Preparation method and application of HA material for HA soluble microneedle

A soluble, microneedle technology, applied in the directions of microneedles, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Needs, the hardness of the soluble drug-loaded microneedle tip is not up to standard, and the drying cycle of the finished product is long, so as to achieve the effects of increasing the drug-loading capacity and formability, high drug-loading capacity and drug delivery efficiency, and shortening the drying time.
CN113995951APending Publication Date: 2022-02-01浙江摩达生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
浙江摩达生物科技有限公司
Publication Date
2022-02-01

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Abstract

The invention relates to a preparation method and application of an HA material for an HA soluble microneedle. The scheme comprises the steps of uniformly mixing HA with the molecular weight of 103kDa and 2-hydroxymethyl-beta-cyclodextrin, and stirring in purified water until the HA is dissolved; freeze-drying a mixed solution obtained by dissolving, and collecting dried white powder; adding purified water into the white powder to prepare high-concentration polymer preparation gel; placing the high-concentration polymer preparation gel on a four-dimensional rotating instrument, rotating and uniformly mixing until needle point polymer gel is obtained; and taking HA with the molecular weight of 2 * 10 < 2 > kDa, adding water to prepare low-concentration polymer preparation gel, and taking the low-concentration polymer preparation gel as backing polymer gel, wherein the concentration of the low-concentration polymer is lower than that of the high-concentration polymer preparation gel. The invention also provides the microneedle patch prepared by using the method. The mechanical strength of the microneedle can be remarkably improved, the microneedle can adapt to various molds, and high drug loading capacity and drug delivery efficiency can be achieved for lipophilic and hydrophilic drugs.
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Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of HA material used for HA soluble microneedles and its application. Background technique

[0002] Microneedle is a new type of transdermal drug delivery method developed in the past 30 years, which is safe, efficient and painless. Microneedles pierce the stratum corneum, the largest barrier for transdermal drug penetration in a minimally invasive way, creating short-term reversible micropores, which allow drugs to penetrate the skin through the micropores and enter the human body to achieve therapeutic effects. The length of the microneedle and the size of the array can be designed according to the site of action and drug loading. Typically, microneedles are transdermal drug delivery devices with a length ranging within 2 mm that enable painless, minimally invasive, highly effective drug delivery and slow disease treatment over time. Si...

Claims

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