Moisture-proof mite allergen soluble microneedle

Abstract

The invention discloses a moisture-proof mite allergen soluble microneedle. The moisture-proof mite allergen soluble microneedle comprises a needle body and a backing, wherein the needle body comprises mite allergen and a composite matrix material, the composite matrix material is a mixture of a methyl vinyl ether-maleic anhydride copolymer and polyvinyl alcohol, and the content ratio of the methyl vinyl ether-maleic anhydride copolymer to the polyvinyl alcohol is (1:1.5)-(2:1). According to the moisture-proof mite allergen soluble microneedle, by screening the appropriate matrix material type and content (Gantrez S-97+PVA) and the appropriate drug loading ratio, the prepared mite allergen soluble microneedle can still have good mechanical strength under a high-humidity condition, is easy to pierce into the skin for drug administration, and does not affect the activity of the mite allergen.

Description

technical field [0001] The invention relates to the technical field of administration of mite allergens, in particular to a moisture-resistant soluble microneedle for mite allergens. Background technique [0002] The incidence of allergies is very high, and literature reports that about one-third of people suffer from allergic diseases in their lifetime. According to the statistics of my country's Beijing area, the incidence of allergies in the general population is about 15%. Allergic disease is even as high as 50% in parts of the Pacific Ocean. Since entering the 21st century, the disease has become one of the most common global diseases. According to the data of the World Health Organization, 22% to 25% of people in the world suffer from allergic diseases at present, and the rate of increase is 23 times every 10 years. Therefore, allergy and anti-allergy are unavoidable serious problems faced by modern people. Antigenic substances that cause allergic reactions are cal...

AI Technical Summary

Problems solved by technology

[0006] For example, the Chinese patent with the publication number CN109715075A provides a preparation idea of ​​loading microneedles with a composition containing at least one allergen, and selects a specific matrix material hyaluronic acid for research, but the technical solution has shortcomings The reason is that this patent focuses on the changes in the preparation process of microneedles loaded with allergens, and does not examine the factors affecting humidity, different allergens, and different matrix materials, nor does it discuss any specific allergens (such as mite allergens) ) into dissolvable microneedles for formulation screening

Therefore, when the mite allergen is loaded into the soluble microneedles under specific humidity conditions, the difference in the mechanical properties of the soluble microneedles caused by the change of the formulation cannot be known from this patent

[0007] For example, the Japanese patent with the publication number JP2014156433A only generally introduced the possibility of allergen loading into microneedles, focusing on the change of microneedle structure, but the disadvantage of this technical solution is that there is no specific embodiment Prove that different matrix materials have different mechanical properties for the development of mite allergen soluble microneedles, and it is impossible to judge whether they are resistant to moisture

The conclusion of this document is very different from the common knowledge that "the greater the relative humidity, the worse the mechanical properties", but the technical shortcomings of this document are: ①Due to the difference in climate and region in daily life, the relative humidity of the air is also very different , while the literature only examined the relative humidity conditions of 43%RH and 86%RH, it is not enough to predict that the mechanical properties of Gantrez S-97 microneedles also meet the requirements of the formulation under other humidity conditions; ②Further, due to the mite allergen The physical and chemical properties are very different from those of vitamin K, so when using Gantrez S-97 drug-loaded mite allergen to make soluble microneedles, does it still comply with the law that "the mechanical properties of microneedles at 86% relative humidity are better than those at 43% relative humidity" , also unknown

[0010] It can be seen that under different humidity conditions, the selection of soluble microneedles made of different materials loaded with different drugs has different effects on the mechanical properties of the microneedles, which has brought great implications for the selection of matrix materials when developing soluble microneedles for mite allergens. uncertainty

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