This invention relates to a method for generating a high-purity Ac-225 radioactive beam based on an online
isotope separator. A high-energy
proton beam with an energy of 100 MeV is generated using a
cyclotron accelerator. This high-energy
proton beam is transmitted to an ISOL target chamber and bombards a
thorium carbide target within the chamber, causing a
nuclear reaction. Atoms produced in the
nuclear reaction escape from the target and interact with a specific
wavelength of incident
laser light, resulting in stimulated
ionization. The stimulated ionized radioactive nuclear beam is extracted by a high-
voltage ion source and then transmitted via a beam
transport system to a pre-analytical
magnet. The radioactive nuclear beam undergoes preliminary separation by the pre-analytical
magnet. After preliminary separation, the radioactive nuclear beam is further accelerated by a high-
voltage accelerator tube and then further separated by the main analytical
magnet to improve the purity of the beam. Compared with radiochemical separation methods, this invention offers higher separation efficiency and a shorter separation cycle, yielding Ac-225 with a purity exceeding 99%. Further purification is expected to meet the requirements of
clinical trial standards.