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Photosensitive type vitreous injectable gel as well as preparation method and application thereof

A light-sensitive, gel-based technology, applied in photodynamic therapy, liquid delivery, pharmaceutical formulations, etc., can solve the problems of retinal detachment, restriction of clinical application, weak penetration of low-band light, etc., and achieve drug half-life prolongation, treatment The effect of rich targets and controllable drug release behavior

Active Publication Date: 2022-02-15
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are two limitations to this treatment method: 1. The pathological process of AMD is a comprehensive result of multi-channel interactions, and the target of local anti-angiogenesis therapy in the eye is single, and there is still a large room for optimization of the treatment effect; 2. The currently used preparations treat the symptoms but not the root cause, have poor patient compliance, and are extremely expensive, which are seriously restricting the actual clinical application
However, most of the currently known photosensitive groups are sensitive to ultraviolet light, and direct exposure of ultraviolet light to the eyeball will cause serious problems such as electro-optic ophthalmia and retinal detachment, and the low-wavelength light penetration ability is weak, so it is not suitable for direct use in the eye drug release

Method used

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  • Photosensitive type vitreous injectable gel as well as preparation method and application thereof
  • Photosensitive type vitreous injectable gel as well as preparation method and application thereof
  • Photosensitive type vitreous injectable gel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Evaluation of rhein & baicalin synergistically resisting "angiogenesis-oxidative damage" and inducing mitophagy in vitro

[0042] HUVEC cells and ARPE-19 cells in the logarithmic growth phase were seeded in 12-well plates, and incubated at 37°C, 5% CO 2 Cultured in an incubator for 24 hours to make the cells adhere to the wall. After starving the cells with basic DMEM / F12 medium for 12 hours, discard the culture medium; carry out H 2 o 2 or CoCl 2 Modeling, set blank group, model group, drug group (model+drug) and cell co-incubation, the drug group in this example is rhein+baicalin (1 / 200, w / w), after continuing to cultivate for 24h, collect The supernatants of the cells in each group were then subjected to relevant experimental procedures according to the instructions of the rat vascular endothelial growth factor (VEGF) enzyme-linked immunosorbent assay kit. At a wavelength of 450 nm on a microplate reader, measure the absorbance (A) value of each group of cells, an...

Embodiment 2

[0048] Ligustrazine & Paeoniflorin synergistically resisting "angiogenesis-oxidative damage" and inducing mitophagy in vitro

[0049] HUVEC cells and ARPE-19 cells in the logarithmic growth phase were seeded in 12-well plates, and incubated at 37°C, 5% CO 2 Cultured in an incubator for 24 hours to make the cells adhere to the wall. After starving the cells with basic DMEM / F12 medium for 12 hours, discard the culture medium; carry out H 2 o 2 or CoCl 2 Modeling, set blank group, model group, drug group (model+drug) and co-incubation with cells, the drug group in this example is ligustrazine+paeoniflorin (200 / 1, w / w), after continuing to cultivate for 24h, collect The supernatants of the cells in each group were then subjected to relevant experimental procedures according to the instructions of the rat vascular endothelial growth factor (VEGF) enzyme-linked immunosorbent assay kit. At a wavelength of 450 nm on a microplate reader, measure the absorbance (A) value of each grou...

Embodiment 3

[0055] Evaluation of Tanshinone IIA & saikosaponin synergistically resisting "angiogenesis-oxidative damage" and inducing mitophagy in vitro

[0056] HUVEC cells and ARPE-19 cells in the logarithmic growth phase were seeded in 12-well plates, and incubated at 37°C, 5% CO 2 Cultured in an incubator for 24 hours to make the cells adhere to the wall. After starving the cells with basic DMEM / F12 medium for 12 hours, discard the culture medium; carry out H 2 o 2 or CoCl 2 Modeling, set blank group, model group, drug group (model+drug) and co-incubation with cells, the drug group in this example is Tanshinone IIA+saikosaponin (1 / 2, w / w), after continuing to cultivate for 24h, collect The supernatants of the cells in each group were then subjected to relevant experimental procedures according to the instructions of the rat vascular endothelial growth factor (VEGF) enzyme-linked immunosorbent assay kit. At a wavelength of 450 nm on a microplate reader, measure the absorbance (A) va...

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Abstract

The invention relates to photosensitive type vitreous injectable gel as well as a preparation method and application thereof. The photosensitive type vitreous injectable gel is prepared from a bulk drug, a photosensitive material, upconversion nanoparticles (UCNPs) and water, wherein the bulk drug is prepared by compounding a traditional Chinese medicine active ingredient for inhibiting angiogenesis-oxidative stress and a traditional Chinese medicine active ingredient for promoting autophagy of retinal pigment epithelium (RPE); and the photosensitive material is hyaluronic acid in which a carboxyl group is covalently connected with a photosensitive group. The efficacy of treating age-related macular degeneration is enhanced through reasonable natural medicine combination; and the medicine delivery capacity of the posterior segment of the eye is improved by assembling a proper medicine delivery system, CNV formation is jointly inhibited from the two aspects of treatment medicine combination and medicine delivery efficiency, pathogenic signals are blocked in multiple links, and AMD treatment effect is improved.

Description

technical field [0001] The invention belongs to the technical field of biological materials and medicine, and in particular relates to a photosensitive vitreous injectable gel and a preparation method and application thereof. Background technique [0002] Age-related macular degeneration (AMD) is regarded by traditional medicine as "dampness retention, stasis accumulation". The pathological products such as water, dampness, and phlegm produced by it belong to phlegm fluid, which accumulate in the macula, and most of them are tangible things. , treat it according to phlegm retention; and the subretinal neovascularization caused by the accumulation of phlegm and dampness can easily lead to repeated bleeding in the macular area. "Blood Syndrome" said: "Blood blood turns into water, and it also becomes swollen." Modern medicine believes that wet AMD is an age-related macular retinal tissue degeneration disease, which is different from drusen at the base of Bruch's membrane in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K45/06A61K31/192A61K31/7048A61K31/4965A61K31/58A61K31/365A61K31/015A61K31/352A61K31/05A61K9/06A61P27/02
CPCA61K41/0057A61K45/06A61K31/192A61K31/7048A61K31/4965A61K31/58A61K31/365A61K31/015A61K31/352A61K31/05A61K9/06A61K9/0014A61P27/02A61K2300/00
Inventor 瞿鼎刘聪燕粟文婷陈彦张黄琴刘玉萍吕艳丽李晓琦
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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