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A kind of multi-arm polyethylene glycol-based polyphenol compound and its coating preparation and application method
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A technology for multi-arm polyethylene glycol and phenolic compounds, which is applied in the field of preparation of polyethylene glycol derivatives, can solve the problems of limited functionalization and application, and the coating cannot form a metal network frame structure, and achieves a wide range of applications and improved Biocompatible, high-yield effects
Active Publication Date: 2022-02-15
SOUTHWEST JIAOTONG UNIV
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The title of the patented invention is a method for preparing a coating with nitric oxide (NO) catalytic activity. The technical scheme adopted is to rely on the chemical coupling of compounds with ortho-phenolic structures with organic selenium or organic sulfides and copper ions, Coordination reaction and self-assemblypolymerization form a composite material, however, the preparation of the coating does not introduce polymers with excellent biocompatibility, and the prepared coating cannot form a metal network framework structure, which limits its subsequent functionalization and application
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Embodiment 1
[0054] Embodiment 1: Preparation of three-arm polyethylene glycol-based polyphenol compound
[0055]
[0056] S1: Weigh 0.42g of 3,4-dihydroxybenzaldehyde, add it to 20ml of anhydrousmethanol, heat and stir at 70°C under an argonatmosphere to dissolve;
[0057] S2: Weigh 0.51 g of three-arm polyethylene glycol amine (molecular weight: 500), add 20 ml of anhydrousmethanol to dissolve, add dropwise to the solution in step S1, and continue stirring for 3 hours;
[0058] S3: After standing still, a precipitate precipitated, filtered with suction, washed with absolute ethanol several times, and dried in vacuum to obtain a three-armed polyethylene glycol-based polyphenol compound.
Embodiment 2
[0059] Embodiment 2: Preparation of three-arm polyethylene glycol-based polyphenol compound
[0060]
[0061] S1: Weigh 0.46g of 3,4,5-trihydroxybenzaldehyde, add it to 20ml of anhydrousmethanol, heat and stir at 70°C under an argonatmosphere to dissolve;
[0062] S2: Weigh 0.51 g of three-arm polyethylene glycol amine (molecular weight: 500), add 20 ml of anhydrous methanol to dissolve, add dropwise to the solution in step S1, and continue stirring for 3 hours;
[0063] S3: After standing still, a precipitate precipitated, filtered with suction, washed with absolute ethanol several times, and dried in vacuum to obtain a three-armed polyethylene glycol-based polyphenol compound.
Embodiment 3
[0064] Embodiment 3: Preparation of three-arm polyethylene glycol-based polyphenol compound
[0065]
[0066] S1: Weigh 0.46g of 2,4,5-trihydroxybenzaldehyde, add it to 20ml of anhydrous methanol, heat and stir at 70°C under an argonatmosphere to dissolve;
[0067] S2: Weigh 0.51 g of three-arm polyethylene glycol amine (molecular weight: 500), add 20 ml of anhydrous methanol to dissolve, add dropwise to the solution in step S1, and continue stirring for 3 hours;
[0068] S3: After standing still, a precipitate precipitated, filtered with suction, washed with absolute ethanol several times, and dried in vacuum to obtain a three-armed polyethylene glycol-based polyphenol compound.
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Abstract
The invention discloses a multi-arm polyethylene glycol-based polyphenol compound and its coating preparation and application methods. The provided multi-arm polyethylene glycol-based polyphenol compound is synthesized by a one-pot method of solution and can be obtained by simple separation. The product has simple preparation process, easy operation and high yield. The Schiff base reaction between multi-arm polyethylene glycol amine and phenolic aldehyde is adopted, and a polyphenol structure is introduced at the end of the multi-arm polyethylene glycol, which can chelate metal ions to form a ring-shaped chelate. The present invention also provides a preparation method of a multi-arm polyethylene glycol-based polyphenol compound and its coating, wherein the target modified material is soaked in a mixed solution composed of a multi-arm polyethylene glycol-based polyphenol compound and a soluble metal salt A metal network framework coating is constructed on its surface, which synergistically improves the biocompatibility of the material with polyethylene glycol (PEG), and has potential application prospects in the surface modification of implant materials such as cardiovascular.
Description
technical field [0001] The invention relates to the field of preparation of polyethylene glycol derivatives, in particular to a multi-arm polyethylene glycol-based polyphenol compound and a coating preparation and application method thereof. Background technique [0002] Polyethylene glycol (PEG) is a -CH 2 -CH 2 -O- is a water-soluble polyether repeating unit, has very low immunogenicity, antigenicity and toxicity, has been approved by the US Food and Drug Administration, and is currently widely used in the fields of food, hygiene and beauty and medicine. In both water and organic solvents, PEG exhibits excellent solubility, and the polymer has excellent biocompatibility, can be dissolved in interstitial fluidin vivo, and can be quickly excreted by the body without any toxic side effects . [0003] Polyethylene glycol (PEG) has been widely used in the field of biomedical materials, but the application range and efficacy of ordinary PEG are greatly limited due to the lac...
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