Modified gold nanorod photo-thermal bacteriostatic preparation as well as preparation method and application thereof
A gold nanorod and photothermal technology, which is applied in botany equipment and methods, applications, nanotechnology, etc., can solve the problems of low photothermal conversion efficiency of gold nanorods, high toxicity of gold nanorods, poor biological safety, etc., and achieve Improve light-to-heat conversion efficiency, broaden the scope of antibacterial use, and fast synthesis
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Embodiment 1
[0040] A modified gold nanorod photothermal antibacterial preparation and a preparation method thereof, the steps are as follows:
[0041] At room temperature, add 1mL of ultrapure water to a 10mL centrifuge tube and place it on an oscillator for oscillation. The oscillation frequency of the oscillator is 600rpm / min. Add 1mL of gold nanorod sol with a molar concentration of 200ppm to the centrifuge tube in turn. , 500uL MnSO with a concentration of 1mg / mL 4 aqueous solution, 500uL proanthocyanidin aqueous solution with a molar concentration of 4mg / mL, the time interval is 1min, and finally, 2mL Tris-HCl buffer solution (pH8.0) with a concentration of 20mM is added thereto, and the reaction is shaken at room temperature for 5min. After the reaction, remove the centrifuge tube, centrifuge at 8000rpm at 25°C for 5min, remove the supernatant, add 5mL ultrapure water to redisperse, and obtain the modified gold nanorod photothermal antibacterial preparation; the prepared Antibacter...
Embodiment 2
[0049] A modified gold nanorod photothermal antibacterial preparation and a preparation method thereof, the steps are as follows:
[0050] At room temperature, add 2mL of ultrapure water to a 10mL centrifuge tube and place it on an oscillator for oscillation. The oscillation frequency of the oscillator is 700rpm / min. Add 1mL of gold nanorod sol with a molar concentration of 200ppm to this centrifuge tube in turn. , 500uL of FeCl with a concentration of 1mg / mL 3 Aqueous solution, 500uL tannic acid aqueous solution with a molar concentration of 4mg / mL, the time interval is 1min, and finally, 1mL Tris-HCl buffer (pH8.0) with a concentration of 20mM is added thereto, and the reaction is shaken at room temperature for 5min. After the reaction, remove the centrifuge tube, centrifuge at 9000rpm at 25°C for 7 minutes, remove the supernatant, add 5mL ultrapure water to redisperse, and obtain the modified gold nanorod photothermal antibacterial preparation; the prepared Antibacterial p...
Embodiment 3
[0053] A modified gold nanorod photothermal antibacterial preparation and a preparation method thereof, the steps are as follows:
[0054] At room temperature, add 1.4mL of ultrapure water to a 10mL centrifuge tube and place it on an oscillator for oscillation. The oscillation frequency of the oscillator is 800rpm / min. Add 1mL of gold nanorods with a molar concentration of 200ppm to the centrifuge tube in turn. Sol, 300uL of CuCl with a concentration of 1mg / mL 2 Aqueous solution, 300uL of epigallocatechin gallate aqueous solution with a molar concentration of 4mg / mL, the time interval is 1min, and finally, 1mL of Tris-HCl buffer solution (pH8.0) with a concentration of 20mM is added thereto, and shaken at room temperature React for 5 minutes. After the reaction, remove the centrifuge tube, centrifuge at 10,000rpm at 20°C for 5min, remove the supernatant, add 5mL of ultrapure water to redisperse, and obtain the modified gold nanorod photothermal antibacterial preparation; the ...
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