Anti-coccidial drug for livestock and poultry, fermented Chinese herbal medicine composition and preparation method and application thereof

A technology of fermenting Chinese herbal medicine and anti-coccidia, which is applied in the direction of drug combination, bacteria used in food preparation, application, etc., can solve problems such as growth inhibition of chickens and rabbits, increase of waste discharge, and drug resistance of chemically synthesized drugs. Achieve the effect of enhancing effect and increasing the content of active ingredients

Pending Publication Date: 2022-02-08
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sub-healthy or pathogenic physiological state caused by coccidiosis greatly reduces the digestion and utilization efficiency of feed, increases waste emissions, and is extremely unfavorable to environmental carbon neutrality
[0003] In animal husbandry production, commonly used drugs for the prevention and treatment of coccidiosis are chemically synthesized drugs such as sulfonamides, polyether antibiotics, and anti-coccidiosis vaccines. However, there is a problem of drug resistance in chemically synthesized drugs. It has obvious inhibitory effect on the growth and development of chickens and rabbits

Method used

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  • Anti-coccidial drug for livestock and poultry, fermented Chinese herbal medicine composition and preparation method and application thereof
  • Anti-coccidial drug for livestock and poultry, fermented Chinese herbal medicine composition and preparation method and application thereof
  • Anti-coccidial drug for livestock and poultry, fermented Chinese herbal medicine composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Preparation of compound Chinese herbal medicine

[0037] (1) Preferably, the dried ginkgo leaves, cashew nut leaves, sumac leaves, purslane and humulus are crushed to 60 mesh;

[0038] (2) Mix the Chinese herbal medicine according to the mass percentage, that is, 50% of ginkgo biloba leaves, 10% of cashew nut leaves, 10% of sumac leaves, 20% of humulus, and 10% of purslane, and mix to obtain a compound Chinese herbal medicine.

[0039] 2. Preparation of Compound Probiotic Seed Solution

[0040] (1) Each strain was cultured in shake flasks separately. Bacillus pumilus was cultured in spore-forming culture medium, which consisted of 1% glucose, 1% molasses, 1% protein powder, 0.3% potassium chloride, and 0.5% manganese sulfate, at 121°C under high pressure Sterilize for 30 minutes, pH 7.0, and incubate at 37°C for 24 hours. Lactobacillus plantarum was cultured with MRS culture medium, pH 6.5, autoclaved at 121°C for 30min, and cultured at 37°C for 24h. Saccharomyces...

Embodiment 2

[0049] 1. Preparation of compound Chinese herbal medicine

[0050] (1) Preferably, the dried ginkgo leaves, cashew nut leaves, sumac leaves, purslane and humulus are crushed to 70 mesh;

[0051] (2) Mix the Chinese herbal medicine according to the mass percentage, that is, 10% of ginkgo biloba leaves, 50% of cashew nut leaves, 10% of sumac leaves, 10% of humulus, and 20% of purslane, and mix to obtain a compound Chinese herbal medicine.

[0052] 2. Preparation of Compound Probiotic Seed Solution

[0053] (1) Each strain was cultured in shake flasks separately. Bacillus pumilus was cultured in spore-forming culture medium, which consisted of 1% glucose, 1% molasses, 1% protein powder, 0.3% potassium chloride, and 0.5% manganese sulfate, at 121°C under high pressure Sterilize for 30 minutes, pH 7.0, and incubate at 37°C for 24 hours. Lactobacillus plantarum was cultured with MRS culture medium, pH 6.5, autoclaved at 121°C for 30min, and cultured at 37°C for 24h. Saccharomyces...

Embodiment 3

[0062] 1. Preparation of compound Chinese herbal medicine

[0063] (1) Preferably, the dried ginkgo leaves, cashew leaves, sumac leaves, purslane and humulus are crushed to 80 mesh;

[0064] (2) Mix the Chinese herbal medicine according to the mass percentage, that is, 10% of ginkgo biloba leaves, 10% of cashew nut leaves, 50% of sumac leaves, 10% of humulus, and 20% of purslane, and mix to obtain a compound Chinese herbal medicine.

[0065] 2. Preparation of Compound Probiotic Seed Solution

[0066] (1) Each strain was cultured in shake flasks separately. Bacillus pumilus was cultured in spore-forming culture medium, which consisted of 1% glucose, 1% molasses, 1% protein powder, 0.3% potassium chloride, and 0.5% manganese sulfate, at 121°C under high pressure Sterilize for 30 minutes, pH 7.0, and incubate at 37°C for 24 hours. Lactobacillus plantarum was cultured with MRS culture medium, pH 6.5, autoclaved at 121°C for 30min, and cultured at 37°C for 24h. Saccharomyces cer...

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Abstract

The invention relates to an anti-coccidial fermented Chinese herbal medicine composition for livestock and poultry, a preparation method and application thereof, and belongs to the technical field of biological feed additives. The fermented Chinese herbal medicine composition is mainly prepared by fermenting compound Chinese herbal medicines with compound probiotics. The effective drug component for resisting coccidiosis is 2-pentadecenyl-6-hydroxybenzoic acid. The compound Chinese herbal medicines comprise the following components by mass: 10%-50% of ginkgo tree, 10%-50% of cashews, 10%-50% of lacquer tree, 10%-20% of purslane and 10%-20% of scandent hop. The compound probiotics comprise 10%-20% of bacillus pumilus, 20%-30% of lactobacillus plantarum and 50%-70% of saccharomyces cerevisiae. The prepared fermented Chinese herbal medicine composition can effectively prevent coccidiosis of livestock and poultry when being used as a feed additive according to an addition amount of 3%-10%.

Description

technical field [0001] The invention belongs to the technical field of biological feed additives, and in particular relates to an anticoccidial drug for livestock and poultry, a fermented Chinese herbal medicine composition and a preparation method and application thereof. Background technique [0002] Coccidiosis is an intestinal infection caused by single-celled organisms called coccidia that live inside intestinal cells. Because the coccidia live in the intestinal tract, when the eggs reach a certain number, they can cause diarrhea. Coccidiosis is especially dangerous in young poultry, pigs, and rabbits because their small intestinal defenses are underdeveloped. Coccidiosis is the main cause of growth retardation, intestinal disease and even death of susceptible animals in recent years, causing great economic losses to livestock and poultry breeding. Especially in the case of banning antibiotics, the frequent occurrence of bacterial diseases further exacerbated the occu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/105A23K10/30A23K10/12A23K10/37A23K50/50A23K50/75A23K50/30A23K50/60A61K31/192A61K36/60A61P33/02
CPCA23K20/105A23K10/30A23K10/12A23K10/37A23K50/50A23K50/75A23K50/30A23K50/60A61K31/192A61K36/16A61K36/22A61K36/185A61K36/60A61P33/02A61K2236/19A23V2400/169A61K2300/00Y02P60/87
Inventor 刘宁丁轲李一笑邓雪娟刘兆阳宋祯石函弋王建平
Owner HENAN UNIV OF SCI & TECH
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