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A kind of polymer composite protective film loaded with nano antibacterial peptide, preparation method and application

An antimicrobial peptide and protective film technology, which is applied in the field of functional polypolymer composite film materials, can solve the problem of no obvious biodegradability of materials, achieve high loading efficiency and cell uptake rate, low cytotoxicity, and improve antibacterial The effect of anti-toxic effect

Active Publication Date: 2022-08-02
周建大
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the Chinese patent document CN.110527389A, 40% of nano-silica sol, 30% of polyacrylate, 10% of alcohol fat twelve, 5% of casein, 10% of trimethoprim, and 10% of dodecyldimethylbenzyl An antibacterial spray film material prepared with 2% ammonium chloride and 3% citric acid, the material has no obvious biodegradability, so it has certain defects in popularization and application

Method used

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  • A kind of polymer composite protective film loaded with nano antibacterial peptide, preparation method and application
  • A kind of polymer composite protective film loaded with nano antibacterial peptide, preparation method and application
  • A kind of polymer composite protective film loaded with nano antibacterial peptide, preparation method and application

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Embodiment 1

[0032]The present embodiment provides a method for preparing a nano-antibacterial peptide-loaded polymeric composite protective film, comprising the following steps:

[0033] S1: Preparation of polymeric composite protective film and self-assembled nanobacterial peptides

[0034] A. Pour 0.5 to 4.1 parts by mass of HACC and 0.8 to 4.1 parts by mass of PLA into 81.2 to 83.3 parts by mass of pure water, and stir at 60°C and 99 rpm. Stir thoroughly for 30 minutes to obtain a HACC / PLA multipolymer mixed solution; then pour 25.6 to 30.7 parts of the HACC / PLA multipolymer mixed solution into 74.4 to 69.3 parts of the additive solution, and fully stir at 37°C and a stirring speed of 99 rpm. Mix well for 30 minutes, pour the polymer compound solution into a clean sterilization tray, let it stand for 1 hour in a sterile fume hood, and then put it into a drying box to dry for 2 hours. Peel off the polymeric composite protective film, as attached figure 1 The additive solution contains...

Embodiment 2

[0048] The present embodiment provides a method for preparing a nano-antibacterial peptide-loaded polymeric composite protective film, comprising the following steps:

[0049] S1: Preparation of polymeric composite protective film and self-assembled nanobacterial peptides

[0050] A. Pour 4.1 parts by mass of HACC and 2.7 parts of PLA into 83.3 parts of pure water, and fully stir at 60°C and 99 rpm stirring speed for 30 minutes to obtain a HACC / PLA multipolymer mixed solution; then add 30.7 parts of HACC / Pour the PLA polymixture into 69.3 parts of the additive solution, fully stir and mix for 30 minutes at 37°C and a stirring speed of 99rpm. After the polymixture is poured into a clean sterilization dish, place it in a sterile fume hood. After standing and casting for 1 hour, put it into a drying box to dry for 2 hours. After the drying is completed, gently peel off the dried material to obtain a polymeric composite protective film; the additive solution contains the followin...

Embodiment 3

[0061] A preparation method of a nano-antibacterial peptide-loaded polymer composite protective film, comprising the following steps:

[0062] S1: Preparation of polymeric composite protective film and self-assembled nanobacterial peptides

[0063] A. Pour 3.8 parts by mass of HACC and 2.9 parts of PLA into 83.3 parts of pure water, and fully stir for 30 minutes at 60°C and 99 rpm stirring speed to obtain a HACC / PLA multipolymer mixed solution; then add 30.7 parts of HACC / Pour the PLA polymixture into 69.3 parts of the additive solution, fully stir and mix for 30 minutes at 37°C and a stirring speed of 99rpm. After the polymixture is poured into a clean sterilization dish, place it in a sterile fume hood. After standing and casting for 1 hour, put it into a drying box to dry for 2 hours. After the drying is completed, gently peel off the dried material to obtain a polymeric composite protective film; the additive solution contains the following components by mass: 0.8-1.8 par...

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Abstract

The invention relates to the technical field of functional polymer polymer composite film materials, and discloses a preparation method of a nanometer antimicrobial peptide-loaded polymer composite protective film; and also discloses a nanometer antimicrobial peptide-loaded HACC / PLA polymer composite protective film; Apps are also exposed. The protective film of the invention has the functions of high-efficiency protection, good biocompatibility, environmental protection and degradability, etc. The invention combines the loaded nano antibacterial peptide with the HACC / PLA polymer composite protective film, which can greatly improve the antibacterial resistance of the existing protective film. Poisonous effect and good biocompatibility, the protective film of the present invention has become a major breakthrough of new protective biological materials, has a wide range of applications, and has huge application value and broad market prospects in daily life and medical care.

Description

technical field [0001] The invention relates to the technical field of functional polymer polymer composite membrane materials, in particular to a polymer composite protective membrane loaded with nanometer antimicrobial peptides, a preparation method and an application. Background technique [0002] With the continuous development of bioengineering and tissue engineering, more and more "medicine-engineering" products have entered human daily life, especially in the field of medical and health care. For example, biomedical materials, polymer composite tissue materials, and bioimplantable materials are gradually being used in the medical and health industry. At the same time, minimally invasive interventional therapy, invasive Modern diagnosis and treatment methods also play an important role in medical services. However, the use of these materials also increases the risk of medical infection, and the corresponding cross-infection and occupational infection also follow. Ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/46A61L15/42A61L15/28A61L15/20A61L15/26A61L31/08A61L31/10A61L31/16A61L31/14A01N37/46A01N25/06A01N25/04A01P1/00
CPCA61L15/32A61L15/46A61L15/425A61L15/42A61L15/28A61L15/20A61L15/26A61L31/08A61L31/10A61L31/16A61L31/146A61L31/14A01N37/46A01N25/06A01N25/04A61L2400/12A61L2300/208A61L2300/232A61L2300/252A61L2300/404A61L2300/45A61L2300/606C08L5/08C08L67/04C08L89/00
Inventor 周建大吴先睿谢慧清颜宇李泽楠李哲琳史可
Owner 周建大
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