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Atomized oyster and ginseng composite peptide as well as preparation method and application thereof

A compound peptide and ginseng technology, applied in application, drug combination, pharmaceutical formula, etc., can solve the problems of oyster chronic obstructive pulmonary disease, low oral bioavailability and high cost of macromolecular peptide components, and achieve Improve lung function and quality of life, increase bioavailability and efficacy, reduce price and possible efficacy

Inactive Publication Date: 2021-10-22
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, ginseng or oyster products are mostly administered orally, but the oral bioavailability of macromolecular peptide components is low, and injection administration is expensive, inconvenient to take, and has relatively large side effects
According to literature search, so far, no reports of oysters being used to treat chronic obstructive pulmonary disease have been retrieved, while reports on ginseng treating chronic obstructive pulmonary disease have only seen saponins, and no macromolecular water-soluble components have been found to prevent and treat chronic obstructive pulmonary disease. Reports on chronic lung disease

Method used

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  • Atomized oyster and ginseng composite peptide as well as preparation method and application thereof
  • Atomized oyster and ginseng composite peptide as well as preparation method and application thereof
  • Atomized oyster and ginseng composite peptide as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Weigh 95 portions of freshly shelled oyster meat, wash with distilled water, and set aside; weigh 5 portions of dried ginseng, crush them into coarse powder, add water to soak, and set aside; combine ginseng coarse powder and oyster meat, decoct and extract with 12 times the volume of distilled water , filtered to take the filtrate, merged, concentrated, added 85% ethanol while stirring, allowed to stand for 24 hours, filtered to take the precipitate, and obtained the water-soluble crude extract of oyster ginseng;

[0046] The water-soluble crude extract of oyster ginseng is enzymatically hydrolyzed with pepsin, the substrate concentration is 10%, the amount of enzyme added is 5%, the pH of the enzymolysis solution is 5.5, the enzymolysis temperature is 55°C, the enzymolysis time is 6 hours, and then 100°C Inactivate for 10 minutes, centrifuge the enzymatic hydrolyzate, take the filtrate, decolorize it with activated carbon, and spray-dry the filtrate to obtain the oyste...

Embodiment 2

[0048] Weigh 50 parts of fresh shelled oyster meat, wash with distilled water, and set aside; weigh 50 parts of dried ginseng, crush it into coarse powder, add water to soak, and set aside; combine ginseng coarse powder and oyster meat, decoct and extract with 20 times distilled water, filter and take After the filtrates were combined and concentrated, 75% ethanol was added while stirring, and left to stand for 36 hours, and the precipitate was filtered to obtain a water-soluble crude extract of oyster ginseng;

[0049] The water-soluble crude extract of oyster ginseng is enzymatically hydrolyzed with pepsin:papain=5:5 compound enzyme, the substrate concentration is 1%, the amount of enzyme added is 1%, the pH of the enzymolysis solution is 5.0, and the enzymolysis temperature is 45°C. The enzymolysis time was 8 hours, followed by inactivation at 100°C for 10 minutes, the enzymolysis solution was centrifuged, the filtrate was taken, decolorized with activated carbon, and the fi...

Embodiment 3

[0051]Weigh 5 parts of fresh shelled oyster meat, wash with distilled water, and set aside; weigh 95 parts of dried ginseng, crush it into coarse powder, add water to soak, and set aside; combine ginseng coarse powder and oyster meat, decoct and extract with 16 times distilled water, filter and take After the filtrates were combined and concentrated, 95% ethanol was added while stirring, and left to stand for 48 hours, and the precipitate was filtered to obtain a water-soluble crude extract of oyster ginseng;

[0052] The water-soluble crude extract of oyster ginseng is enzymolyzed with trypsin: flavor protease = 1:9 compound enzyme, the substrate concentration is 20%, the amount of enzyme added is 10%, the pH of the enzymolysis solution is 6.5, and the enzymolysis temperature is 65°C. The enzymolysis time was 3 hours, followed by inactivation at 100°C for 10 minutes, the enzymolysis solution was centrifuged, the filtrate was taken, decolorized with activated carbon, and the fi...

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Abstract

The invention relates to atomized oyster and ginseng composite peptide and a preparation method and an application thereof, and belongs to the field of biological medicine and health food. The preparation method comprises the following steps: mixing 5-95% of oyster meat and 5-95% of coarse ginseng powder, decocting and extracting with water, mixing filtrate, concentrating, adding ethanol with the concentration of 75-95%, standing, filtering, taking precipitate, carrying out enzymolysis on the obtained oyster and ginseng water-soluble crude extract, centrifuging enzymatic hydrolysate, taking filtrate, carrying out spray drying, and preparing the oyster and ginseng composite peptide into spray, aerosol or powder inhalation. The product has the advantages of having the efficacy of preventing and treating chronic obstructive pulmonary diseases, being capable of being used as an auxiliary treatment medicine for lung health care and lung diseases such as pneumonia, being beneficial to enhancing the immune function of patients with lung diseases, improving the lung function and life quality of the patients, improving the bioavailability and effect, reducing the price and possible toxic reaction, and by adopting a spraying mode, the oral liquid is taken by mouth or nose, and has certain popularization and application values.

Description

technical field [0001] The invention belongs to the fields of biomedicine and health food, and in particular relates to an atomized oyster ginseng compound peptide and its preparation method and application. Background technique [0002] Oyster, also known as oyster, sea oyster, oyster yellow, etc., is cold in nature and cool in taste. Its meat is delicious and delicious, and it has high nutritional and medicinal value. Modern pharmacological studies have shown that oysters have the functions of enhancing immunity, anti-fatigue, anti-virus, protecting the liver, lowering blood sugar, anti-tumor, anti-oxidation, and antibacterial. Oysters, especially oyster meat, are rich in protein and carbohydrates, as well as a variety of amino acids, glycogen, and active trace elements. Ginseng is the dried root and rhizome of Panax ginseng C.A.Mey., a plant of the Araliaceae family. . The material basis for ginseng to exert multiple pharmacological effects mainly includes components s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K35/618A61K9/12A61P11/00A23L33/18A23L33/185
CPCA61K35/618A61K36/258A61K9/12A61K9/0043A61K9/0053A61P11/00A23L33/18A23L33/185A61K2236/331A61K2236/53A61K2236/51A61K2236/19A23V2002/00A61K2300/00A23V2200/314A23V2250/55A23V2250/548
Inventor 张庆贺陈长宝俞萍王恩鹏李琼张涛王欢陈雪刘芳馨
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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