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Method for separating and purifying 223Ra from spallation reaction caused by high-energy proton beam irradiation of < 232 > Th target

A high-energy proton and irradiation technology, applied in the fields of reactor/accelerator external conversion, radiation-converting chemical element devices, pharmaceutical formulations, etc. problems such as low separation efficiency, to avoid product loss, reduce material costs, and reduce radiation doses

Active Publication Date: 2021-07-02
INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing reports require repeated concentration and evaporation, and the operation is discontinuous, resulting in large product loss, low recovery rate and separation efficiency, which still cannot meet the needs of the future. 223 Scale production and demand of Ra
[0005] Although my country has also approved in August 2020 223 Ra is used for clinical treatment and application, but its source is completely dependent on imports. This situation will cause great inconvenience to the research and development of nuclear medicine in my country, and it is urgent for domestic scholars to actively fill in 223 Blanks in related fields such as Ra production and separation and purification

Method used

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  • Method for separating and purifying 223Ra from spallation reaction caused by high-energy proton beam irradiation of &lt; 232 &gt; Th target
  • Method for separating and purifying 223Ra from spallation reaction caused by high-energy proton beam irradiation of &lt; 232 &gt; Th target
  • Method for separating and purifying 223Ra from spallation reaction caused by high-energy proton beam irradiation of &lt; 232 &gt; Th target

Examples

Experimental program
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Effect test

Embodiment 1

[0083] This example is used to illustrate the dissolution of metal thorium target, and the removal of matrix Th by two-column separation system after directly adjusting the acidity, and the target product 223 Ra and by-products 225 Feasibility of Ac separation.

[0084] The Th targets used in the present invention are metal Th powders provided by the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. They are pressed by a liquid tablet press at a pressure range of 13 MPa, with a diameter of 15 mm and a thickness of 2 to 4 mm. Photo and SEM image reference figure 1 .

[0085] Using the accelerator HIRFL of the Institute of Modern Physics, Chinese Academy of Sciences (Lanzhou), the energy is 100MeV, and the proton beam with an average current intensity of 24nA is used to irradiate No. 1 metal Th target (2.35g), and the irradiation time is 7 hours. The Th target is irradiated. The shape before and after remains the same. from figure 2 It can be seen from...

Embodiment 2

[0096] This example is used to illustrate the purification from the isolated Ra component crude product 223 Feasibility of Ra products.

[0097] Gained according to Example 1 223 The γ energy spectrum of Ra crude product components ( Figure 4 ), confirming that the removal of the 140 Ba impurity, to meet the product purity of clinical application and research of nuclear medicine. The present embodiment partly refers to the ammonium citrate complexing agent described in "Separation of Radium and Barium by Ion Exchange Method", Mao Jiajun, Atomic Energy Science and Technology, Volume 08, 1963, pages 635-637. Also, a cationic resin column and a branched DGA resin column were used in series, and the volumes of the two columns (column 3 and column 4) were 10 mL and 2 mL, respectively.

[0098] With the obtained part in embodiment 1 223 Ra crude product purification treatment, control the flow rate to 2.0mL / min, the specific washing steps are:

[0099] (a) will contain 5M nit...

Embodiment 3

[0105] This embodiment is used to illustrate recovering from the Th component solution after separation 223 Feasibility of Ra to build a simple 227 Th / 223 Ra generator.

[0106] 227 Th decays to 223Ra, and the time for the activity of the latter to reach the peak is 20.8 days. Based on the calculation results, the inventor suggested that a recovery operation can be performed 10-18 days after the Th component is separated. Then, according to whether the recovered dose meets the needs of subsequent research and application, the purified Th component is further recycled and recycled. 223 Ra products, a total of 6 to 10 times (10 to 18 days / time), so as to provide hospitals or research institutes with a higher single-day average dose 223 Ra drug.

[0107] The series system of cationic resin column and branched DGA resin column in Example 1 is also adopted, and the volumes of column 1 and column 2 are respectively 5 mL and 2 mL. On the 14th day after the Th component was s...

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Abstract

The invention relates to a method for separating and purifying 223Ra from spallation reaction caused by high-energy proton beam irradiation of < 232 > Th target, which comprises the following steps of: 1) dissolving the irradiated metal Th target by adopting a method of heating sulfuric acid and hydrofluoric acid to replenish water to obtain a dissolved solution; 2) adopting a series system of a cationic resin column and a DGA resin column, adjusting the acid of the solution, injecting the solution into a cationic resin column, loading metal ions such as a target product Ra and a by-product Ac in the solution, and eluting with a complexing agent to remove matrix Th and a large number of fission daughters; (3) leaching Ra, Ac and other metal ions loaded on the cationic resin column by adopting inorganic acid, and enabling the obtained leaching solution containing Ra, Ac and other metal ions to directly pass through the DGA resin column to respectively obtain an Ra crude product and a byproduct Ac; and 4) leaching the Ra crude product through an ammonium citrate system to obtain a 223Ra product. The invention establishes a novel process which is simple, efficient and continuous in operation, can realize the aims of separating and purifying the localized 223Ra and recycling the 223Ra for multiple times, and has very important significance for positively meeting the requirements of medical research and application in China.

Description

technical field [0001] The invention belongs to the field of medical radioactive isotope manufacture, in particular to a radioisotope irradiated from high-energy proton beams 232 Separation and purification of Th targets 223 Ra's method. Background technique [0002] Radium is an alkaline earth metal in the periodic table of elements. Because its chemical properties are very similar to calcium, it has good bone affinity and can accelerate bone renewal. 223 The average energy of the α particles emitted by Ra is 5.78MeV, and its high linear energy transfer value can effectively break the DNA double strands and kill cancer cells. kind of cancer. 223 Ra is the first alpha nuclide for clinical treatment approved by domestic and foreign drug regulatory authorities, and its drug form is 223 RaCl 2 Injection, the trade name is Xofigo. [0003] Prepared for medical use internationally 223 Ra's method, mainly from 227 Ac(t 1 / 2 =21.77y) decays to 227 Th(t 1 / 2 =18.7d), and th...

Claims

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Application Information

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IPC IPC(8): G21G1/00G21G1/10A61K51/00A61K103/00
CPCG21G1/001G21G1/10A61K51/00G21G2001/0094Y02P10/20
Inventor 谈存敏曹石巍田伟秦芝
Owner INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
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