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Traditional Chinese medicine composition and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine formula composition, can solve the problems of limited therapeutic effect, slow onset, toxicity, etc., and achieve the effects of promoting wound healing and cell migration.

Pending Publication Date: 2021-08-20
郎中堂药业(厦门)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the onset of single drug is slow, the therapeutic effect is limited, and some even have toxicity

Method used

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  • Traditional Chinese medicine composition and application thereof
  • Traditional Chinese medicine composition and application thereof
  • Traditional Chinese medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Promoting wound healing

[0033] The preparation of the traditional Chinese medicine composition gel preparation in this example: add 700g of comfrey, 100g of safflower, 100g of Galla gall, 80g of Speranthema, 60g of Bletilla striata, and 20g of Phellodendron Phellodendri in 1000mL of water, heat to boiling at 100°C for 2 hours, and concentrate the extract , mixed with conventional gel auxiliary materials according to the conventional ratio, and prepared according to the conventional method to obtain the gel preparation. It is preferred to use a water-based gel matrix formulation (for example: carbomer, glycerin, polysorbate, etc., and pH regulators and preservatives, etc. can also be added in appropriate amounts as required).

[0034] As a contrast, the preparation of the components of each single drug (comfrey, safflower, Galla gall, Sperancae sativa) is carried out with reference to the preparation of the composition gel preparation:

[0035] Add 700 g of...

Embodiment 2

[0042] Example 2: Antioxidant Activity

[0043] The preparation of the compound preparation of the traditional Chinese medicine composition of this embodiment: add 700g of comfrey, 100g of safflower, 100g of Galla gall, 80g of Speranthema, 60g of Bletilla striata, and 20g of Cortex Phellodendri in 1000mL of water, heat to boiling at 100°C for extraction for 2 hours, and concentrate the extract to powder form.

[0044] As a comparison, the preparation of comfrey, safflower and gallnut:

[0045] Add 700g of comfrey into 1000mL of water, heat to boiling at 100°C for extraction for 2 hours, and concentrate the extract to powder.

[0046] Add 100g of safflower to 1000mL of water, heat to boiling at 100°C for extraction for 2 hours, and concentrate the extract to powder.

[0047] Add 100g gallnut into 1000mL water, heat to boiling at 100°C for extraction for 2 hours, and concentrate the extract to powder.

[0048] Reactive oxygen species (ROS) mainly include hydroxyl radicals, su...

Embodiment 3

[0057] Embodiment 3: antibacterial activity

[0058] Sample preparation was as in Example 2.

[0059] Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were prepared at concentrations of 10 7 CFU / mL bacterial solution, add 15mL LB agar medium and 0.15mL bacterial solution to the petri dish, and mix quickly. After the culture medium was solidified, the Oxford cups were evenly placed in the culture dish, and 100 μL of each solution to be tested in Example 2, ampicillin (25 μg·mL- 1 ) was used as a positive control, and three parallel groups were set up for each group. Place the petri dish in a constant temperature incubator at 37°C for 24 hours to observe the results, and measure the diameter of the inhibition zone with a vernier caliper. The specific method is as follows: Judgment criteria for antibacterial effect: the diameter of the inhibition zone r>20mm is extremely sensitive, 15mm<r≤20mm is highly sensitive, 10mm<r≤15mm is moderately sensitive, and r≤10...

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Abstract

The invention discloses a traditional Chinese medicine composition and application thereof. The traditional Chinese medicine composition comprises 55-75 parts of radix lithospermi, 5-15 parts of flos carthami, 5-15 parts of galla chinensis, 5-10 parts of herba speranskiae tuberculatae, 4-10 parts of bletilla striata and 2-7 parts of cortex phellodendri. The traditional Chinese medicine composition can remarkably promote keratinocyte migration, removes DPPH free radicals, has an obvious antibacterial effect on escherichia coli, staphylococcus aureus and pseudomonas aeruginosa, and further has an effect of inhibiting NO, and it is indicated that the traditional Chinese medicine composition has potential application in the aspects of promoting wound healing, resisting oxidation, resisting bacteria, resisting inflammation, adjusting immunity and the like.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine formula composition. Background technique [0002] Traditional Chinese medicine and its active ingredients have shown obvious effects and benefits in the prevention and treatment of certain diseases in the clinic, and have been paid more and more attention by medical workers. Healthy, harmless, efficient and safe, etc., not only can solve the problems of pathogenic bacteria resistance caused by antibiotics and other chemically synthesized drugs, and the destruction of micro-ecological balance, but also meet people's needs for food safety and environmental safety. social benefits. [0003] Each type of traditional Chinese medicine has its own efficacy. At present, there are many studies on single traditional Chinese medicine and its active ingredients. However, the onset of single drug is slow, the therapeutic effe...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P17/02A61P29/00A61P31/04A61P39/06A61P9/10A61P9/00A61P31/10A61P35/00A61P37/02A61K35/64
CPCA61K36/30A61K36/286A61K35/64A61K36/47A61K36/185A61K36/898A61K36/756A61P17/02A61P29/00A61P31/04A61P39/06A61P9/10A61P9/00A61P31/10A61P35/00A61P37/02A61K2300/00Y02A50/30
Inventor 曾子晏李浩陆荣森王薛婷杨长明张卿红
Owner 郎中堂药业(厦门)有限公司
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