A kind of quaternary ammonium salt polysulfone/polyvinyl alcohol composite hydrogel, preparation method and application

A technology of composite hydrogel and polyvinyl alcohol, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, aerosol delivery, etc. Difficult to remove and other problems, to achieve the effect of good adsorption

Active Publication Date: 2022-03-22
河南省科学院同位素研究所有限责任公司 +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Polysulfone is a commercial polymer with excellent performance, which has the characteristics of high thermal stability, hydrolysis resistance, non-toxicity, radiation resistance and good biocompatibility. However, polysulfone is basically insoluble in water and needs to be dissolved in water After mixing with polyvinyl alcohol aqueous solution in a neutral organic solvent, it is prepared into a hydrogel in the presence of other auxiliary reagents. The disadvantage is that the organic solvent and auxiliary reagents tend to remain in the hydrogel and are difficult to remove.
Francis N.Muya and his collaborators reported the preparation of polysulfone / polyvinyl alcohol hydrogel in 2014 (Journal of Surface Engineered Materials and Advanced Technology, 2014, 4, 227-236). mol / L DMF solution, take 5ml of the above solution and put it into a round bottom flask, add 2.6g of polyvinyl alcohol powder, 1mL of glutaraldehyde crosslinking agent solution and 1mL of 2M / L hydrochloric acid catalyst under stirring conditions, at 75 Stop the reaction after reacting for 3 hours at ℃, and store it at room temperature for 10 days to complete the cross-linking reaction. The polysulfone hydrogel prepared by this method has DMF solvent and cross-linking agent residues, which is difficult to handle later.

Method used

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  • A kind of quaternary ammonium salt polysulfone/polyvinyl alcohol composite hydrogel, preparation method and application
  • A kind of quaternary ammonium salt polysulfone/polyvinyl alcohol composite hydrogel, preparation method and application
  • A kind of quaternary ammonium salt polysulfone/polyvinyl alcohol composite hydrogel, preparation method and application

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Embodiment 1

[0038] A preparation method of quaternary ammonium polysulfone / polyvinyl alcohol composite hydrogel, comprising the following steps:

[0039] (1) Dissolve 10g of polysulfone in 500mL of anhydrous chloroform at 50°C, N 2 Under protection, 9g of paraformaldehyde, 50mL of trimethylchlorosilane, and 1.6g of anhydrous tin tetrachloride were sequentially added under stirring. During the reaction, nuclear magnetic detection followed the reaction. When the degree of chloromethylation substitution was greater than 1.0, see figure 1 Said, the degree of substitution is calculated according to formula (I), the reaction solution is poured into a large amount of ethanol, precipitated, filtered and dried; the prepared chloromethylated polysulfone is put into 100mL of 10wt% trimethylamine aqueous solution , stir overnight to obtain water-soluble quaternary ammonium polysulfone, remove most of the trimethylamine under reduced pressure, and then dialyze through a dialysis bag with a molecular w...

Embodiment 2

[0045] A preparation method of quaternary ammonium polysulfone / polyvinyl alcohol composite hydrogel, comprising the following steps:

[0046] (1) Dissolve 10g of polysulfone in 500mL of anhydrous chloroform at 50°C, N 2 Under protection, 9g of paraformaldehyde, 50mL of trimethylchlorosilane, and 1.6g of anhydrous tin tetrachloride were sequentially added under stirring. During the reaction, nuclear magnetic detection followed the reaction. When the degree of chloromethylation was greater than 1.5, see figure 2 As shown, the reaction solution was poured into a large amount of ethanol, precipitated, filtered and dried; the prepared chloromethylated polysulfone was put into 100ml of 15wt% trimethylamine aqueous solution, and stirred overnight to obtain a water-soluble quaternary ammonium polysulfone Sulfone, remove most of the trimethylamine under reduced pressure, and then dialyze through a dialysis bag with a molecular weight cut-off of 2000Da to remove the residual trimethyla...

Embodiment 3

[0052] A preparation method of quaternary ammonium polysulfone / polyvinyl alcohol composite hydrogel, comprising the following steps:

[0053] (1) Dissolve 10g of polysulfone in 500mL of anhydrous chloroform at 50°C, N 2 Under protection, 9g of paraformaldehyde, 50mL of trimethylchlorosilane, and 1.5g of anhydrous tin tetrachloride were sequentially added under stirring. During the reaction, nuclear magnetic detection was used to track the reaction. When the degree of chloromethylation substitution was greater than 1.5, the reaction liquid Pour into a large amount of ethanol, precipitate out, filter and dry; put the prepared chloromethylated polysulfone into 100ml 13wt% trimethylamine aqueous solution, stir overnight to obtain water-soluble quaternary ammonium polysulfone, remove under reduced pressure Most of the trimethylamine is dialyzed to remove the residual trimethylamine through a dialysis bag with a molecular weight cut-off of 3000Da. The dialysis time is 24 hours, and ...

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Abstract

The invention provides a quaternary ammonium salt polysulfone / polyvinyl alcohol composite hydrogel, which belongs to the technical field of new functional polymer materials. The method comprises the following steps: preparing quaternary ammonium polysulfone solids; taking quantitative quaternary ammonium polysulfone solids and polyvinyl alcohol and respectively uniformly dispersing them in water solvents to obtain quaternary ammonium polysulfone aqueous solutions and polyvinyl alcohol aqueous solutions; Ammonium salt polysulfone aqueous solution and polyvinyl alcohol aqueous solution are mixed uniformly, left standing at 50-60°C for 24h-48h, and then sterilized by gamma ray or electron beam radiation to obtain the quaternary ammonium polysulfone / polyvinyl alcohol composite Hydrogels. The quaternary ammonium salt polysulfone / polyvinyl alcohol composite hydrogel prepared by the invention has good adsorption to ultraviolet light (wavelength less than 390nm), antibacterial effect and no cytotoxic effect.

Description

technical field [0001] The invention belongs to the technical field of new functional polymer materials, and in particular relates to a quaternary ammonium salt polysulfone / polyvinyl alcohol composite hydrogel, a preparation method and an application thereof. Background technique [0002] Hydrogel is formed by the cross-linking of hydrophilic polymer chains in water, stores a large amount of water, has good biocompatibility and local sustained release ability, and is widely used in the fields of drug sustained release and wound dressing. Polyvinyl alcohol is a widely used water-soluble polymer material. The hydrogel prepared from it has the characteristics of low toxicity, good mechanical properties, and good biocompatibility, and has a wide range of applications in the field of biomedicine. , can maintain a certain shape and has a series of unique properties. [0003] Polysulfone is a commercial polymer with excellent performance, which has the characteristics of high ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/28C08L29/04C08L81/06A61K9/06A61K47/32A61K47/34A61L26/00A61P31/04
CPCC08J3/075C08J3/28A61L26/008A61L26/0066A61L26/0095A61K9/06A61K47/32A61K47/34A61P31/04C08J2329/04C08J2481/06C08L29/04C08L81/06
Inventor 杨明成张本尚刘树博陈阳郭文慧什马奈·瓦季姆·弗拉季米罗维奇王允田青亮王宏正梁运增
Owner 河南省科学院同位素研究所有限责任公司
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