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Bone tissue engineering scaffold material and preparation method thereof

A technology of bone tissue engineering and scaffold material, which is applied in tissue regeneration, medical science, prosthesis, etc. It can solve the problems of uncontrollable degradation cycle, poor osteoinductivity and conductivity, and high preparation cost, and achieve good osteogenic effect and cost. The effect of low cost and simple preparation method

Pending Publication Date: 2021-07-16
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The main purpose of the present invention is to provide a bone tissue engineering scaffold material and a preparation method thereof. The scaffold material of the present invention has the aperture and porosity in line with the tissue engineering scaffold material, and has good formability, osteoinduction and conductivity; and The degradation cycle can be regulated. The bone tissue engineering scaffold material of the present invention overcomes the shortcomings of the existing scaffold materials such as uncontrollable degradation cycle, poor osteoinductivity and conductivity, and high preparation cost, and has a good osteogenesis effect. Applicable to various types of bone defect repair

Method used

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  • Bone tissue engineering scaffold material and preparation method thereof
  • Bone tissue engineering scaffold material and preparation method thereof
  • Bone tissue engineering scaffold material and preparation method thereof

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Embodiment 1

[0051] A preparation method for bone tissue engineering scaffold material, comprising the following steps:

[0052] (1) Preparation of mesoporous bioactive glass powder: Weigh 60g of absolute ethanol and add it to a beaker, then weigh 1ml of 0.5mol / L hydrochloric acid and add it to absolute ethanol, then weigh 4.0g of P123 and add it to absolute ethanol, Stir at room temperature until P123 is completely dissolved; then weigh 1.4g Ca(NO 3 ) 2 4H 2 Slowly add O into the solution, stirring while adding, until it is completely dissolved; then measure 0.69ml TEP and slowly drop it into the solution at a rate of 15 drops / min. After adding TEP, measure 7.3ml TEOS and slowly drop it into the solution In the process, the dropping rate was 15 drops / min. After all the additions were completed, the sol solution was obtained by continuous stirring at room temperature for 36 hours; The rubber is placed in a high-temperature calcining box furnace with a heating rate of 1°C / min. When the t...

Embodiment 2

[0056] A preparation method for bone tissue engineering scaffold material, comprising the following steps:

[0057] (1) Preparation of mesoporous bioactive glass powder: Weigh 60g of absolute ethanol and add it to a beaker, then weigh 1ml of 0.5mol / L hydrochloric acid and add it to absolute ethanol, then weigh 4.0g of P123 and add it to absolute ethanol, Stir at room temperature until P123 is completely dissolved; then weigh 1.4g Ca(NO 3 ) 2 4H 2 Slowly add O into the solution, stirring while adding, until it is completely dissolved; then measure 0.69ml TEP and slowly drop it into the solution at a rate of 15 drops / min. After adding TEP, measure 7.3ml TEOS and slowly drop it into the solution In the process, the dropping rate was 15 drops / min. After all the additions were completed, the sol solution was obtained by continuous stirring at room temperature for 36 hours; The rubber is placed in a high-temperature calcining box-type furnace with a heating rate of 1°C / min. When ...

Embodiment 3

[0060] A preparation method for bone tissue engineering scaffold material, comprising the following steps:

[0061] (1) Preparation of mesoporous bioactive glass powder: Weigh 60g of absolute ethanol and add it to a beaker, then weigh 1ml of 0.5mol / L hydrochloric acid and add it to absolute ethanol, then weigh 4.0g of P123 and add it to absolute ethanol, Stir at room temperature until P123 is completely dissolved; then weigh 1.4g Ca(NO 3 ) 2 4H 2 Slowly add O into the solution, stirring while adding, until it is completely dissolved; then measure 0.69ml TEP and slowly drop it into the solution at a rate of 15 drops / min. After adding TEP, measure 7.3ml TEOS and slowly drop it into the solution In the process, the dropping rate was 15 drops / min. After all the additions were completed, the sol solution was obtained by continuous stirring at room temperature for 36 hours; The rubber is placed in a high-temperature calcining box-type furnace with a heating rate of 1°C / min. When ...

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Abstract

The invention belongs to the technical field of high-tech materials, and particularly relates to a bone tissue engineering scaffold material and a preparation method thereof. According to the scaffold material disclosed by the invention, a polyglycolide-polycaprolactone diblock is used as a polymer main body material, mesoporous bioactive glass powder is used as an inorganic bioactive component, and the mesoporous bioactive glass powder is uniformly dispersed in the scaffold material. The scaffold material disclosed by the invention has the pore diameter and porosity conforming to a tissue engineering scaffold material, and has good formability, bone induction and conductivity, the degradation period of the scaffold material can be regulated and controlled, the defects that an existing scaffold material cannot be regulated and controlled in degradation period, poor in osteoinductivity and conductivity, high in preparation cost and the like are overcome, and the bone tissue engineering scaffold material has a good osteogenesis promoting effect and can be suitable for repairing various different bone defects. In addition, the preparation method of the bone tissue engineering scaffold material is simple, low in cost and suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of high-tech materials, and in particular relates to a scaffold material for bone tissue engineering and a preparation method thereof. Background technique [0002] Large bone defects caused by trauma, infection, tumor, etc. are common clinical orthopedic diseases. In terms of quantity, bone defect surgery has become human tissue transplantation second only to blood transfusion, and the clinical demand is huge. Traditional bone defect repair methods include: autologous bone graft, allogeneic bone graft, and xenograft bone graft, but these methods have major drawbacks, which greatly limit their clinical application. At present, tissue engineering method is used to construct bioactive artificial bone compounded with seed cells, scaffold materials and growth factors, which is considered to be one of the most effective methods for bone defect repair and bone reconstruction in the future. [0003] As a framewor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/54A61L27/18A61L27/10A61L27/12
CPCA61L27/10A61L27/12A61L27/18A61L27/50A61L27/54A61L27/56A61L2430/02C08L67/04
Inventor 尹光福李江峰蒲曦鸣黄忠兵廖晓明
Owner SICHUAN UNIV
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