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Medical nickel-titanium alloy material with thermo-sensitive hydrogel coating as well as preparation method and application of medical nickel-titanium alloy material

A temperature-sensitive hydrogel and nickel-titanium alloy technology, which is applied in coatings, pharmaceutical formulations, medical science, etc., can solve the problems of poor mechanical properties and inability to use medical implant materials, so as to improve the binding force and eliminate the safety Hidden dangers, the effect of improving binding force

Active Publication Date: 2021-09-10
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its poor mechanical properties, it cannot be used alone as a medical implant material

Method used

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  • Medical nickel-titanium alloy material with thermo-sensitive hydrogel coating as well as preparation method and application of medical nickel-titanium alloy material
  • Medical nickel-titanium alloy material with thermo-sensitive hydrogel coating as well as preparation method and application of medical nickel-titanium alloy material
  • Medical nickel-titanium alloy material with thermo-sensitive hydrogel coating as well as preparation method and application of medical nickel-titanium alloy material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Materials Pretreatment: Medical Nitinol (nickel-titanium atomic ratio of 1: 1) by the wire cutting into the material The sheet-like sample, pickling, pickling, acid-wash a mass fraction of 40% HF, 60% of the mass fraction of HNO 3 Ho 2 Mixed O, pickling time is 10min; HF, HNO 3 Ho 2 O volume ratio of 1: 5:35 washing and drying, and washed with deionized water, ultrasonic cleaning 10min, after drying at room temperature standby abbreviated as "NiTi".

[0048] (2) Anodization: a concentration of 1mol / L of HNO 3 As an electrolytic solution, a step of processing a nickel-titanium alloy well as an anode, a graphite sheet as the cathode, two electrode distance is set to 40mm, oxidation 2min, after the reaction taken nitinol washed several times with deionized water at a voltage of 6V after 5min ultrasound and deionized water, drying stand, named "TiNL".

[0049] (3) thermal oxidation: the step (2) nickel-titanium alloy treated at a rate of temperature increase 5 ℃ / min ...

Embodiment 2

[0054] (1) Materials Pretreatment: Medical Nitinol (nickel-titanium atomic ratio of 1: 1) by the wire cutting into the material The sheet-like sample, pickling, pickling, acid-wash a mass fraction of 40% HF, 60% of the mass fraction of HNO 3 Ho 2 Mixed O, pickling time 5min; HF, HNO 3 Ho 2 O volume ratio of 5:10:35. Washing and drying, and washed with deionized water, ultrasonic cleaning 10min, after drying at room temperature for standby.

[0055] (2) Anodization: a concentration of 2.5mol / L of HNO 3 As an electrolytic solution, a step of processing a nickel-titanium alloy well as an anode, a graphite sheet as the cathode, two electrode distance is set to 40mm, oxidation 90min, after the reaction taken nitinol washed several times with deionized water at a voltage of 2V after 5min ultrasound and deionized water, drying stand.

[0056] (3) thermal oxidation: the step (2) nickel-titanium alloy treated at a rate of temperature increase 5 ℃ / min raised to 350 ℃, and incubated 3...

Embodiment 3

[0061] (1) Materials Pretreatment: Medical Nitinol (nickel-titanium atomic ratio of 1: 1) by the wire cutting into the material The sheet-like sample, pickling, pickling, acid-wash a mass fraction of 40% HF, 60% of the mass fraction of HNO 3 Ho 2 Mixed O, the pickling time was 5min; HF, HNO 3 Ho 2 O volume ratio of 3: 5: 60 Washing and drying, and washed with deionized water, ultrasonic cleaning 10min, after drying at room temperature for standby.

[0062] (2) Anodization: a concentration of 2.5mol / L of HNO 3 As an electrolytic solution, a step of processing a nickel-titanium alloy well as an anode, a graphite sheet as the cathode, two electrode distance is set to 40mm, oxidation 20min, after the reaction taken nitinol washed several times with deionized water at 5V after 5min ultrasound and deionized water, drying stand.

[0063](3) thermal oxidation: nitinol step (2) is treated at a rate of temperature rise 8 ℃ / min raised to 650 ℃, and incubated 2h. The sample was then so...

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Abstract

The invention relates to a medical nickel-titanium alloy material with a thermo-sensitive hydrogel coating as well as a preparation method and application of the medical nickel-titanium alloy material. The composite material comprises a nickel-titanium alloy matrix, a multi-stage porous titanium dioxide nano layer and a polyisopropylacrylamide thermo-sensitive hydrogel coating from bottom to top, the preparation method comprises the following steps of firstly, preparing a multi-stage porous titanium dioxide nano layer on the surface of the medical nickel-titanium alloy through anodic oxidation, then grafting the titanium dioxide nano layer to the surface through an initiator of a BIBAPTES solution, and then loading polyisopropylacrylamide thermo-sensitive hydrogel on the surface of a sample through chemical grafting, and obtaining the nickel-titanium alloy matrix / titanium dioxide nano layer / polyisopropylacrylamide thermo-sensitive hydrogel coating composite material. According to the medical nickel-titanium alloy material with the thermo-sensitive hydrogel coating as well as the preparation method and application of the medical nickel-titanium alloy material, the sample preparation method is simple and lower in cost, and meanwhile, the polyisopropylacrylamide thermo-sensitive hydrogel has better biocompatibility, is smooth and soft in surface and can meet the requirements of medical implantation.

Description

Technical field [0001] The present invention belongs to the technical field of surface modification of biomaterials, particularly relates to a temperature sensitive NiTi hydrogel coating titanium alloy material and its preparation method and applications, particularly, relates to a biomedical is Nitinol substrate materials, titanium dioxide nano-porous layer is prepared in a multi-stage surface of the nickel alloy by electrochemical anodic oxidation, then the temperature-sensitive hydrogel chemically grafted on the sample surface, in order to achieve selective biological effects, i.e., facilitate cell adhesion, promote endothelialization simultaneously has a strong antibacterial, antifouling properties, to avoid infection. Background technique [0002] With its unique nitinol shape memory, excellent mechanical properties and widely used in various biocompatible stent lumen. However, the high content of nickel ions to nickel alloy produced so that people doubt as long-term safety ...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/14A61L31/08A61L31/10A61L31/16C25D11/34C25F3/02C23G1/10C23F17/00
CPCA61L31/022A61L31/14A61L31/088A61L31/146A61L31/145A61L31/10A61L31/16C25D11/34C25F3/02C23G1/10C23F17/00A61L2400/12A61L2400/16A61L2300/404A61L2300/606C08L33/24
Inventor 王东辉郝雪青梁春永李宝娥王洪水
Owner HEBEI UNIV OF TECH
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