Interferon stimulating protein targeting compound, radiomarker thereof, and preparation method and application of interferon stimulating protein targeting compound and radiomarker

A compound and interferon technology, applied in the fields of radiopharmaceuticals and medical imaging, to achieve the effects of simple preparation method, short labeling time and strong labeling ability
CN112920172AActive Publication Date: 2021-06-08XIAMEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XIAMEN UNIV
Publication Date
2021-06-08

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Abstract

The invention provides a dimeric amido benzimidazole compound. The structure of the dimeric amido benzimidazole compound is shown as a formula (I), wherein R0 is an integer of n from 0 to 5. The invention also provides a compound with anti-tumor activity and a radionuclide labeled compound targeted by interferon stimulating protein, wherein the compound is based on the dimeric amido benzimidazole compound. The dimeric amido benzimidazole compound has high affinity and high specificity to interferon stimulating protein, the compound with anti-tumor activity has the characteristic of activating an STING pathway in vitro, and the radionuclide labeled compound has the advantages that target uptake and non-target uptake are obviously compared, and the lipid solubility can be changed by introducing nuclides with different properties so that the application scene is greatly widened, and the compound can be combined with treatment nuclides for tumor treatment, and even can be used for immunotherapy.
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Description

technical field

[0001] The invention belongs to the technical field of radiopharmaceuticals and medical imaging, and in particular relates to a receptor molecular targeting compound and a preparation method thereof. Background technique

[0002] Tumor is currently the primary killer threatening human health. In recent years, tumor immunotherapy has made outstanding achievements in improving the treatment of certain types of tumors, completely changing the status quo of tumor treatment, and has become another effective treatment for cancer following surgery, radiotherapy, chemotherapy, and targeted therapy. In 2018, the award of the Nobel Prize in Physiology and Medicine affirmed a completely new principle of cancer treatment by stimulating the innate ability of the body's immune system to attack tumor cells, and changed the treatment paradigm from immune enhancement to immune normalization. Tumor immunotherapy is mainly divided into two types: cellular immunotherapy and imm...

Claims

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