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Chromatographic system based on ionic liquid imprinted polymer microchip and detection method thereof

An imprinted polymer, ionic liquid technology, applied in separation methods, chemical instruments and methods, solid adsorbent liquid separation, etc., can solve problems such as poor selectivity and sensitivity, inability to eliminate interference, single measurement components, etc. Inexpensive, low cost, easy to operate

Inactive Publication Date: 2021-07-16
SHENZHEN NTEK TESTING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the photometric method is the simplest method for the determination of aldehyde compounds, but the selectivity and sensitivity are poor, and the determination components are single, and the interference of phenols and amines in the sample matrix cannot be ruled out.
The fluorescence method has the advantages of convenience and rapidity, but in the case of low detection limit, it is easily affected by factors such as temperature, wavelength and pH, resulting in poor accuracy and unstable method

Method used

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  • Chromatographic system based on ionic liquid imprinted polymer microchip and detection method thereof
  • Chromatographic system based on ionic liquid imprinted polymer microchip and detection method thereof
  • Chromatographic system based on ionic liquid imprinted polymer microchip and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1 is based on ionic liquid imprinted polymer microchip chromatographic system

[0060] The polymer microchip system based on ionic liquid imprinted consists of three major modules, such as figure 1 As shown, the injection module with the syringe pump as the main body, the separation module with the ionic liquid imprinted polymer as the core, and the spatial coupling optical communication module with the CCD detector as the key. In the system of the present invention, based on a novel functional ionic liquid imprinted polymer as a stationary phase, a microfluidic chip and optical sensing communication technology are used in parallel to construct a novel portable microchip chromatography system based on an ionic liquid imprinted polymer.

[0061] Among them, the sampling module is the sampling system, which is composed of five-channel pumps, such as figure 1 In a, b, c, d, and e, the required flow rate and the number of pumps used can be selected according to ...

Embodiment 2

[0064] Example 2 Preparation of Ionic Liquid Imprinted Polymer

[0065] Synthetic routes for ionic liquid imprinted polymers, such as figure 2 Shown:

[0066] A: Synthesis of ionic liquid monomers.

[0067] Step A-1, the whole reaction is carried out under the protection of nitrogen.

[0068] Step A-2, mix 1-bromo-hexadecane and 1-vinylimidazole in different molar ratios such as 1:1.1, 1:1.2, 1:1.4, and dissolve in 60 mL of absolute ethanol solution (analytical grade) In the solution, control the reaction temperature to 70°C, reflux through spherical condensation, and react for 72 hours.

[0069] Step A-3, rotary evaporation, removal of ethanol, washing with dichloromethane, and drying.

[0070] Step A-4, finally, collect the obtained product in a vacuum desiccator, and dry it in vacuum overnight to obtain relatively purified 1-hexadecyl-3-vinylimidazolium bromide.

[0071] B: Synthesis of ionic liquid imprinted polymers.

[0072] Step B-1, using 1-bromo-hexadecane as a...

Embodiment 3

[0075] Example 3 Aldehyde and Ketone Compound Detection Method Based on Ionic Liquid Imprinted Polymer Microchip Chromatography System

[0076] The present invention is based on the portable analysis and detection system constructed above, that is, based on the ionic liquid imprinted polymer microchip chromatographic system, which is applied to the analysis and detection of samples, including the analysis and monitoring of ten kinds of aldehyde and ketone mixtures, respectively. , the separation system and the detection system are optimized, and the chromatographic conditions are optimized to obtain the chromatogram of the detection sample.

[0077] The specific implementation is:

[0078] Test sample:

[0079]The detection sample is a standard product combined with aldehydes and ketones and DNPH. Among them, ten aldehydes and ketones and their specific concentrations are: formaldehyde 20 μg / mL, acetaldehyde, acrolein, acetone, propionaldehyde, crotonaldehyde, formaldehyde A...

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Abstract

The invention provides a chromatographic system based on the ionic liquid imprinted polymer microchip. The ionic liquid imprinted polymer is used as a stationary phase, and a micro-fluidic chip and optical sensing communication are connected in parallel, so that the detection of a sample is realized. The invention also provides a method for detecting harmful substances of aldehyde ketone compounds based on the system. The invention innovatively develops a chromatographic analysis system with high throughput and low dead volume under the micro-channel scale, is suitable for detection of different samples and on-site in-situ real-time detection through modular design in the system, overcomes the technical defects of expensive cost, single function and the like of the existing detection equipment, and has wide application prospects.

Description

technical field [0001] The invention belongs to the technical field of new functional materials and micro-analysis detection, relates to the technical field of micro-analysis and separation of harmful substances, and specifically relates to a microchip chromatography system based on ionic liquid imprinted polymer and its detection method, and a microchip based on ionic liquid imprinted polymer. Method for detection of aldehydes and ketones by chip chromatography system. Background technique [0002] In recent years, microfluidic chip technology has developed rapidly in the fields of life analysis, environmental analysis and chemical analysis due to its advantages of high throughput, high reaction efficiency, small size, low cost and easy automation. By integrating various functions, such as sample injection, pretreatment, separation, detection and calculation, into the microfluidic chip, a "lab-on-a-chip" based on the microchip platform can be constructed to replace the exis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88G01N30/74G01N30/32B01J20/281B01D15/20
CPCB01D15/20B01J20/281G01N30/32G01N30/482G01N30/74G01N30/88G01N2030/324G01N2030/326G01N2030/884
Inventor 周信光周业华廖武名李刚
Owner SHENZHEN NTEK TESTING TECH
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