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Bone regeneration multiple bionic scaffold material and preparation method thereof

A scaffold material, a technology for bone regeneration, applied in tissue regeneration, pharmaceutical formulations, pharmaceutical sciences, etc., can solve the problems of adverse effects on initial adhesion, decrease in scaffold pore size and porosity, and rapid exchange of nutrients affecting cell growth, and achieve cell adhesion. Good growth, good osteogenic activity and good controllability

Active Publication Date: 2021-06-01
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a significant increase in the number of intercalations between sheets will inevitably lead to a significant decrease in the pore size and porosity of the scaffold, which will seriously affect the growth of cells towards the interior of the scaffold and the rapid exchange of nutrients.
In addition, the surface of the scaffold material prepared by this scheme is relatively smooth, and the initial adhesion of cells on it will also be adversely affected.
Up to now, there are no relevant reports or patents at home and abroad to effectively reconcile this application contradiction

Method used

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  • Bone regeneration multiple bionic scaffold material and preparation method thereof
  • Bone regeneration multiple bionic scaffold material and preparation method thereof
  • Bone regeneration multiple bionic scaffold material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A preparation method for multiple biomimetic scaffold materials for bone regeneration, comprising the following steps:

[0048] (1) Add biologically active nano-inorganic particles into the water-soluble natural protein solution, and use a magnetic stirrer to stir at 1000rpm for 30 minutes to mix evenly to obtain a mixed solution I; wherein, the biologically active nano-inorganic particles are nano-hydroxyphosphorus with an average particle size of 120nm Limestone; the concentration of water-soluble natural protein solution is 12wt%; water-soluble natural protein is silk fibroin;

[0049] (2) Add nanofiber bundles in batches to mixed solution I, and use a magnetic stirrer to stir at 1000rpm for 1 hour to mix uniformly to obtain mixed solution II; wherein, the average diameter of the fibers in the nanofiber bundles is 130nm; and the material of the nanofiber bundles is bacterial cellulose;

[0050] The mass ratio of water-soluble natural protein to nanofiber bundles is ...

Embodiment 2

[0062] A preparation method for multiple biomimetic scaffold materials for bone regeneration, comprising the following steps:

[0063] (1) Add biologically active nano-inorganic particles into the water-soluble natural protein solution, and use a magnetic stirrer to stir at 1000rpm for 30 minutes to mix evenly to obtain a mixed solution I; wherein, the biologically active nano-inorganic particles are nano-biologically active particles with an average particle size of 20nm. Glass; the concentration of the water-soluble natural protein solution is 10wt%; the water-soluble natural protein is sericin;

[0064] (2) Add nanofiber bundles in batches to mixed solution I, and use a magnetic stirrer to stir at 1000rpm for 1 hour to mix uniformly to obtain mixed solution II; wherein, the average diameter of the fibers in the nanofiber bundles is 330nm; and the material of the nanofiber bundles for silk;

[0065] The mass ratio of water-soluble natural protein to nanofiber bundles is 20:...

Embodiment 3

[0073] A preparation method for multiple biomimetic scaffold materials for bone regeneration, comprising the following steps:

[0074] (1) Add biologically active nano-inorganic particles into the water-soluble natural protein solution, and use a magnetic stirrer to stir at 1000rpm for 30 minutes to mix evenly to obtain a mixed solution I; wherein, the biologically active nano-inorganic particles are nano-calcium phosphate with an average particle size of 60nm ; The concentration of the water-soluble natural protein solution is 12wt%; The water-soluble natural protein is collagen;

[0075] (2) Add nanofiber bundles in batches to mixed solution I, and use a magnetic stirrer to stir at 1000rpm for 1 hour to mix uniformly to obtain mixed solution II; wherein, the average diameter of the fibers in the nanofiber bundles is 97nm; and the material of the nanofiber bundles is polylactic acid;

[0076] The mass ratio of water-soluble natural protein to nanofiber bundles is 20:4;

[0...

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Abstract

The invention relates to a bone regeneration multiple bionic scaffold material and a preparation method thereof. The method comprises the following steps: taking a mixed solution of bioactive nano inorganic particles, water-soluble natural protein and nanofiber bundles as a raw material, and carrying out pre-freezing, freezing treatment, freeze drying and post-treatment to obtain the bone regeneration multiple bionic scaffold material. The bone regeneration multiple bionic scaffold material comprises a lamellar material and an intercalation structure dispersed between layers of the lamellar material, and the intercalation structure is composed of nanofiber bundles and bioactive nano inorganic particles evenly and continuously distributed on the surfaces of the nanofiber bundles; the mass ratio of the water-soluble natural protein to the nanofiber bundle is 20: (2-4); in the multiple bionic scaffold material for bone regeneration, the content of the bioactive nano inorganic particles is 20-35 wt%; the preparation method of the bone regeneration multiple bionic scaffold material is simple in process and good in controllability; the prepared multiple bionic scaffold material for bone regeneration is good in mechanical property, material surface roughness, cell adhesion growth and material osteogenesis activity.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and relates to a multiple bionic scaffold material for bone regeneration and a preparation method thereof. Background technique [0002] Bone in the body is a kind of dense connective tissue, which plays an important role in life activities. Under normal circumstances, bone tissue has a certain ability to regenerate and self-repair, but large bone defects caused by severe trauma, tumor resection, traffic accidents, etc. can only be repaired by bone grafting. There are many deficiencies in the current transplantation techniques, such as lack of donors, secondary trauma, concurrent inflammation, immune rejection, and limited osteogenesis. The development of bone tissue engineering technology provides a new therapeutic approach for bone repair. The preparation of multiple biomimetic scaffold materials with bone regeneration will undoubtedly speed up the repair of bone defects. Silk fi...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/22A61L27/24A61L27/12A61L27/10A61L27/02A61L27/20A61L27/18A61L27/36A61L27/50A61L27/54A61L27/56
CPCA61L27/227A61L27/24A61L27/12A61L27/10A61L27/025A61L27/20A61L27/18A61L27/3604A61L27/365A61L27/50A61L27/54A61L27/56A61L2430/02A61L2400/12C08L89/00C08L1/02C08L67/04
Inventor 姚响张耀鹏谷敏婧范苏娜王文波
Owner DONGHUA UNIV
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