Method for preparing beta-aminopropionic acid with high selectivity

Abstract

The invention discloses a method for preparing beta-aminopropionic acid from acrylic acid. The method comprises the step that: in a tank reactor, acrylic acid and ammonia water react in the presence of a catalyst and a ligand, and then reaction liquid is subjected to deamination, concentration and crystallization treatment to prepare beta-aminopropionic acid, wherein the catalyst is a transition metal inorganic salt, and the ligand is a pyridine ligand. The method has the advantages of good product selectivity, high yield, convenience in purification, mild process conditions and the like. Experiments show that: with the catalyst and the ligand introduced, the conversion rate of the acrylic acid is greater than 99%, the yield of the single-pass product of the reaction is greatly improved to 82%, the difficulty of later purification is greatly reduced, a mother liquor can be recycled, and the recycling yield is greater than 95%.

Description

technical field

[0001] The invention belongs to the technical field of chemistry, and in particular relates to a preparation method of β-alanine. Background technique

[0002] β-alanine, as the only β-type amino acid in nature, is mainly used as a key intermediate in the synthesis of calcium pantothenate (vitamin B5). In addition, it is also widely used in medicine, food and other fields, and has a good market prospect. At present, the methods for producing β-alanine mainly include acrylonitrile ammoniation hydrolysis, enzymatic method and acrylic acid ammoniation method. Among them, the route of the acrylonitrile method is relatively long, and after hydrolysis, a large amount of inorganic salts are produced, so purification is relatively difficult. The enzymatic method mainly uses L-aspartic acid as a raw material, which is catalyzed by L-aspartic acid decarboxylase, and the production cost is relatively high, and it is accompanied by the generation of a large amount of wa...