The invention discloses health-care medicinal liquor with the function of invigorating kidney and a preparation method thereof which belong to the technical field of traditional Chinese medicine. The health-care medicinal liquor is prepared from the following raw materials in weight portion: distilled spirit, and Chinese herbal medicines of aweto, ginseng, fructus schizandrae, medlar, actinolite, male silk moth, astragalus root, herba epimedii, herba cistanches, semen alli tuberosi, yam and tuckahoe. The total effective rate of the health-care medicinal liquor for renal deficiency, renal hypofunction patients, nephropathy, prostatitis, rheumatoid arthritis, cervical spondylopathy and lumbar intervertebral disc protrusion can reach over 90 percent. The health-care medicinal liquor also has auxiliary treatment and health-care function on gastritis, gastric cold, intestinal inflammation, irregular menses, adnexitis, hyperplasia of mammary glands, hypopiesis and arrhythmia. The health-care medicinal liquor has a simple concoction process, available material source, no risk in production, transportation and storage, and wide market prospect.