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Preparation method of porous polyester microspheres, porous polyester microspheres and application of porous polyester microspheres

A porous polyester and polyester technology, applied in the application of porous polyester microspheres, the preparation of porous polyester microspheres, the field of porous polyester microspheres, can solve the problems of slow degradation, difficult degradation, environmental pollution, etc., and achieve drug loading Strong capacity, large specific surface area, and good loading performance

Pending Publication Date: 2021-11-23
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the environmental factors in natural water bodies, especially seawater, are very different from those in soil and composting environments, especially the temperature in seawater, and the types and quantities of specific microorganisms are significantly lower than those in soil and composting. Degradation is often slow in water bodies, or even difficult to degrade
Therefore, when biodegradable polyester materials exist in water bodies, especially seawater, there is still a risk of potential environmental pollution

Method used

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  • Preparation method of porous polyester microspheres, porous polyester microspheres and application of porous polyester microspheres
  • Preparation method of porous polyester microspheres, porous polyester microspheres and application of porous polyester microspheres
  • Preparation method of porous polyester microspheres, porous polyester microspheres and application of porous polyester microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 20 g of poly succinate-lactate copolyester (PBSL), 10G polyvinylpyrrolidone (PVP) and 150 ml of tetrahydrofuran were added to 64 ° C, and the material was stirred so dissolved, then 60 ml of mixing. Ethanol was stirred for 2min, stop heating, standing, precipitating powder, filtration, washing, drying, gave PBSL micropowder; figure 1 For this reason, the obtained polyamide porous microsphere scanning electron microscope, which can be seen from the figure, the microspheres are equal to 30 μm, and the surface aperture is uniform. The microsphere BET specific surface area is 24m more than the surface instrument 2 / g, the maximum aperture is 1 μm. The laser particle size gauge was measured by the microsphere particle size distribution coefficient of 0.98.

Embodiment 2

[0050] At room temperature, 20 g of dikaric alkanol ester-co-glycolic acid (PBSG) polyester raw material, 10 g of polyvinylpyrrolidone (PVP) and 150 ml of tetrahydrofuran were added to 64 ° C, and the mixture was stirred for 2 h Dissolved, then 60 mL of ethanol was stirred for 2min, stop heating, standing, precipitating powder, filtration, washing, dried to give porous polyester microsphere powder; the obtained porous polyester microspheres were 275 μm, and the surface aperture was uniform. The microsphere bet specific surface area is 18m than the surface instrument 2 / g, the maximum aperture is 1.6 μm. The laser particle size gauge was measured by the microsphere particle size distribution coefficient of 0.94.

[0051] Among them, butadic acid hysin-co-methanol (PBSG) polyester raw materials can be synthesized by the following methods: 1,4-butanedate 10 mol, 1,4-butahydrol (excess) 15 mol, 160-180 After the esterification of ° C for 2 h, the catalyst titanate 7.0 g, 200-230 ° C ...

Embodiment 3

[0054] Example 2 was replaced with 1,4-butyric acid and 1,4-butylene glycol to be a terephthalate, and the copolyester feedstock was obtained by the same preparation method as in Example 2. The structure is as shown in the following formula (2):

[0055]

[0056] At room temperature, 20 g of a copolyester raw material A, 10G polyvinylpyrrolidone (PVP) and 150 ml of tetrahydrofuran were added to 64 ° C, stirred for 2 h, so that the material was sufficiently dissolved, then 60 ml of ethanol was stirred for 2 min, stop heating, quiet To give a porous polyester microsphere powder; the obtained porous polyester microspheres were obtained by 94 μm, and the surface aperture was uniform. The microsphere BET specific surface area is 53m than the surface instrument 2 / g, the maximum aperture is 1.4 μm. The laser particle size gauge was measured by the microsphere particle size distribution coefficient of 0.9.

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Abstract

The invention provides a preparation method of porous polyester microspheres, which comprises the steps of S1, at an initial reaction temperature, adding copolyester and a dispersing agent into a good solvent of the copolyester and the dispersing agent, stirring, dissolving, and heating to obtain a homogeneous solution; S2, adding a poor solvent of copolyester into the homogeneous solution, stirring until the materials are fully mixed, standing, slowly cooling, and separating out a precipitate; and S3, filtering, washing and drying the precipitant to obtain porous polyester microspheres, wherein a molecular chain segment of the copolyester comprises a chain segment of the difficult-to-hydrolyze polyester and a chain segment of the easy-to-hydrolyze polyester, and the polyester is an irregular copolymer or a segmented copolymer composed of a segment of the difficult-to-hydrolyze polyester and a segment of the easy-to-hydrolyze polyester. The prepared porous polyester microspheres can be applied to the fields of cosmetics, medicine slow release, coatings, toy bullets and the like, and the porous polyester microspheres have good biodegradability in seawater.

Description

Technical field [0001] The present disclosure relates to the field of polymer materials, and more particularly to the preparation method of porous polyester microspheres, and the polyester microspheres prepared therefrom, and the application of the porous microspheres. Background technique [0002] Polymer microspheres are materials formed from polymer materials or polymer composites, spherical or other geometries. Special functionality from microsphere materials has gradually extended its application field (coating, paper surface processing, adhesive, plastic additives, building materials and other fields) (medical and medical, biochemical fields and Electronic information, etc. [0003] Biodegradable plastics are a class of aliphatic polyesters or copolyes. Not only is the heat, mechanical properties and processability of general plastics, but relative to olefins, amide polymer materials, ester bonds are more susceptible to water, oxygen, microbial action, have a molecular chai...

Claims

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Application Information

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IPC IPC(8): C08J9/28C08L67/00C08L39/06
CPCC08J9/28C08J2367/00C08J2439/06C08J2201/0502
Inventor 王格侠季君晖卢波甄志超李飞
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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