Compound polysaccharide with effect of reducing blood fat as well as preparation method and application of compound polysaccharide

A compound polysaccharide and hypolipidemic technology, which is applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve the problems of complex preparation methods, troublesome operations, and no reports on research on hypolipidemic activity, and achieves the extraction process. Simple, low cost, good development and application prospects

Pending Publication Date: 2021-07-02
天津市食品安全检测技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A lot of research work has been carried out on the structure and biological activity of single polysaccharides derived from the above-mentioned homologous substances of medicine and food, but the separation and purification of polysaccharides with homology of medicine and food and their blood lipid-lowering activity have not been reported yet.
Moreover, most of the complex polysaccharides are prepared by first preparing the polysaccharide extracts of each component separately and then mixing them. The preparation method is complicated and the operation is troublesome.

Method used

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  • Compound polysaccharide with effect of reducing blood fat as well as preparation method and application of compound polysaccharide
  • Compound polysaccharide with effect of reducing blood fat as well as preparation method and application of compound polysaccharide
  • Compound polysaccharide with effect of reducing blood fat as well as preparation method and application of compound polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Hawthorn, lotus leaf, tartary buckwheat, cassia, medlar, and poria were dried at 60°C to constant weight, put into a grinder, and crushed at a speed of 42000r / min for 3 minutes to obtain hawthorn, Lotus leaf, tartary buckwheat, cassia seed, wolfberry, poria cocos meal.

[0038] Hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry, and poria cocos coarse powder were rehydrated at room temperature, and distilled water was added to adjust the moisture content of each raw material coarse powder to 15%, soaked for 12 hours, and then put into the material bin for steam explosion. The explosion pressure is 2.0MPa, the pressure holding time is 90s, and then dried at 60°C to constant weight to obtain hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry, and poria powder.

[0039] Mix hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry, and poria fine powder according to the mass ratio of 4:2:2:1.5:1:1, add distilled water, and perform ultrasonic...

Embodiment 2

[0044] Hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry, and poria cocos were dried at 60°C to constant weight, put into a grinder, and crushed at a speed of 50,000r / min for 1 minute to obtain hawthorn, Lotus leaf, tartary buckwheat, cassia seed, wolfberry, poria cocos meal.

[0045] Hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry, and poria cocos coarse powder were rehydrated at room temperature, and distilled water was added to adjust the moisture content of each raw material coarse powder to 30%. The soaking time was 12 hours, and then put into the material bin for steam explosion. The explosion pressure is 2.5MPa, the pressure holding time is 150s, and then dried at 60°C to constant weight to obtain hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry, and poria powder.

[0046] Mix hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry, and poria fine powder according to the mass ratio of 4:2:2:1.5:1:1, add distilled wate...

Embodiment 3

[0051] Hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry, and poria cocos were dried at 60°C to constant weight, put into a grinder, and crushed at a speed of 30,000r / min for 5 minutes to obtain hawthorn, Lotus leaf, tartary buckwheat, cassia seed, wolfberry, poria cocos meal.

[0052] Hawthorn, lotus leaf, tartary buckwheat, cassia seed, medlar, and poria cocos coarse powder were rehydrated at room temperature, and distilled water was added to adjust the moisture content of each raw material coarse powder to 5%. The soaking time was 6 hours, and then put into the material bin for steam explosion. The explosion pressure is 0.5MPa, the pressure holding time is 50s, and then dried at 60°C to constant weight to obtain hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry, and poria powder.

[0053] Mix hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry, and poria fine powder according to the mass ratio of 4:2:2:1.5:1:1, add distilled water, an...

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Abstract

The invention discloses a compound polysaccharide with an effect of reducing blood fat as well as a preparation method and application of the compound polysaccharide. The total sugar content of the compound polysaccharide is 97.87-101.87%, the average molecular weight of the compound polysaccharide is 3.5-4.0*10<4> Da, and the compound polysaccharide is prepared from glucose, xylose, mannose, arabinose and galactose according to the molar mass ratio of (93.6-94.8): (2.70-2.73): (2.70-2.73): (0.50-0.51): (0.50-0.51). The preparation method comprises the following steps of successively carrying out crushing, steam explosion and uniform mixing on hawthorn, lotus leaf, tartary buckwheat, cassia seed, wolfberry and Poria cocos, successively carrying out water extraction, concentration, alcohol precipitation, dialysis, freeze drying, repeated freeze thawing method deproteinization, and Sephadex G-75 gel chromatographic column separation and purification so as to obtain a pure compound polysaccharide product. The prepared compound polysaccharide is high in purity, high in blood fat reducing activity, simple and convenient in extraction process, low in cost and high in operability, and the harm to the environment and human bodies caused by the use of a large number of toxic organic solvents is avoided. The compound can be widely applied to the industries of medicines, health foods and the like, can also be used as an intermediate to be widely applied to various fields of blood fat reduction, and has good development and application prospects.

Description

technical field [0001] The invention belongs to the field of medicine and health food, and specifically relates to a compound polysaccharide with hypolipidemic effect and its separation and purification preparation method and application, especially a compound polysaccharide with blood lipid-lowering activity and its separation and purification preparation method and application. Background technique [0002] Hyperlipidemia is closely related to the pathophysiology of cardiovascular diseases, can aggravate and accelerate the process of atherosclerosis, and pose a huge threat to human health all over the world (shortened life span, high mortality, etc.). Changing diet and taking lipid-lowering drugs can regulate lipid metabolism, reduce blood lipids, and then treat hyperlipidemia. However, lipid-lowering drugs (niacin, statins, and fibrates) have side effects such as hepatitis, exogenous rash, and constipation. Plant-derived polysaccharides are biologically active ingredient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P3/06A23L33/125
CPCC08B37/0003C08B37/006A61K31/715A61P3/06A23L33/125A23V2002/00
Inventor 杨栩曹东丽甄鹏徐慧静朱锋翟雨佳李永发
Owner 天津市食品安全检测技术研究院
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