Composite multi-component collagen microemulsion filler and preparation method thereof

A collagen and filler technology, applied in the field of medical cosmetology, can solve the problems of skin side effects, single use effect, poor product stability, etc., achieve good biocompatibility, delay skin aging, and improve the effect of supporting effect

Inactive Publication Date: 2021-07-23
磐升瑞祥(山东)生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently commonly used dermal fillers are mainly composed of synthetic hydroxyapatite, polylactic acid microspheres, polymethyl methacrylate microspheres and other microspheres. These dermal fillers have a long service life and good stability. However, Studies have shown that such dermal fillers have poor biocompatibility and are prone to granuloma formation
[0004] The existing collagen filler products in the domestic market include cross-linked collagen fillers and non-cross-linked collagen fillers. However, the residual cross-linking agent will cause toxic and side effects on the skin and cause a series of adverse reactions. Moreover, the main components of the existing collagen filler products on the market are collagen, anesthetic, cross-linking agent, and buffered saline solution, and the ingredients are single. The use effect is single, and a small amount of water will be separated out after being refrigerated for a long time, and the stability of the product is poor

Method used

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  • Composite multi-component collagen microemulsion filler and preparation method thereof
  • Composite multi-component collagen microemulsion filler and preparation method thereof
  • Composite multi-component collagen microemulsion filler and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Preparation of composite multi-component collagen microemulsion filler

[0036] (1) Preparation of matrix solution: add injection-grade sodium chloride to the injection-grade phosphate buffer, filter and sterilize with a 0.22 μm filter to obtain a phosphate matrix solution containing 0.9% sodium chloride;

[0037] (2) Take half of the above matrix solution, add 0.5g of vitamin E, 0.06g of sodium carboxymethyl cellulose, 1.6g of soybean lecithin, and 2.0g of poloxamer into the matrix solution, heat to 60°C, and stir until completely Dissolve, filter and sterilize through a 0.22 μm filter to obtain the oil phase;

[0038] (3) Add 0.1g of ceramide, 1.8g of proanthocyanidin, 0.5g of vitamin C, 0.1g of vancomycin, 0.3g of tetracaine hydrochloride, and 30mg of diclofenac into the remaining matrix solution, stir magnetically until completely dissolved, and obtain water Mutually;

[0039] (4) Emulsify the above-mentioned oil phase and water phase with a high-speed stirring...

Embodiment 2

[0045] 1. Preparation of composite multi-component collagen microemulsion filler

[0046] (1) Preparation of matrix solution: add injection-grade sodium chloride to the injection-grade phosphate buffer, filter and sterilize with a 0.22 μm filter to obtain a phosphate matrix solution containing 0.9% sodium chloride;

[0047] (2) Take half of the above matrix solution, add 0.5g of vitamin E, 0.06g of sodium carboxymethyl cellulose, 1.6g of soybean lecithin, and 2.0g of poloxamer into the matrix solution, heat to 60°C, and stir until completely Dissolve, filter and sterilize through a 0.22 μm filter to obtain the oil phase;

[0048] (3) Preparation of collagen microemulsion filler:

[0049] Take the remaining matrix solution to prepare collagen solutions with 40 mg / mL and 10 mg / mL of type I collagen and type III collagen (the mass ratio of the two is 4:1), add 20 mg hyaluronic acid, and use Mix it evenly with a high-pressure homogenizer, place it in a vacuum drying oven, adjust...

Embodiment 3

[0055] 1. Preparation of composite multi-component collagen common filler

[0056] (1) Preparation of matrix solution: Add injection-grade sodium chloride to commercially available injection-grade phosphate buffer, filter and sterilize with a 0.22 μm filter to obtain a sterile phosphate matrix solution containing 0.9% sodium chloride ;

[0057] (2) Collagen homogenate: Take part of the matrix solution to make collagen solutions with the contents of type I collagen and type III collagen (the mass ratio of the two is 4:1) respectively 40mg / mL and 10mg / mL, add Finally, mix it evenly with a high-pressure homogenizer;

[0058] (3) Preparation of mixed filler: add vitamin E 0.5g, sodium carboxymethylcellulose 0.06g, soybean lecithin 1.6g, and poloxamer 2.0g to the remaining matrix solution, heat to 60°C to dissolve, and then add nerve Amide 0.1g, proanthocyanidin 1.8g, vitamin C 0.5g, vancomycin 0.1g, tetracaine hydrochloride 0.3g, diclofenac 30mg, hyaluronic acid 30mg, collagen h...

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Abstract

The invention discloses a composite multi-component collagen micro-emulsion filler and a preparation method thereof. The composite multi-component collagen micro-emulsion filler is a multi-component composite micro-emulsion filler based on collagen, and a vacuum heating physical cross-linking means is adopted to physically cross-link type I collagen, type III collagen and hyaluronic acid, mechanical property of the collagen is improved, degradation time of the filler is prolonged, and good biocompatibility of the collagen is fully exerted.

Description

technical field [0001] The invention relates to a composite multi-component collagen microemulsion filler and a preparation method thereof, belonging to the field of medical cosmetology. Background technique [0002] The facial skin tissue of the human body is maintained by proteins such as collagen and elastin and an extracellular matrix containing mucopolysaccharides. When soft tissue loss occurs due to reasons such as congenital, external impact, or disease, dermal fillers containing ingredients similar to skin tissue can be injected into a specific site to restore the soft tissue or correct its shape. [0003] Currently commonly used dermal fillers are mainly composed of synthetic hydroxyapatite, polylactic acid microspheres, polymethyl methacrylate microspheres and other microspheres. These dermal fillers have a long service life and good stability. However, Studies have shown that such dermal fillers have poor biocompatibility and are prone to granuloma formation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/50A61L27/54A61L27/58
CPCA61L27/24A61L27/50A61L27/58A61L27/54A61L2400/06
Inventor 王新邢志青张平孙红张芳毅
Owner 磐升瑞祥(山东)生物工程股份有限公司
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