Composition with protection function on chemical liver injury and preparation method thereof
A chemical liver injury and protective function technology, applied in the direction of medical preparations containing active ingredients, drug combinations, digestive system, etc., can solve the problems of increased toxicity, adverse drug efficacy, enhanced toxicity, etc.
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Embodiment 1
[0045] The composition of this embodiment is composed of the following components in parts by weight: 8 parts of kudzu root, 3 parts of Hovenia dulcis, 3 parts of Schisandra chinensis, 2 parts of ginseng and 2 parts of shiitake mushroom.
[0046] The preparation method is as follows:
[0047] (1) Ginseng, shiitake mushrooms and schisandra were crushed, and 5 times the amount of water was added for steam distillation and extraction for 5 hours to obtain filtrate 1, medicinal residue 1 and volatile oil;
[0048] (2) Prepare 0.1g / mL β-cyclodextrin aqueous solution from β-cyclodextrin, slowly add volatile oil into β-cyclodextrin solution, stir magnetically at 250r / min at a constant temperature of 65°C for 1.5h, and cool , suction filtration, the precipitate was washed with 1 times the amount of water, and dried to obtain the clathrate; wherein the mass ratio of β-cyclodextrin to volatile oil was 4.5:1.
[0049] (3) Add 0.1% enzyme mixture (a mixture of β-glucosidase and ficin wit...
Embodiment 2
[0054] The composition of this embodiment is composed of the following components in parts by weight: 15 parts of kudzu root, 10 parts of Hovenia dulcis fruit, 12 parts of Schisandra chinensis, 9 parts of ginseng and 10 parts of shiitake mushroom.
[0055] The preparation method is as follows:
[0056] (4) Ginseng, mushroom and schisandra were crushed, and 8 times the amount of water was added for steam distillation and extraction for 7 hours to obtain filtrate 1, medicinal residue 1 and volatile oil;
[0057] (5) Prepare 0.1g / mL β-cyclodextrin aqueous solution from β-cyclodextrin, slowly add volatile oil into β-cyclodextrin solution, stir magnetically at 250r / min at 50°C for 2.5h, and cool , suction filtration, the precipitate was washed with 1 times the amount of water, and dried to obtain the clathrate; wherein the mass ratio of β-cyclodextrin to volatile oil was 5.5:1.
[0058] (6) Add 0.3% enzyme mixture (a mixture of β-glucosidase and ficin with a mass ratio of 10:1) to...
Embodiment 3
[0063] The composition of this embodiment is composed of the following components in parts by weight: 8 parts of kudzu root, 5 parts of Hovenia dulcis, 6 parts of Schisandra chinensis, 4 parts of ginseng and 5 parts of shiitake mushroom.
[0064] The preparation method is as follows:
[0065] (1) Ginseng, mushroom and schisandra were crushed, and 6 times the amount of water was added for steam distillation and extraction for 6 hours to obtain filtrate 1, medicinal residue 1 and volatile oil;
[0066] (2) Prepare 0.1g / mL β-cyclodextrin aqueous solution from β-cyclodextrin, slowly add volatile oil into β-cyclodextrin solution, stir magnetically at 250r / min at a constant temperature of 55°C for 2h, cool, Suction filtration, wash the precipitate with 1 times the amount of water, and dry to obtain the clathrate; wherein the mass ratio of β-cyclodextrin to volatile oil is 5:1.
[0067] (3) Add 0.2% enzyme mixture (a mixture of β-glucosidase and ficin with a mass ratio of 8:1) to th...
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