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Reusable liposome suspension with sustained-release collagen and preparation method thereof

A slow-release collagen and collagen technology, applied in the directions of liposome delivery, peptide/protein components, cosmetic preparations, etc. Issues such as the release of active ingredients to achieve the best surface accessibility and application performance, improve surface accessibility and application performance, and achieve the effect of repeated use

Pending Publication Date: 2022-03-01
江苏奥普莱医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, liposomes are used as carriers to encapsulate active ingredients, because it takes a certain period of time to release active ingredients, and it is difficult to release all active ingredients with liposomes for one-time use, resulting in loss of active ingredients
In addition, liposomes are attached to solid surfaces, affected by steric hindrance, the accessibility of the liposome surface is limited, and full surface contact cannot be achieved

Method used

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  • Reusable liposome suspension with sustained-release collagen and preparation method thereof
  • Reusable liposome suspension with sustained-release collagen and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] 1. have the liposome preparation method of slow-release collagen, comprise the steps:

[0064] (1) 1.5g of chitin nanofibers, 1.5g of phosphatidylglycerol, and 0.15g of 1,4-butanediol glycidyl ether were dissolved in 75mL of water, stirred and mixed until uniformly dispersed, and reacted at 28°C until complete, the obtained The reactant is soaked in purified water according to the volume ratio of 1:10, and concentrated to the original volume with a 30,000 Dalton ultrafiltration membrane (this process is soaked three times to remove unreacted 1,4-butanediol glycidyl ether), get a suspension;

[0065] (2) Freeze-drying the suspension in (1) to remove the solvent to obtain a solid;

[0066] (3) Weigh 3.1g of the solid in (2), 1.6g of phosphatidylglycerol, 0.2g of cholesterol and 0.2g of Tween 80, dissolve in 20mL of ice ethanol, and set aside;

[0067] (4) Weigh 1 g of sodium ascorbate and 0.05 g of collagen (the molecular weight of collagen is 43 kDa), dissolve in 20 mL...

Embodiment 2

[0083] 1. have the liposome preparation method of slow-release collagen, comprise the steps:

[0084] (1) 1.5g of cellulose nanofibers, 1.5g of phosphatidylinositol, and 0.15g of 1,4-butanediol glycidyl ether were dissolved in 75mL of water, stirred and mixed until uniformly dispersed, and reacted to completion at 25°C. The reactants were soaked in purified water according to the volume ratio of 1:10, concentrated to the original volume with a 30,000 Dalton ultrafiltration membrane, and soaked three times in this process to obtain a suspension;

[0085] (2) Freeze-drying the suspension obtained in step (1) to remove the solvent to obtain a solid;

[0086] (3) Weigh 3.1 g of the solid obtained in step (2), 1.6 g of phosphatidylinositol, 0.2 g of cholesterol and 0.2 g of Tween 80, dissolve in 20 mL of ice-cold ethanol, and set aside;

[0087] (4) Weigh 1 g of sodium ascorbate and 0.05 g of collagen (the molecular weight of collagen is 55 kDa), dissolve in 20 mL of citric acid b...

Embodiment 3

[0096] 1. have the liposome preparation method of slow-release collagen, comprise the steps:

[0097] (1) 1.5g of chitin nanofibers, 1.5g of phosphatidylethanolamine, and 0.15g of 1,4-butanediol glycidyl ether were dissolved in 75mL of water, stirred and mixed until uniformly dispersed, and reacted to complete at 40°C to obtain The reactant is soaked in purified water according to the volume ratio of 1:10, and concentrated to the original volume with a 30,000 Dalton ultrafiltration membrane. This process is soaked three times to obtain a suspension;

[0098] (2) Freeze-drying the suspension obtained in step (1) to remove the solvent to obtain a solid;

[0099] (3) Weigh 3.1 g of the solid obtained in step (2), 1.6 g of phosphatidylethanolamine, 0.2 g of cholesterol and 0.2 g of Tween 80, dissolve in 20 mL of ice-cold ethanol, and set aside;

[0100] (4) Weigh 1 g of sodium ascorbate and 0.05 g of collagen (the molecular weight of collagen is 31 kDa), dissolve in 20 mL of citr...

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Abstract

The invention discloses a reusable liposome suspension with sustained-release collagen and a preparation method of the suspension. The suspension comprises liposome particles with the particle size of 70 to 1100 nm and / or 3000 to 5500 nm; the suspension is formed by an organic phase and a water phase, the concentration of phospholipid nanofibers connected by a flexible carbon chain connecting agent in the organic phase is 0.14-0.17 g / mL, and the concentration of collagen in the water phase is 1.5-3.5 mg / mL. In the preparation method provided by the invention, the lipidosome encapsulating collagen is connected to the nanofibers through the arm chain and is directionally attached to the viscose non-woven fabric, so that the lipidosome has good space flexibility, and the surface accessibility and the application performance are improved; due to the existence of the arm chain, the lipidosome floats on the surface of the non-woven fabric, so that the action effect of collagen is improved; meanwhile, the entrapment efficiency is high, repeated use can be realized, and the continuous slow release effect of the collagen is improved.

Description

technical field [0001] The invention relates to the fields of pharmaceutical preparations, skin care products and cosmetics, in particular to a reusable liposome suspension with slow-release collagen and a preparation method thereof. Background technique [0002] Liposome is an artificial membrane. The hydrophilic head of phospholipid molecule is inserted into the water, and the hydrophobic tail of liposome extends to the air. After stirring, a spherical liposome with bilayer lipid molecules is formed, with a diameter of 25-1000nm. Liposomes are structured as one or more concentric lipid bilayers. Liposome technology was applied to the field of cosmetics in the mid-1960s, but it was not until the 1970s that liposomes were applied to drug carriers and attracted widespread attention. Liposome material is similar to the composition of biological cell membrane, has good biocompatibility and degradability, so it is less irritating to the body. In addition, liposome also has the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K9/127A61K47/24A61K47/28A61K47/22A61K47/26A61K47/36A61K47/38A61P17/16A61K8/65A61K8/14A61K8/55A61K8/63A61K8/49A61K8/73A61K8/67A61K8/60A61Q19/00
CPCA61K38/39A61K9/127A61K47/24A61K47/28A61K47/22A61K47/26A61K47/36A61K47/38A61P17/16A61K8/65A61K8/14A61K8/553A61K8/63A61K8/4973A61K8/4993A61K8/731A61K8/736A61K8/676A61K8/60A61Q19/00A61K2800/84A61K2800/56
Inventor 陈美娟李鑫管荣健林琳
Owner 江苏奥普莱医疗用品有限公司
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