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Preparation method of an easy-to-assemble self-heating porous titanium-based drug delivery atomizer core

An atomizing core and porous titanium technology, which is applied in the field of preparation of self-heating porous titanium-based drug delivery atomizing cores, can solve problems such as low resistivity of titanium alloys, and achieve controllable porosity, free and flexible design, and various molding methods. Effect

Active Publication Date: 2022-01-11
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, in order to realize the self-heating of the drug atomization core, the resistivity of the porous titanium-based drug atomizer core is improved by adding alloy elements to solve the problem of low resistivity of the titanium alloy itself; through compression molding, injection molding and gel injection Porous titanium-based drug delivery atomization cores can be prepared by using technologies such as moulds, which can realize the customization of the shape and size of the atomization cores, making the design more free and flexible

Method used

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  • Preparation method of an easy-to-assemble self-heating porous titanium-based drug delivery atomizer core
  • Preparation method of an easy-to-assemble self-heating porous titanium-based drug delivery atomizer core

Examples

Experimental program
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Effect test

Embodiment 1

[0037] To prepare an easy-to-assemble self-heating porous titanium-based drug delivery atomization core, the preparation is as follows:

[0038] (1) Titanium powder, 30wt.% iron powder, and 20wt.% potassium chloride were weighed according to the proportion, and then mixed in a mixer for 2 hours, and the mixed powder was obtained after uniform mixing.

[0039] (2) Mix the mixed powder with 5vol.% paraffin wax, perform ball milling for 0.5h, then granulate, and pass through a 100-mesh sieve to obtain the material for pressing samples.

[0040] (3) Apply lubricating oil or zinc stearate on the surface of the mold, put the material for pressing the sample into the pressing mold of the target shape, press and form under the pressure of 50MPa, hold the pressure for 10s, and get the green body of the desired shape after taking it out .

[0041] (4) Put the green body in a sintering furnace, carry out argon sintering, keep it at 400°C for 4 hours, then keep it at 1200°C for 90 minute...

Embodiment 2

[0043] To prepare an easy-to-assemble self-heating porous titanium-based drug delivery atomization core, the preparation is as follows:

[0044] (1) Weigh titanium alloy powder and aluminum powder according to a certain weight ratio of 4:1, and add 20wt.% sodium chloride, and then put them into a mixer for mixing. The mixing time is 6 hours, and the mixed mixture is obtained after uniform mixing. powder;

[0045] (2) Mix the mixed powder with the plastic-based binder for injection in a certain proportion, wherein the mixed powder accounts for 60vol.%, and the binder accounts for 40vol.%. The mixture is mixed for 0.5h by ball milling, and then mixed in the internal mixer Carry out kneading, the kneading temperature is 180°C, and the duration is 60min;

[0046](3) Put the mixed material into the crushing and granulating machine for crushing and granulating, and then obtain the feeding material for injection;

[0047] (4) First install the mold of the target shape in place, inj...

Embodiment 3

[0051] To prepare an easy-to-assemble self-heating porous titanium-based drug delivery atomization core, the preparation is as follows:

[0052] (1) Weigh titanium powder, copper powder, and aluminum powder according to a certain ratio, wherein titanium powder: copper powder: aluminum powder = 5:1:2, and add 10wt.% paraffin, and use a mixer for mixing , the mixing time is 3 hours, and the mixed powder is obtained after uniform mixing;

[0053] (2) Mix the mixed powder and toluene solvent in a certain proportion, wherein the mixed powder accounts for 70vol.%, the binder accounts for 30wt%, then add 0.5wt.% oleic acid, 0.2wt.% PVB solution, and mix for 1h , to obtain a mixed slurry;

[0054] (3) Pour the mixed slurry into the silica gel bag of the target shape, dry at 40°C for 4 hours, and wait for it to solidify and form;

[0055] (4) taking out the dried green body from the sheath to obtain the atomizing core green body;

[0056] (5) Place the atomizing core blank in a sint...

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Abstract

The invention relates to a preparation method of a self-heating porous titanium-based drug delivery atomizing core which is easy to assemble, and belongs to the field of porous functional materials. The present invention adopts a slot-type structure to realize the assembly of the porous titanium-based drug atomization core, and increases the resistivity of the porous titanium-based drug atomizer core by adding alloy elements to realize self-heating of the drug atomizer core. Molding and gel injection molding techniques are used to manufacture self-heating porous titanium-based drug delivery atomizer cores. In the present invention, aiming at the problem of difficult assembly of traditional atomizing cores, it is proposed to use a slotted structure to realize the assembly of porous titanium-based drug atomizing cores, which saves the use of traditional heating resistance layer materials and avoids the high temperature sintering process of resistance wires. Oxidation, brittleness and other problems occur in the drug delivery atomization core; in order to realize the self-heating of the drug delivery atomization core, the resistivity of the porous titanium-based drug delivery atomization core is improved by adding alloy elements, and the functions of drug storage and heating drug oil are integrated, which is convenient for installation , greatly reduce the cost of manual assembly, facilitate the realization of automated production lines, and have the advantages of high applicability.

Description

technical field [0001] The invention belongs to the field of porous functional materials, and provides a method for preparing an easy-to-assemble self-heating porous titanium-based drug delivery atomizing core by various molding methods including compression molding, injection molding, and gel injection molding. Background technique [0002] Titanium not only has high specific strength, good oxidation resistance and corrosion resistance, but also has the advantages of safety, non-toxicity, and controllable pores, so it is often used in medical skeleton materials, filter materials, etc. Therefore, the porous titanium-based material is used as the matrix of the atomizing core, and the drug is conducted and atomized by an external power supply, which has the characteristics of safety, non-toxicity, anti-oxidation, corrosion resistance, and good chemical stability. However, due to the low resistivity of titanium, the porous titanium-based atomizing core cannot achieve self-heati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F3/11B22F3/22B22F5/10B22F9/04C22C14/00
CPCB22F3/11B22F3/1021B22F3/1007B22F9/04B22F5/10B22F3/225C22C14/00B22F2009/043
Inventor 杨芳常慧荣张耕秋郭志猛秦乾陈存广祁妙邵艳茹
Owner UNIV OF SCI & TECH BEIJING
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