Bone repair titanium-molybdenum-based hydroxyapatite composite material and preparation method thereof

A technology based on hydroxyapatite and hydroxyapatite, which is used in prosthesis, medical science and other directions, can solve the problems of low elastic modulus, mismatched mechanical properties, and high compressive strength, and achieves low elastic modulus and reduced The effect of tissue defects and high compressive strength

Active Publication Date: 2021-06-29
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The invention uses harmless titanium-molybdenum alloy and adds hydroxyapatite powder, prepares high-fine powder by means of high-energy ball milling, and uses a high-temperature tube furnace to realize gradient degreasing and sintering. The purpose is to further improve the biological activity of artificial implants and solve the problem of The mechanical properties of

Method used

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  • Bone repair titanium-molybdenum-based hydroxyapatite composite material and preparation method thereof
  • Bone repair titanium-molybdenum-based hydroxyapatite composite material and preparation method thereof
  • Bone repair titanium-molybdenum-based hydroxyapatite composite material and preparation method thereof

Examples

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Embodiment 1

[0035] A preparation method of a titanium-molybdenum-based hydroxyapatite composite material for bone repair, the preparation method comprising the following steps:

[0036] (1) According to the mass percentage of Ti (purity: 99.99%, particle size: 500 mesh): 90%, Mo (purity: 99.99%, particle size: 400 mesh): 10%, weigh 18.00g Ti and 2.00g Mo powder respectively , take by weighing 0.40g stearic acid powder simultaneously;

[0037](2) Grind the raw materials weighed in step (1) in the stainless steel ball mill tank of the planetary ball mill (the ball milling medium is stainless steel grinding balls with a diameter of 4-10mm, and the mass ratio of the ball to material is 10:1). The ball milling speed is 400r / min , the ball milling time is 6h, and the titanium-molybdenum metal powder with a fine particle size is obtained, and the particle size is 5-50 μm;

[0038] (3) Add 2.00g of hydroxyapatite powder (purity 99.99%, average particle diameter is 15 μ m spherical micron powder)...

Embodiment 2

[0043] The rest of the steps in this example are the same as in Example 1, except that 1.4 g of hydroxyapatite powder (a spherical micron-sized powder with a purity of 99.99% and an average particle size of 15 μm) is added to obtain a titanium-molybdenum-based hydroxyapatite composite material , Ti-10Mo / 7HA.

[0044] The density of the Ti-10Mo / 7HA composite material prepared in this example is 4.39g / cm 3 , the elastic modulus is 46.46GPa, and the compressive strength is 1153MPa. The biological activity of the composite material prepared in this embodiment is evaluated by using the in vitro biomimetic mineralization experiment. The sample is soaked in simulated body fluid at a temperature of 37°C. Change the solution once a day, soaking time is 7 days, if the surface deposits figure 2 The bone-like apatite layer shown shows that the material has good biological activity. Experimental results such as figure 2 As shown, a large amount of spherical bone-like apatite was depos...

Embodiment 3

[0046] The remaining steps of this embodiment are the same as in Example 1, except that 1.00 g of hydroxyapatite powder (a spherical micron-sized powder with a purity of 99.99% and an average particle size of 15 μm) is added to obtain a titanium-molybdenum-based hydroxyapatite composite material, Ti-10Mo / 5HA.

[0047] The density of the Ti-10Mo / 5HA composite material prepared in this embodiment is 4.51g / cm 3 , the modulus of elasticity is 48.69GPa, and the compressive strength is 1486MPa.

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Abstract

The invention discloses a bone repair titanium-molybdenum-based hydroxyapatite composite material and a preparation method thereof. The composite material is prepared by mixing a titanium-molybdenum alloy, a process control agent and hydroxyapatite. The prepared composite material is low in elasticity modulus (30-50 GPa), high in compressive strength (500-1550 MPa) and high in hardness (300-520 HV), contains a large number of bioactive ceramic phases (CaTiO3, Ca3 (PO4) 2, HA and the like), is beneficial to induction of osseointegration, has excellent mechanical properties and biological activity, and can be used for bone repair and bone replacement.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical materials, in particular to a titanium-molybdenum-based hydroxyapatite composite material for bone repair and a preparation method thereof. Background technique [0002] Among the artificial biomedical materials currently in clinical use, titanium and titanium alloys have excellent performance, and are considered to be the first choice materials for hard tissue replacement and repair such as artificial joints, spinal orthopedic internal fixation systems, and dental implants. Pure titanium (Ti) and Ti-6Al-4V are currently the most widely used titanium alloys for bone repair, but aluminum (Al) and vanadium (V) have been proven to be toxic to the human body, and their elastic modulus does not match that of human bone. lead to "stress shielding phenomenon". Adding Nb, Ta, Zr, Mo and other non-toxic elements to develop a new type of β-type biomedical titanium alloy can effectively re...

Claims

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Application Information

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IPC IPC(8): C22C14/00C22C32/00A61L27/06A61L27/12C22C1/05
CPCC22C14/00C22C32/0089C22C1/05A61L27/06A61L27/12
Inventor 颉芳霞黄家兵
Owner JIANGNAN UNIV
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