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Double-sided guided bone repair membrane and preparation method and application thereof

A bone repair, double-sided technology, applied in pharmaceutical formulations, coatings, pharmaceutical sciences, etc., can solve problems such as hindering the development of nanomaterials, and achieve the effects of avoiding immune rejection, inhibiting bacterial growth, and simple preparation process.

Inactive Publication Date: 2021-06-01
CHINA UNIV OF GEOSCIENCES (BEIJING)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, inorganic nanoparticles are often biotoxic, which hinders the development of such nanomaterials in clinical trials

Method used

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  • Double-sided guided bone repair membrane and preparation method and application thereof
  • Double-sided guided bone repair membrane and preparation method and application thereof
  • Double-sided guided bone repair membrane and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A method for preparing a double-sided guided bone repair membrane, comprising the following steps:

[0047] (1) Type I collagen sponge is used as the substrate, and the substrate is subjected to plasma treatment to make the surface hydroxylated, so as to achieve better hydrophilicity, so as to facilitate the subsequent assembly process;

[0048] (2) The acetic acid solution of configuration 1mol / L dissolves chitosan as solvent, prepares the chitosan solution of 1mg / mL, configures the polyacrylic acid solution of 1mg / mL;

[0049] (3) The chitosan solution is dropped onto the surface of the substrate A, and then the droplet is sucked away along the surface of the substrate with a vacuum pump;

[0050] (4) Drop the polyacrylic acid solution onto the A surface of the substrate, and then use a vacuum pump to suck the droplet along the surface of the substrate;

[0051] (5) repeat step (3) and (4) 10 times, then carry out step (3) again, utilize the variation of infrared det...

Embodiment 2

[0064] In this embodiment, the difference from Embodiment 1 is that in step (9), step (7) and step (8) are alternately repeated 10 times; other steps and operations are completely consistent with embodiment 1.

Embodiment 3

[0066] In this embodiment, the difference from Example 1 is: in steps (2) and (6), the concentrations of chitosan solution, polyacrylic acid solution, collagen solution and polyethylene glycol solution of configuration are all 0.5mg / mL ; Other parts are completely consistent with embodiment 1.

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Abstract

The invention belongs to the technical field of layer-by-layer self-assembly and biomineralization, and provides a double-sided guided bone repair membrane and a preparation method and application thereof. I-type collagen sponge serves as a substrate, and an antibacterial coating and a bone repair coating are arranged on the upper surface and the lower surface of the substrate respectively; the antibacterial coating is of a layer structure formed by mutually stacking chitosan layers and polyacrylic acid layers, and the layer, in contact with the substrate, on the layer structure and the surface layer on the other side of the layer structure are the chitosan layers; the bone repair coating comprises a collagen layer and polyethylene glycol layer mutually stacked layer and a calcium phosphate layer; the contact layer of the collagen layer and polyethylene glycol layer interactive stacking layer and the substrate is a collagen layer, and the contact layer of the collagen layer and polyethylene glycol layer interactive stacking layer and the calcium phosphate layer is a polyethylene glycol layer. The shear flow driving force self-assembly technology is adopted, through a layer-by-layer alternate deposition method, by means of weak interaction combination between layers, preparation of different components on the two sides of the substrate is achieved, and the method is simple in process, short in period, suitable for mass production and wide in application prospect.

Description

technical field [0001] The invention generally relates to the technical field of layer-by-layer self-assembly and biomineralization preparation, and specifically relates to a double-sided guided bone repair membrane and its preparation method and application. Background technique [0002] Supramolecular chemistry is developing rapidly and attracting more and more attention from the scientific community. The goal of supramolecular chemistry is to synthesize materials in a non-covalent manner. Non-covalent forces exist everywhere in natural living systems, such as the quaternary structure of proteins and double-stranded DNA in phospholipid bilayer membranes. In particular, supramolecular nanotechnology has shown great potential in the diagnosis and treatment of diseases. Specifically, nanoparticles with tunable and diverse properties can be prepared by supramolecular self-assembly technology, which has great potential in the field of nanomedicine. Today, nanomaterials develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/34A61L27/32A61L27/50A61L27/54
CPCA61L27/24A61L27/32A61L27/34A61L27/50A61L27/54A61L2300/236A61L2300/404A61L2300/412A61L2400/18A61L2420/02A61L2420/06A61L2420/08A61L2430/02C08L5/08C08L33/02C08L89/00C08L71/02
Inventor 张以河安琪马泽群
Owner CHINA UNIV OF GEOSCIENCES (BEIJING)
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