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Fluorescent magnetic composite nanofiber and preparation method and application thereof

A magnetic composite nanometer and magnetic nanoparticle technology, applied in nanotechnology, nanotechnology, nano-optics and other directions, can solve problems such as single function, and achieve the effects of simple preparation process, strong magnetic responsiveness and controllable magnetic content

Active Publication Date: 2021-11-12
HONGKUI BIOLOGICAL CHINA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the function of the two is single, such as quantum dots for fluorescent labeling and magnetic particles for magnetic separation

Method used

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  • Fluorescent magnetic composite nanofiber and preparation method and application thereof
  • Fluorescent magnetic composite nanofiber and preparation method and application thereof
  • Fluorescent magnetic composite nanofiber and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Prepare fluorescent magnetic composite nanofibers, the steps are as follows:

[0056] (1) Preparation of phenylboronic acid-modified magnetic Fe 3 o 4 nanoparticles

[0057] (a) Amination modification

[0058] Chitosan powder was ultrasonically dispersed in 2% acetic acid solution to prepare 5 mL of 0.005 g / mL chitosan gel solution. Weigh 200mg magnetic Fe 3 o 4 The nanoparticles are dissolved in the above-mentioned chitosan gel solution, nitrogen gas is passed through to deoxidize, and an ultrasonic cleaning machine is used for ultrasonication to form a uniformly dispersed magnetic particle chitosan gel solution. The magnetic particle chitosan gel solution is added dropwise in the microemulsion system (paraffin oil 80g, Span80 10g and ethanol 5g), emulsified for 30min, then 0.5mL concentration is that 5% glyoxal solution is added to the above-mentioned microemulsion system , the temperature of the reaction system was adjusted to 30°C, and the reaction was carried...

Embodiment 2

[0070] Prepare fluorescent magnetic composite nanofibers, the steps are as follows:

[0071] (1) Preparation of phenylboronic acid-modified magnetic CoFe 2 o 4 nanoparticles

[0072] (a) Amination modification

[0073] The carboxymethyl chitosan powder was ultrasonically dispersed in an aqueous solution to prepare 5 mL of a 0.01 g / mL carboxymethyl chitosan gel solution. Weigh 300mg magnetic CoFe 2 o 4 The nanoparticles are dissolved in the above-mentioned carboxymethyl chitosan gel solution, nitrogen gas is passed through to deoxygenate, and an ultrasonic cleaning machine is used for ultrasonication to form a uniformly dispersed magnetic particle carboxymethyl chitosan gel solution. The magnetic particle carboxymethyl chitosan gel solution is added dropwise in the microemulsion system ((paraffin oil 85g, Span80 5g and ethanol 5g), emulsified for 30min, then 2mL concentration is that 10% glutaraldehyde solution is added to the above-mentioned In the microemulsion system, ...

Embodiment 3

[0086] Prepare fluorescent magnetic composite nanofibers, the steps are as follows:

[0087] (1) Preparation of phenylboronic acid-modified magnetic Co 3 o 4 nanoparticles

[0088] (a) Amination modification

[0089] The carboxymethyl chitosan powder was ultrasonically dispersed in an aqueous solution to prepare 5 mL of a 0.05 g / mL carboxymethyl chitosan gel solution. Weigh 500mg magnetic Co 3 o 4 The nanoparticles are dissolved in the above-mentioned carboxymethyl chitosan gel solution, nitrogen gas is passed through to deoxygenate, and an ultrasonic cleaning machine is used for ultrasonication to form a uniformly dispersed magnetic particle carboxymethyl chitosan gel solution. The magnetic particle carboxymethyl chitosan gel solution is added dropwise in the microemulsion system (paraffin oil 80g, Span80 10g and ethanol 10g), emulsified for 60min, and then 3mL concentration is that 15% formaldehyde solution is added to the above-mentioned microemulsion system In , the ...

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Abstract

The invention discloses a fluorescent magnetic composite nanofiber and a preparation method and application thereof, and belongs to the technical field of nanofiber preparation. The fluorescent magnetic composite nanofiber is prepared by carrying out electrostatic spinning on phenylboronic acid modified magnetic nanoparticles and phenylboronic acid modified core-shell structure quantum dots in a spinning polymer solution. The fluorescent magnetic composite nanofiber has dual functions of magnetic separation and fluorescent tracing, and can be used for selectively identifying, separating, enriching and detecting glycoprotein.

Description

technical field [0001] The invention belongs to the technical field of nanofiber preparation, and in particular relates to a fluorescent magnetic composite nanofiber, a preparation method and application thereof. Background technique [0002] Quantum dots and magnetic nanoparticles have shown obvious advantages in many fields, especially in the field of biomedicine. However, the functions of both are single, such as quantum dots for fluorescent labeling and magnetic particles for magnetic separation. If the two functions of separation and labeling are integrated to form fluorescent magnetic nanoparticles, the product can have dual functions of magnetic separation and fluorescent tracking, and its performance and application range will far exceed that of single-function nanoparticles. It can realize the detection and separation of biomolecules, and can also realize multiple modes of imaging, such as fluorescence imaging, magnetic resonance imaging (MRI) and laser confocal mi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30G01N21/64C09K11/02C09K11/88B82Y20/00B82Y30/00B82Y40/00D01F1/10D01F6/50D01F9/00D01F9/04
CPCB01J20/26B01J20/22B01J20/262B01J20/261B01J20/24B01J20/28009B01J20/28023B01J20/06B01J20/02G01N21/6428D01F1/10D01F9/00D01F6/50D01F9/04C09K11/02C09K11/883B82Y20/00B82Y30/00B82Y40/00B01J2220/4806B01J2220/4812B01J2220/46
Inventor 丁永玲孙华东庞来学张京楼
Owner HONGKUI BIOLOGICAL CHINA CO LTD
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