A functional double network hydrogel and its application

A hydrogel and double network technology, applied in the field of materials science, can solve the problems of limited application range of flexible wearable technology, loss of stretchability and original elasticity, freezing of hydrogel, etc., to achieve improved recoverability and The effect of mechanical properties, maintaining low temperature drug effect, and simple preparation method

Active Publication Date: 2022-04-08
FUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when the temperature drops below the freezing point of water, conventional hydrogels freeze and lose their stretchability and original elasticity, as well as electrical sensing functions, making them flexible under certain extreme conditions such as sub-zero temperatures. Limited range of applications such as wearable technology

Method used

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  • A functional double network hydrogel and its application
  • A functional double network hydrogel and its application
  • A functional double network hydrogel and its application

Examples

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preparation example Construction

[0032] The preparation method of the functionalized double network hydrogel of the present invention comprises the following steps:

[0033] (1) First add distilled water to two mixed powders of sodium alginate (Alg) and acrylamide (AM) to form an aqueous solution, then fully stir the solution until all the powders are dissolved to obtain solution S1;

[0034] (2) dissolving carboxylated carbon nanotube powder in solution S1, and ultrasonically dispersing in a water bath to obtain solution S2 containing carboxylated carbon nanotubes;

[0035] (3) Add N,N'-methylenebisacrylamide (MBA), tetramethylethylenediamine (TEMED), ammonium persulfate (APS) and calcium sulfate dihydrate (CaSO 4 2H 2 O) in the stirring solution S2, fully stir and mix to obtain the pre-polymerization solution S3 completely;

[0036] (4) Quickly transfer the pre-polymerization solution S3 to a glass mold, place the sealed mold under ultraviolet light, and complete the polymerization by ultraviolet light to...

Embodiment 1

[0044] (1) First add distilled water to Alg (0.01 g / mL) and AM (0.14 g / mL) mixed powders to form an aqueous solution, then stir the solution thoroughly until all the powders are dissolved to obtain solution S1;

[0045] (2) Dissolve carboxylated carbon nanotube powder (0.20 mg / mL) in solution S1, and ultrasonically disperse in a water bath to obtain solution S2 containing carboxylated carbon nanotubes;

[0046] (3) Add MBA (0.05 mg / mL), TEMED (0.10 mg / mL), APS (1.50 mg / mL) and CaSO in sequence 4 2H 2 O (13.00 mg / mL) in the stirring solution S2, the stirring time is 1 h, and the mixing is complete to obtain the pre-polymerization solution S3;

[0047] (4) Quickly transfer the pre-polymerization solution S3 into a glass mold, place the sealed mold under ultraviolet light for 1 h, and place the sample at room temperature for 3 h to complete the polymerization, and complete the polymerization by ultraviolet light to obtain ion-covalent double crosslinking Alg-Ca / PAM / CNT function...

Embodiment 2

[0049] (1) First add distilled water to Alg (0.02 g / mL) and AM (0.15 g / mL) mixed powders to form an aqueous solution, then stir the solution thoroughly until all the powders are dissolved to obtain solution S1;

[0050] (2) Dissolve carboxylated carbon nanotube powder (0.30 mg / mL) in solution S1, and ultrasonically disperse in a water bath to obtain solution S2 containing carboxylated carbon nanotubes;

[0051] (3) Add MBA (0.06 mg / mL), TEMED (0.20 mg / mL), APS (1.60 mg / mL) and CaSO in sequence 4 2H 2 O (14.00 mg / mL) in the stirring solution S2, the stirring time is 2h, and the mixing is complete to obtain the pre-polymerization solution S3;

[0052] (4) The pre-polymerization solution S3 was quickly transferred to the glass mold, and the sealed mold was placed under ultraviolet light for 2 hours, and the sample was placed at room temperature for 4 hours to complete the polymerization, and the polymerization was completed by ultraviolet light to obtain ion-covalent double cros...

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Abstract

The invention discloses a functionalized double-network hydrogel and an application thereof, belonging to the field of materials science. Calcium alginate / polyacrylamide interpenetrating double network hydrogel can effectively dissipate the loaded stress, and has excellent elasticity and flexibility; the introduction of carboxylated carbon nanotubes shows excellent mechanical properties, and also has good low temperature The electrical capability, recoverable performance, strain sensing performance, pH-responsive swelling behavior, tissue adhesion performance and sustainable drug release behavior expand its application range in flexible wearable technology and are expected to be integrated in wearable medical potential applications.

Description

technical field [0001] The invention belongs to the technical field of materials science, and in particular relates to a functionalized double network hydrogel and its low-temperature strain sensing application in flexible wearable devices and drug low-temperature delivery carriers. Background technique [0002] Hydrogels are three-dimensional network-structured polymers formed by hydrophilic polymer chains embedded in an aqueous environment. Various naturally derived and synthetic polymers can be processed into hydrogels, ranging from those formed by physical entanglement to those stabilized by covalent crosslinking. Therefore, hydrogels have emerged as a class of multifunctional soft materials due to their unique tunable physicochemical properties and structural properties. At present, hydrogels have been widely used in the fields of biotechnology and biomedicine, including artificial muscles, drug delivery, tissue engineering, etc. Due to the fact that single-network hy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L33/26C08L5/04C08K3/04C08F220/56C08F222/38A61K9/06A61K47/36A61K47/32A61K47/04G01B7/16
CPCC08J3/075C08F220/56A61K9/06A61K47/36A61K47/32A61K47/02G01B7/18C08J2333/26C08J2405/04C08K3/041C08F222/385
Inventor 张进杨黄浩曾亮丹刘子诚谢敏徐子东李玮彬钟榕峰
Owner FUZHOU UNIV
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