantity of medicinal taste is small, and the safe and non-toxic optimal process is simple and easy. inflammation and mouth ulcers.

Description

technical field [0001] The invention relates to an oral flora polymorphism regulator, in particular to a composition for maintaining oral ecological diversity and regulating flora structure and its application, and belongs to the technical fields of pharmaceutical preparations, oral health care products and daily chemical products. Background technique [0002] The oral cavity is the channel connecting the respiratory tract and digestive tract to the outside world, providing suitable temperature, humidity and nutrient source for the colonization of microorganisms. The diversity of microorganisms in the oral cavity is conducive to maintaining the physiological functions of the oral cavity and resisting the invasion of the body by external adverse factors. Once the microbial flora is out of balance, it can lead to oral diseases such as dental caries, periodontal (gingivitis) and oral ulcers. Studies have shown that the human oral cavity is composed of more than 700 kinds of ba...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539A61P1/02A61P31/04A61P31/10A61K36/46
CPCA61K36/539A61K36/46A61P1/02A61P31/04A61P31/10A61K2236/331A61K2236/333A61K2236/51A61K2300/00
Inventor 王亚静高秀梅赵鑫刘二伟商利娜王雁雯高迪
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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