Novel veterinary uterus injectant as well as preparation method and application thereof

An injection, uterus technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of neglect, endometrial damage, inability to take into account the repair of uterine epidermis, etc. To achieve the effect of accelerating cell repair, promoting proliferation, and speeding up the recovery of healthy physique

Active Publication Date: 2021-12-28
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the uterine injections currently on the market take the bactericidal effect as the main purpose, and cannot take into account the repair of the uterine epidermis and tissue. They only focus on "treatment" and ignore "prevention". Injured cows, abortion, dystocia, retained placenta and irregular artificial insemination will provide opportunities for pathogenic bacteria to invade, and pathogenic bacteria are likely to accumulate in large numbers during this period, causing related diseases. Therefore, the injection takes into account the uterus Repair of epidermis and tissue is necessary

Method used

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  • Novel veterinary uterus injectant as well as preparation method and application thereof
  • Novel veterinary uterus injectant as well as preparation method and application thereof
  • Novel veterinary uterus injectant as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A new veterinary uterine injection, calculated by 100ml, consists of the following components: Rifaximin self-microemulsion 5g, adsorption carrier 1g, growth repair factor (oligopeptide-1 / blue copper peptide: collagen peptide: transparent Sodium hyaluronate=0.3:1:3) 4.3g, water-soluble silk fibroin 10g, GantrezAN 0.5g, the balance is water for injection;

[0041] Its preparation method comprises the following steps:

[0042] (1) Weigh 9.6g of polyoxyethylene ether hydrogenated castor oil (Cremophor RH 40) and 48g of diethylene glycol monoethyl ether (Transcutol P) and place them in a vortex mixer for vortex mixing, then add caprylic acid Add 38.4 g of capric monoglyceride (Capmul MCM) into the above mixture, vortex and mix to obtain a blank self-microemulsion, and dissolve 4 g of rifaximin into the blank self-microemulsion to obtain a rifaxime Mingzi microemulsion;

[0043] (2) Put calcium silicate (FLORITE PS-10) and hydrophilic fumed silica (AEROSIL 380) in a square...

Embodiment 2

[0049] Same as Example 1, the difference is that it does not contain adsorbents. In the process, rifaximin self-microemulsion and growth repair factor are directly added to the original step (5) to make rifaximin uterine injection. The specific steps are as follows:

[0050] A novel veterinary uterine injection, in 100ml, consists of the following components: rifaximin self-microemulsion 5g, growth repair factor (oligopeptide-1 / blue copper peptide: collagen peptide: sodium hyaluronate= 0.3:1:3) 4.3g, water-soluble silk fibroin 10g, GantrezAN 0.5g, the balance is water for injection;

[0051] Its preparation method comprises the following steps:

[0052] (1) Weigh 9.6g of polyoxyethylene ether hydrogenated castor oil (Cremophor RH 40) and 48g of diethylene glycol monoethyl ether (Transcutol P) and place them in a vortex mixer for vortex mixing, then add caprylic acid Add 38.4 g of capric monoglyceride (Capmul MCM) into the above mixture, vortex and mix to obtain a blank self-m...

Embodiment 3

[0056] Same as Example 1, the difference is that the adsorption carrier is a hydrophilic fumed silica, and the specific steps are as follows:

[0057] A new veterinary uterine injection, calculated by 100ml, consists of the following components: rifaximin self-microemulsion 5g, hydrophilic fumed silica 1g, growth repair factor (oligopeptide-1 / blue copper peptide: Collagen peptide: sodium hyaluronate = 0.3:1:3) 4.3g, water-soluble silk fibroin 10g, GantrezAN 0.5g, the balance is water for injection;

[0058] Its preparation method comprises the following steps:

[0059] (1) Weigh 9.6g of polyoxyethylene ether hydrogenated castor oil (Cremophor RH 40) and 48g of diethylene glycol monoethyl ether (Transcutol P) and place them in a vortex mixer for vortex mixing, then add caprylic acid Add 38.4 g of capric monoglyceride (Capmul MCM) into the above mixture, vortex and mix to obtain a blank self-microemulsion, and dissolve 4 g of rifaximin into the blank self-microemulsion to obtai...

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Abstract

The invention provides a preparation method of a novel veterinary uterus injectant, which belongs to the field of veterinary preparations, and comprises the following steps: respectively mixing an adsorption carrier with rifaximin self-microemulsion and a growth repair factor to prepare self-microemulsion drug-loaded particles and growth repair factor drug-loaded particles; and mixing a first matrix, a second matrix and water for injection to prepare an injection matrix, mixing the injection matrix with the self-microemulsion drug-loaded particles and the growth repair factor drug-loaded particles, and freeze-drying to prepare the uterus injectant, by utilizing the cell growth promoting effect of the growth repair factor and the cell proliferation microenvironment provided by the gel matrix, the repair of endometrial epidermis cells is accelerated, the regeneration of damaged tissues is promoted, and a protective barrier is established, so that new infection in the uterus can be prevented, and the morbidity of endometritis is reduced.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a novel uterine injection for veterinary use and its preparation method and application. Background technique [0002] Dairy cow endometritis is a relatively common disease in the process of raising cattle. It has a high morbidity rate but a low case fatality rate, often in a chronic process. The disease will not only seriously reduce the reproductive ability of the sick cow, but also reduce the milk production to a certain extent, and even lose the ability to lactate. If the symptoms are severe, it will cause infertility, and even can only be eliminated. Cause other diseases, such as metritis and so on. In recent years, with the continuous expansion of dairy cow breeding scale and the widespread application of artificial insemination technology, the incidence of this disease has been on the rise, which seriously damages the economic benefits of dairy cow breeding ind...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/439A61K31/728A61K38/18A61K38/39A61K47/02A61K47/04A61K47/32A61K47/38A61K47/42A61P15/00A61P31/04
CPCA61K9/0024A61K9/06A61K31/439A61K38/1808A61K38/39A61K31/728A61K47/02A61K47/38A61K47/42A61K47/32A61P15/00A61P31/04A61K2300/00
Inventor 辜质纯周淑贞陶映娴元晓琪谢志恒
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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