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Preparation method of pH-responsive zanthoxylum seed antibacterial peptide microcapsule

A technology of Zanthoxylum bungeanum and antimicrobial peptides, which is applied in the field of preparation of pH-responsive Zanthoxylum bungeanum antimicrobial peptide microcapsules, can solve problems such as the influence of antimicrobial peptide activity, and achieve the effects of prolonging antibacterial time, low cost, and extending food shelf life

Pending Publication Date: 2022-01-04
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Food spoilage is mainly caused by the growth and reproduction of microorganisms. Although antimicrobial peptides can inhibit the growth and reproduction of microorganisms to a certain extent, the effect of antimicrobial peptides in food is limited by certain environmental conditions, such as light and temperature. , oxygen and other external environments, thus limiting its application in food preservation, these environmental factors have a certain impact on the activity of antimicrobial peptides

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] To prepare a prickly ash seed protein antibacterial peptide, the specific steps are as follows:

[0030] Select the Zanthoxylum bungeanum protein (content: 245.70mg / g) obtained by alkali treatment, accurately weigh 5g of Zanthoxylum bungeanum protein and dissolve it in a sufficient amount of ethanol solution, preheat it in a water bath, and adjust the enzymatic hydrolysis temperature to 32°C for liquefaction For enzymatic hydrolysis, use HCl to adjust the pH value of the solution to 2, add pepsin for enzymatic hydrolysis, and continuously add HCl and NaOH during the enzymatic hydrolysis process to maintain the pH value of the solution at 2, after enzymatic hydrolysis for 3 hours, put it in a 90°C water bath to extinguish Enzyme, cooling, pour the cooled mixture into a beaker, place in an ultrasonic cleaner with cooling water circulation, ultrasonically extract antibacterial peptides, ultrasonic power is 150W ultrasonic 5min, after ultrasonication, centrifuge at 8000r / min...

Embodiment 2

[0032] Take 4 groups (three parts for each group) of prickly ash seed protein (content: 245.70mg / g, 5g for each part) and dissolve them in a sufficient amount of solvent, preheat in a water bath, adjust the enzymolysis temperature to 32°C for liquefaction and enzymolysis, At the same time, use HCl to adjust the pH value of the solution to 2, add pepsin for enzymolysis, and continuously add HCl and NaOH to maintain the pH value of the solution during the enzymolysis process. Then centrifuge at 8000r / min for 10min, take the supernatant, and vacuum freeze-dry. (Wherein group ac also adopts ultrasonic-assisted extraction after cooling the enzyme, the mixture after cooling is about to be poured into the beaker, placed in the ultrasonic cleaner of cooling water circulation, ultrasonic extraction antimicrobial peptide, ultrasonic power is 150W ultrasonic 5min), statistics each Group productivity, specific preparation process and productivity are shown in Table 1.

[0033] Table 1

...

Embodiment 3

[0036] The Zanthoxylum bungeanum protein antibacterial peptide obtained in Example 1 is divided into 4 groups, and the concentration is 1.0wt% shellac resin sodium salt mixes evenly respectively, then inhales in the syringe, uses the high-voltage electrostatic spray capsule forming device, sprays the mixed solution to Mass concentration of 1% CaCl 2 The solution was allowed to stand and solidify for 30-45 minutes. After the microcapsule suspension was centrifuged at high speed, it was fully washed with deionized water, and then vacuum freeze-dried for 24 hours to obtain 4 groups of Zanthoxylum bungeanum antimicrobial peptide microcapsules. Select pork with a uniform appearance, divide it into small pieces of about 10g, select 10g of fresh pork and put it directly into a food-grade polyethylene (PE) plastic plate and cover it with plastic wrap as a control group, and then mix 4 groups of pepper seed antimicrobial peptide microcapsules evenly Sprayed on the surface of fresh pork...

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Abstract

The invention relates to the technical field of antibacterial peptides, and particularly discloses a preparation method of a pH-responsive zanthoxylum seed antibacterial peptide microcapsule. The method comprises the following steps of Step 1, dissolving alkali metal salt of saturated shellac resin in water, and then uniformly mixing the solution with the zanthoxylum seed protein antibacterial peptide; and Step 2, spraying the material obtained in the Step 1 into a CaCl2 solution in a high-voltage electrostatic spraying manner, then performing standing and curing for 30 to 45 minutes, and next, performing freeze-drying to obtain a finished product. The method has the advantages of simple preparation process, short extraction time, small solvent dosage and high yield of the zanthoxylum seed protein antibacterial peptide.

Description

technical field [0001] The invention relates to the technical field of antimicrobial peptides, in particular to a method for preparing pH-responsive Zanthoxylum bungeanum antimicrobial peptide microcapsules. Background technique [0002] Antimicrobial peptides are also called antibiotic peptides and antimicrobial peptides. It is a kind of polypeptide with broad-spectrum anti-bacteria, fungi, viruses, parasites, anti-tumor cells and other biological activities induced by the specific gene coding of various biological cells and induced by external conditions. Antimicrobial peptides are almost all forms of life A ubiquitous substance of the defense system, present in organisms ranging from bacteria to plants and invertebrate and vertebrate species, including mammals. They form part of the nonspecific innate immune system, the primary defense system of most organisms. Zanthoxylum bungeanum seed is the main product in the production of Zanthoxylum bungeanum peel. Zanthoxylum bu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P21/06A23L3/3526
CPCC12P21/06A23L3/3526A23V2002/00A23V2200/10A23V2250/55
Inventor 刘耀文罗典陈嵘嵘苟韬杨兴盼许端包凯文宋璟昕
Owner SICHUAN AGRI UNIV