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A self-rolling blood vessel stent forming system and forming method

A vascular stent and collection system technology, applied in the fields of mechanical manufacturing and biomanufacturing, can solve problems such as the layered structure of difficult stents, and achieve the effects of high stent strength, high degree of automation, and improved efficiency

Active Publication Date: 2022-07-12
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these traditional methods have obtained relatively successful vascular stents or stents with a vascular network, it is difficult to achieve a hierarchical structure of the stent in the current process for preparing vascular stents.

Method used

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  • A self-rolling blood vessel stent forming system and forming method
  • A self-rolling blood vessel stent forming system and forming method
  • A self-rolling blood vessel stent forming system and forming method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] see Figure 1-Figure 2 , a layered vascular stent forming system based on electrostatic direct writing technology, including a feeding system 1, a spinning collection system 2, a three-axis motion platform 3, a power source 4, and the feeding system 1 is directly connected to the syringe of the needle; The collection system 2 is fixedly installed on the XY-axis platform of the three-axis motion platform 3 . The positive pole of the power supply 4 is connected to the metal part of the syringe needle 5 , and the negative pole is connected to the metal part of the spinning collector 6 .

Embodiment 2

[0059] Example 2 is basically the same as Example 1, the difference is only:

[0060] The feeding system 1 includes a micro-pump syringe 7 and a connecting conduit 8, and the micro-pump actuator is driven by the coupling of the micro-pump controller to push the syringe piston cylinder to extrude the spinning material;

[0061] The spinning collection system 2 is fixedly connected to the XY axis plane of the three-axis motion platform 3, the positive electrode of the power supply 4 is connected to the metal part of the syringe needle 5, and the negative electrode is connected to the metal part of the spinning collector 6, so that the syringe needle 5 and the spinning collection system are connected. A high-voltage electric field is formed between 2.

Embodiment 3

[0063] see image 3 , a film preparation method based on micro-imprint technology, comprising an air pump 9, an embossing machine 17, a temperature control system 13, the air pump 9 is directly connected with the embossing machine 17 through a conduit 11, the air pump 9 is connected with an air pressure control valve 10, and the air pressure The control valve 10 is used to adjust the feed air pressure to further control the up and down movement of the heating plate 15 ; the temperature control system 13 directly controls the surface temperature of the heating plate 15 , and the imprinting duration can be controlled by the temperature control system 13 .

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Abstract

The invention discloses a self-rolling blood vessel stent forming system and forming method. The forming system includes: a feeding system, a spinning collection system, a three-axis motion platform, a power supply, a computer control system, an embossing machine, an air pump, and a temperature control system. The forming system firstly forms the groove structure of the innermost layer of the vascular stent through the electrostatic direct writing process driven by the three-axis motion platform, and then uses the micro-imprint technology to compound the groove structure into the base film prepared by imprinting in advance. Then, through the swelling property of the self-rolling film, the base film is passively rolled into a tubular shape by using its self-rolling characteristics; finally, driven by the three-axis motion platform, the vascular stent is formed by electrospinning process. The outermost layer finally forms a three-layer vascular stent with sufficient mechanical strength.

Description

technical field [0001] The invention relates to the technical fields of mechanical manufacturing and biological manufacturing, and more particularly to a self-rolling blood vessel stent forming system and forming method based on electrostatic direct writing, electrospinning and micro-imprinting technologies. The preparation of vascular stent with ordered groove structure is realized. Background technique [0002] In recent years, the morbidity and mortality of cardiovascular disease have been increasing year by year, which has become a problem that cannot be ignored. The treatment of vascular disease is hampered by the lack of suitable autologous blood vessels. Therefore, there is an urgent need for a large number of substitutes for natural blood vessels in clinical practice, and the construction of functional tissue vascular scaffolds has broad application prospects. [0003] The inner diameter of blood vessels in the human body ranges from 5 microns to 25 mm. The blood v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/82A61L31/12A61L31/06A61L31/04A61L31/14D01D5/00
CPCA61F2/82D01D5/0007D01D5/0061A61L31/06A61L31/045A61L31/14A61F2240/001C08L67/04
Inventor 刘媛媛胡俊超王斌陆春翔简志安高闯张毅郭子龙兰伟霞刘娜岳涛
Owner SHANGHAI UNIV
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