Bionic porous titanium scaffold of CeO2 modified TiO2 variable nanotube array and preparation method thereof

Abstract

The invention discloses a preparation method of a bionic porous titanium scaffold of a CeO2 modified TiO2 variable nanotube array, which comprises the following steps: preparing a porous titanium scaffold by adopting a 3D printing technology, carrying out two-step anodic oxidation on the porous titanium scaffold, forming a dumbbell-shaped TiO2NT array on the scaffold, preparing a TiO2NT modified porous titanium scaffold, immersing the TiO2NT modified porous titanium scaffold in a Ce (NO3) 3 solution, taking out, drying, and carrying out heat treatment, thereby obtaining the bionic porous titanium scaffold of the CeO2 modified TiO2 variable nanotube array. The preparation method comprises the following steps: preparing a CeO2NP-loaded TiO2NT modified porous titanium scaffold, soaking the CeO2NP-loaded TiO2NT modified porous titanium scaffold in an rhBMP-2 solution, freeze-drying overnight, drying, coating the scaffold with a VEGF / chitosan mixed solution by using a freeze-drying method and a vacuum drying method, and preparing the bionic porous titanium scaffold by using genipin as a cross-linking agent. The stent has the advantages of being antibacterial, anti-inflammatory, capable of promoting angiogenesis and osteoblast differentiation and the like, can effectively improve the prognosis condition of bone defect repair and reconstruction, and has excellent drug slow release performance.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a CeO 2 Modified TiO 2 Biomimetic porous titanium scaffold with variable nanotube array and its preparation method. Background technique [0002] Vascularized autologous bone graft can provide the necessary biological signals and environment for rapid angiogenesis and bone formation. Because of its good osteoconductivity and osteoinductivity, it is known as the "gold standard" for bone defect repair. However, due to the large damage of the donor site and the difficulty in obtaining the donor bone, there are certain difficulties in its application. Artificially synthesized engineered bone has become an effective alternative to solve the problem of bone resources and has a good application prospect. [0003] Titanium alloy implants have good mechanical properties, chemical stability and biocompatibility, and are a common bone tissue engineering material. However, m...

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The hydrogel was prepared by ultrasonic treatment and magnetic stirring, and obtained good mechanical properties and sustained release performance. The release period of the vancomycin loaded was 15 days, but there was still 29% of the initial burst release phenomenon.

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